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Table 2.

Association of TYMS haplotypes with the risk of endometrial cancer

TYMSCases (%), n = 1,028Controls (%), n = 1,003OR (95% CI)*
OR (95% CI)
Dominant modelRecessive modelAdditive model
Block1      
    TTTCT 48.8 48.4 1.0 (0.8-1.3) 1.0 (0.8-1.2) 1.0 (reference) 
    CTTCT 18.3 18.8 1.0 (0.8-1.2) 1.0 (0.7-1.4) 1.0 (0.8-1.1) 
    TCCAC 15.3 15.9 0.9 (0.8-1.1) 1.2 (0.8-1.8) 0.9 (0.8-1.1) 
    TCTAC 15.0 15.0 1.0 (0.8-1.2) 1.1 (0.7-1.7) 1.0 (0.8-1.2) 
    Others 2.6 1.9   1.4 (0.9-2.1) 
Block 2§      
    TCG 54.3 52.7 1.0 (0.8-1.2) 1.1 (0.9-1.3) 1.0 (reference) 
    TTC 22.7 23.6 1.0 (0.8-1.2) 0.9 (0.8-1.3) 0.9 (0.8-1.1) 
    ATC 15.9 15.2 0.9 (0.8-1.1) 1.2 (0.8-1.7) 1.0 (0.8-1.2) 
    TTG 7.0 8.4 0.8 (0.6-1.0) 1.0 (0.4-2.3) 0.8 (0.7-1.1) 
    Others 0.1 0.1   0.6 (0.1-3.8) 
TYMSCases (%), n = 1,028Controls (%), n = 1,003OR (95% CI)*
OR (95% CI)
Dominant modelRecessive modelAdditive model
Block1      
    TTTCT 48.8 48.4 1.0 (0.8-1.3) 1.0 (0.8-1.2) 1.0 (reference) 
    CTTCT 18.3 18.8 1.0 (0.8-1.2) 1.0 (0.7-1.4) 1.0 (0.8-1.1) 
    TCCAC 15.3 15.9 0.9 (0.8-1.1) 1.2 (0.8-1.8) 0.9 (0.8-1.1) 
    TCTAC 15.0 15.0 1.0 (0.8-1.2) 1.1 (0.7-1.7) 1.0 (0.8-1.2) 
    Others 2.6 1.9   1.4 (0.9-2.1) 
Block 2§      
    TCG 54.3 52.7 1.0 (0.8-1.2) 1.1 (0.9-1.3) 1.0 (reference) 
    TTC 22.7 23.6 1.0 (0.8-1.2) 0.9 (0.8-1.3) 0.9 (0.8-1.1) 
    ATC 15.9 15.2 0.9 (0.8-1.1) 1.2 (0.8-1.7) 1.0 (0.8-1.2) 
    TTG 7.0 8.4 0.8 (0.6-1.0) 1.0 (0.4-2.3) 0.8 (0.7-1.1) 
    Others 0.1 0.1   0.6 (0.1-3.8) 
*

Calculated with HapStat software. Adjusted for age. Additional adjustment for education, menopausal status, diabetes, alcohol consumption, physical activity, and body mass index did not change the results materially.

Calculated with logistic regression model under additive genetic model.

In the order: rs3786362, rs2853532, rs3744962, rs11081251, and rs9948583.

§

In the order: rs10502289, rs2298583, and rs2298581.

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