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Table 4.

Combined and stratified analysis of nasopharyngeal carcinoma risk by seromarkers of antibodies against EBV with cigarette smoking habit

Cigarette smokingCombination of VCA IgA/DNaseParticipant number (%)Person-yearsNasopharyngeal carcinoma
Case no.Incidence rate*Combined effect hazard ratio (95% CI)Stratum-specific effects hazard ratio (95% CI)
Quantity (pack/d)        
    <1 Both negative 5,212 (55.5) 95,442.2 13 13.6 1.0 (reference) 1.0 (reference) 
    <1 Any positive 708 (7.5) 12,005.3 16.7 1.2 (0.3-5.4) 1.3 (0.3-5.8) 
    ≥1 Both negative 2,999 (31.9) 53,844.8 14.9 1.1 (0.5-2.6) 1.0 (reference) 
    ≥1 Any positive 476 (5.1) 8,344.9 25.9 7.0 (2.9-17.0) 6.2 (2.3-16.7) 
     Test for interaction: P = 0.068   
Duration (y)        
    <30 Both negative 5,581 (60.3) 107,551.7 13 12.1 1.0 (reference) 1.0 (reference) 
    <30 Any positive 704 (7.6) 13,086.1 22.9 1.9 (0.6-6.8) 1.9 (0.6-6.8) 
    ≥30 Both negative 2,516 (27.1) 39,920.1 17.5 2.5 (0.8-7.8) 1.0 (reference) 
    ≥30 Any positive 461 (27.1) 6,941.8 86.4 12.5 (3.8-41.3) 5.0 (1.7-14.9) 
     Test for interaction: P = 0.263   
Cumulative exposure (pack-years)        
    <30 Both negative 6,315 (68.5) 118,635.2 14 11.8 1.0 (reference) 1.0 (reference) 
    <30 Any positive 840 (9.1) 14,939.4 26.8 2.3 (0.8-7.1) 2.3 (0.8-7.1) 
    ≥30 Both negative 1,748 (19.0) 28,248.3 21.2 2.4 (0.8-6.7) 1.0 (reference) 
    ≥30 Any positive 317 (3.4) 4,965.3 100.7 11.4 (3.7-35.1) 4.8 (1.5-15.9) 
     Test for interaction: P = 0.381  
 
Cigarette smokingCombination of VCA IgA/DNaseParticipant number (%)Person-yearsNasopharyngeal carcinoma
Case no.Incidence rate*Combined effect hazard ratio (95% CI)Stratum-specific effects hazard ratio (95% CI)
Quantity (pack/d)        
    <1 Both negative 5,212 (55.5) 95,442.2 13 13.6 1.0 (reference) 1.0 (reference) 
    <1 Any positive 708 (7.5) 12,005.3 16.7 1.2 (0.3-5.4) 1.3 (0.3-5.8) 
    ≥1 Both negative 2,999 (31.9) 53,844.8 14.9 1.1 (0.5-2.6) 1.0 (reference) 
    ≥1 Any positive 476 (5.1) 8,344.9 25.9 7.0 (2.9-17.0) 6.2 (2.3-16.7) 
     Test for interaction: P = 0.068   
Duration (y)        
    <30 Both negative 5,581 (60.3) 107,551.7 13 12.1 1.0 (reference) 1.0 (reference) 
    <30 Any positive 704 (7.6) 13,086.1 22.9 1.9 (0.6-6.8) 1.9 (0.6-6.8) 
    ≥30 Both negative 2,516 (27.1) 39,920.1 17.5 2.5 (0.8-7.8) 1.0 (reference) 
    ≥30 Any positive 461 (27.1) 6,941.8 86.4 12.5 (3.8-41.3) 5.0 (1.7-14.9) 
     Test for interaction: P = 0.263   
Cumulative exposure (pack-years)        
    <30 Both negative 6,315 (68.5) 118,635.2 14 11.8 1.0 (reference) 1.0 (reference) 
    <30 Any positive 840 (9.1) 14,939.4 26.8 2.3 (0.8-7.1) 2.3 (0.8-7.1) 
    ≥30 Both negative 1,748 (19.0) 28,248.3 21.2 2.4 (0.8-6.7) 1.0 (reference) 
    ≥30 Any positive 317 (3.4) 4,965.3 100.7 11.4 (3.7-35.1) 4.8 (1.5-15.9) 
     Test for interaction: P = 0.381  
 
*

Per 100,000 person-years.

Adjustment for age.

P < 0.01.

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