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Table 2.

Incidence and adjusted hazard ratio (95% CI) of developing nasopharyngeal carcinoma by seromarkers of antibodies against EBV at study entry

VariableParticipant number (%)Person-yearsNasopharyngeal carcinoma
Case no.Incidence rate*Hazard ratio (95% CI)
Anti–EBV VCA IgA (titer)      
    Seronegative (<1:10) 9,460 (98.9) 171,052.5 27 15.8 1.0 (reference) 
    1:10 87 (0.9) 1,333.9 149.9 9.5 (2.2-40.1) 
    ≥1:40 22 (0.2) 316.3 632.3 21.4 (2.8-161.7) 
    Missing 53 1,002.9 99.7  
    P value for trend     <0.0001 
Anti–EBV DNase (unit)      
    Seronegative (<2) 8,420 (88.0) 152,853.8 23 15.0 1.0 (reference) 
    2-5 1,032 (10.8) 18,000.7 22.2 1.6 (0.5-4.6) 
    ≥6 116 (1.2) 1,833.6 218.2 16.0 (5.4-47.1) 
    Missing 54 1,017.5 98.3  
    Pvalue for trend     <0.0001 
Combination of VCA IgA/DNase      
    <1:10 and <2 8,357 (87.3) 151,867.2 21 13.8 1.0 (reference) 
    1:10 and/or 2-5 1,078 (11.3) 18,748.4 21.3 1.6 (0.5-4.7) 
    ≥1:40 or ≥6 132 (1.4) 2,050.2 292.7 19.0 (7.0-51.5) 
    Missing 55 1,039.8 96.2  
    P value for trend     <0.0001 
VariableParticipant number (%)Person-yearsNasopharyngeal carcinoma
Case no.Incidence rate*Hazard ratio (95% CI)
Anti–EBV VCA IgA (titer)      
    Seronegative (<1:10) 9,460 (98.9) 171,052.5 27 15.8 1.0 (reference) 
    1:10 87 (0.9) 1,333.9 149.9 9.5 (2.2-40.1) 
    ≥1:40 22 (0.2) 316.3 632.3 21.4 (2.8-161.7) 
    Missing 53 1,002.9 99.7  
    P value for trend     <0.0001 
Anti–EBV DNase (unit)      
    Seronegative (<2) 8,420 (88.0) 152,853.8 23 15.0 1.0 (reference) 
    2-5 1,032 (10.8) 18,000.7 22.2 1.6 (0.5-4.6) 
    ≥6 116 (1.2) 1,833.6 218.2 16.0 (5.4-47.1) 
    Missing 54 1,017.5 98.3  
    Pvalue for trend     <0.0001 
Combination of VCA IgA/DNase      
    <1:10 and <2 8,357 (87.3) 151,867.2 21 13.8 1.0 (reference) 
    1:10 and/or 2-5 1,078 (11.3) 18,748.4 21.3 1.6 (0.5-4.7) 
    ≥1:40 or ≥6 132 (1.4) 2,050.2 292.7 19.0 (7.0-51.5) 
    Missing 55 1,039.8 96.2  
    P value for trend     <0.0001 

Abbreviation: IgA, immunoglobulin A; VCA, viral capsid antigen.

*

Per 100,000 person-years.

Adjustment for age and cumulative exposure to cigarette smoking (pack-years).

P < 0.01.

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