Association of the htSNPs in the TYMS gene with endometrial cancer risk, Shanghai Endometrial Cancer Study, 1997-2003
| SNPs at TYMS gene . | Minor allele frequency in controls . | All subjects . | . | . | OR per allele . | Ptrend . | Premenopausal women . | . | . | OR per allele . | Ptrend . | Postmenopausal women . | . | . | OR per allele . | Ptrend . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | ||||||
| rs502396 | 0.280 | 1,027 | 1,003 | 444 | 386 | 583 | 617 | |||||||||||||||
| CC | 555 (54.0) | 520 (51.8) | 1.0 | 256 (57.7) | 206 (53.4) | 1.0 | 299 (51.3) | 314 (50.9) | 1.0 | |||||||||||||
| CT | 390 (38.0) | 406 (40.5) | 0.9 (0.7-1.1) | 156 (35.1) | 151 (39.1) | 0.8 (0.6-1.1) | 234 (40.1) | 255 (41.3) | 1.0 (0.8-1.2) | |||||||||||||
| TT | 82 (8.0) | 77 (7.7) | 1.0 (0.7-1.4) | 1.0 (0.8-1.1) | 0.50 | 32 (7.2) | 29 (7.5) | 1.0 (0.6-1.6) | 0.9 (0.7-1.1) | 0.39 | 50 (8.6) | 48 (7.8) | 1.1 (0.7-1.7) | 1.0 (0.8-1.2) | 0.89 | |||||||
| rs2244500 | 0.310 | 1,028 | 1,003 | 444 | 386 | 584 | 617 | |||||||||||||||
| CC | 509 (49.5) | 469 (46.8) | 1.0 | 237 (53.4) | 192 (49.7) | 1.0 | 272 (46.6) | 277 (44.9) | 1.0 | |||||||||||||
| CT | 410 (39.9) | 444 (44.3) | 0.9 (0.7-1.0) | 163 (36.7) | 162 (42.0) | 0.8 (0.6-1.1) | 247 (42.3) | 282 (45.7) | 0.9 (0.7-1.1) | |||||||||||||
| TT | 109 (10.6) | 90 (9.0) | 1.1 (0.8-1.5) | 1.0 (0.9-1.1) | 0.70 | 44 (9.9) | 32 (8.3) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.75 | 65 (11.1) | 58 (9.4) | 1.1 (0.8-1.7) | 1.0 (0.8-1.2) | 0.98 | |||||||
| rs3786362 | 0.188 | 1,031 | 1,015 | 443 | 386 | 579 | 614 | |||||||||||||||
| TT | 683 (66.8) | 659 (65.9) | 1.0 | 278 (62.8) | 245 (63.5) | 1.0 | 405 (70.0) | 414 (67.4) | 1.0 | |||||||||||||
| CT | 305 (29.8) | 306 (30.6) | 1.0 (0.8-1.2) | 151 (34.1) | 126 (32.6) | 1.0 (0.8-1.4) | 154 (26.6) | 180 (29.3) | 0.9 (0.7-1.1) | |||||||||||||
| CC | 34 (3.3) | 35 (3.5) | 0.9 (0.6-1.5) | 1.0 (0.8-1.1) | 0.65 | 14 (3.2) | 15 (3.9) | 0.9 (0.4-2.0) | 1.0 (0.8-1.3) | 0.94 | 20 (3.5) | 20 (3.3) | 1.0 (0.5-1.9) | 0.9 (0.7-1.1) | 0.44 | |||||||
| rs2853532 | 0.317 | 1,027 | 1,003 | 443 | 386 | 584 | 617 | |||||||||||||||
| TT | 499 (48.6) | 463 (46.2) | 1.0 | 231 (52.1) | 188 (48.7) | 1.0 | 268 (45.9) | 275 (44.6) | 1.0 | |||||||||||||
| CT | 417 (40.6) | 444 (44.3) | 0.9 (0.7-1.0) | 167 (37.7) | 165 (42.8) | 0.8 (0.6-1.1) | 250 (42.8) | 279 (45.2) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 111 (10.8) | 96 (9.6) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.69 | 45 (10.2) | 33 (8.6) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.79 | 66 (11.3) | 63 (10.2) | 1.1 (0.7-1.6) | 1.0 (0.8-1.2) | 0.96 | |||||||
| rs3744962 | 0.158 | 1,027 | 1,002 | 444 | 386 | 583 | 616 | |||||||||||||||
| TT | 741 (72.2) | 713 (71.2) | 1.0 | 331 (74.6) | 289 (74.9) | 1.0 | 410 (70.3) | 424 (68.8) | 1.0 | |||||||||||||
| CT | 257 (25.0) | 260 (26.0) | 1.0 (0.8-1.2) | 102 (23.0) | 89 (23.1) | 1.0 (0.7-1.4) | 155 (26.6) | 171 (27.8) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 29 (2.8) | 29 (2.9) | 1.0 (0.6-1.6) | 1.0 (0.8-1.1) | 0.65 | 11 (2.5) | 8 (2.1) | 1.2 (0.5-3.0) | 1.0 (0.8-1.3) | 0.91 | 18 (3.1) | 21 (3.4) | 0.9 (0.5-1.7) | 0.9 (0.8-1.2) | 0.57 | |||||||
| rs11081251 | 0.309 | 1,028 | 1,003 | 444 | 386 | 584 | 617 | |||||||||||||||
| CC | 512 (49.8) | 477 (47.6) | 1.0 | 239 (53.8) | 194 (50.3) | 1.0 | 273 (46.8) | 283 (45.9) | 1.0 | |||||||||||||
| AC | 409 (39.8) | 432 (43.1) | 0.9 (0.7-1.1) | 160 (36.0) | 160 (41.5) | 0.8 (0.6-1.1) | 249 (42.6) | 272 (44.1) | 1.0 (0.7-1.2) | |||||||||||||
| AA | 107 (10.4) | 94 (9.4) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.68 | 45 (10.1) | 32 (8.3) | 1.2 (0.7-2.0) | 1.0 (0.8-1.2) | 0.80 | 62 (10.6) | 62 (10.1) | 1.0 (0.7-1.5) | 1.0 (0.8-1.2) | 0.95 | |||||||
| rs9948583 | 0.320 | 1,027 | 1,001 | 443 | 386 | 584 | 615 | |||||||||||||||
| TT | 485 (47.2) | 463 (46.3) | 1.0 | 230 (51.9) | 191 (49.5) | 1.0 | 255 (43.7) | 272 (44.2) | 1.0 | |||||||||||||
| CT | 427 (41.6) | 436 (43.6) | 0.9 (0.8-1.1) | 166 (37.5) | 161 (41.7) | 0.9 (0.6-1.1) | 261 (44.7) | 275 (44.7) | 1.0 (0.8-1.3) | |||||||||||||
| CC | 115 (11.2) | 102 (10.2) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.99 | 47 (10.6) | 34 (8.8) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.97 | 68 (11.6) | 68 (11.1) | 1.1 (0.7-1.6) | 1.0 (0.9-1.2) | 0.76 | |||||||
| rs3819102 | 0.237 | 1,027 | 1,001 | 444 | 386 | 583 | 615 | |||||||||||||||
| TT | 574 (55.9) | 576 (57.5) | 1.0 | 257 (57.9) | 213 (55.2) | 1.0 | 317 (54.4) | 363 (59.0) | 1.0 | |||||||||||||
| CT | 379 (36.9) | 376 (37.6) | 1.0 (0.8-1.2) | 158 (35.6) | 154 (39.9) | 0.8 (0.6-1.1) | 221 (37.9) | 222 (36.1) | 1.1 (0.9-1.5) | |||||||||||||
| CC | 74 (7.2) | 49 (4.9) | 1.5 (1.0-2.2) | 1.1 (1.0-1.3) | 0.14 | 29 (6.5) | 19 (4.9) | 1.3 (0.7-2.3) | 1.0 (0.8-1.2) | 0.72 | 45 (7.7) | 30 (4.9) | 1.7 (1.1-2.8) | 1.2 (1.0-1.5) | 0.03 | |||||||
| rs10502289 | 0.154 | 1,025 | 1,001 | 443 | 386 | 582 | 615 | |||||||||||||||
| TT | 726 (70.8) | 721 (72.0) | 1.0 | 307 (69.3) | 278 (72.0) | 1.0 | 419 (72.0) | 443 (72.0) | 1.0 | |||||||||||||
| AT | 271 (26.4) | 255 (25.5) | 1.1 (0.9-1.3) | 121 (27.3) | 99 (25.7) | 1.1 (0.8-1.5) | 150 (25.8) | 156 (25.4) | 1.0 (0.8-1.3) | |||||||||||||
| AA | 28 (2.7) | 25 (2.5) | 1.1 (0.6-1.9) | 1.1 (0.9-1.2) | 0.53 | 15 (3.4) | 9 (2.3) | 1.6 (0.6-3.5) | 1.1 (0.9-1.5) | 0.39 | 13 (2.2) | 16 (2.6) | 0.9 (0.4-1.8) | 1.0 (0.8-1.2) | 0.90 | |||||||
| rs2298583 | 0.471 | 1,027 | 1,002 | 443 | 386 | 584 | 616 | |||||||||||||||
| CC | 306 (29.8) | 282 (28.1) | 1.0 | 115 (26.0) | 99 (25.7) | 1.0 | 191 (32.7) | 183 (29.7) | 1.0 | |||||||||||||
| CT | 504 (49.1) | 496 (49.5) | 0.9 (0.8-1.1) | 226 (51.0) | 193 (50.0) | 1.0 (0.7-1.3) | 278 (47.6) | 303 (49.2) | 0.9 (0.7-1.1) | |||||||||||||
| TT | 217 (21.1) | 224 (22.4) | 0.9 (0.7-1.1) | 0.9 (0.8-1.1) | 0.36 | 102 (23.0) | 94 (24.4) | 0.9 (0.6-1.4) | 1.0 (0.8-1.2) | 0.66 | 115 (19.7) | 130 (21.1) | 0.8 (0.6-1.2) | 0.9 (0.8-1.1) | 0.27 | |||||||
| rs2298581 | 0.389 | 1,024 | 1,003 | 441 | 386 | 583 | 617 | |||||||||||||||
| GG | 386 (37.7) | 375 (37.4) | 1.0 | 149 (33.8) | 139 (36.0) | 1.0 | 237 (40.7) | 236 (38.3) | 1.0 | |||||||||||||
| CG | 485 (47.4) | 478 (47.7) | 1.0 (0.8-1.2) | 218 (49.4) | 186 (48.2) | 1.1 (0.8-1.4) | 267 (45.8) | 292 (47.3) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 153 (14.9) | 150 (15.0) | 1.0 (0.8-1.3) | 1.0 (0.9-1.1) | 0.92 | 74 (16.8) | 61 (15.8) | 1.1 (0.8-1.7) | 1.1 (0.9-1.3) | 0.54 | 79 (13.6) | 89 (14.4) | 0.9 (0.6-1.3) | 0.9 (0.8-1.1) | 0.39 | |||||||
| SNPs at TYMS gene . | Minor allele frequency in controls . | All subjects . | . | . | OR per allele . | Ptrend . | Premenopausal women . | . | . | OR per allele . | Ptrend . | Postmenopausal women . | . | . | OR per allele . | Ptrend . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | Cases (%) . | Controls (%) . | OR (95% CI) . | . | . | ||||||
| rs502396 | 0.280 | 1,027 | 1,003 | 444 | 386 | 583 | 617 | |||||||||||||||
| CC | 555 (54.0) | 520 (51.8) | 1.0 | 256 (57.7) | 206 (53.4) | 1.0 | 299 (51.3) | 314 (50.9) | 1.0 | |||||||||||||
| CT | 390 (38.0) | 406 (40.5) | 0.9 (0.7-1.1) | 156 (35.1) | 151 (39.1) | 0.8 (0.6-1.1) | 234 (40.1) | 255 (41.3) | 1.0 (0.8-1.2) | |||||||||||||
| TT | 82 (8.0) | 77 (7.7) | 1.0 (0.7-1.4) | 1.0 (0.8-1.1) | 0.50 | 32 (7.2) | 29 (7.5) | 1.0 (0.6-1.6) | 0.9 (0.7-1.1) | 0.39 | 50 (8.6) | 48 (7.8) | 1.1 (0.7-1.7) | 1.0 (0.8-1.2) | 0.89 | |||||||
| rs2244500 | 0.310 | 1,028 | 1,003 | 444 | 386 | 584 | 617 | |||||||||||||||
| CC | 509 (49.5) | 469 (46.8) | 1.0 | 237 (53.4) | 192 (49.7) | 1.0 | 272 (46.6) | 277 (44.9) | 1.0 | |||||||||||||
| CT | 410 (39.9) | 444 (44.3) | 0.9 (0.7-1.0) | 163 (36.7) | 162 (42.0) | 0.8 (0.6-1.1) | 247 (42.3) | 282 (45.7) | 0.9 (0.7-1.1) | |||||||||||||
| TT | 109 (10.6) | 90 (9.0) | 1.1 (0.8-1.5) | 1.0 (0.9-1.1) | 0.70 | 44 (9.9) | 32 (8.3) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.75 | 65 (11.1) | 58 (9.4) | 1.1 (0.8-1.7) | 1.0 (0.8-1.2) | 0.98 | |||||||
| rs3786362 | 0.188 | 1,031 | 1,015 | 443 | 386 | 579 | 614 | |||||||||||||||
| TT | 683 (66.8) | 659 (65.9) | 1.0 | 278 (62.8) | 245 (63.5) | 1.0 | 405 (70.0) | 414 (67.4) | 1.0 | |||||||||||||
| CT | 305 (29.8) | 306 (30.6) | 1.0 (0.8-1.2) | 151 (34.1) | 126 (32.6) | 1.0 (0.8-1.4) | 154 (26.6) | 180 (29.3) | 0.9 (0.7-1.1) | |||||||||||||
| CC | 34 (3.3) | 35 (3.5) | 0.9 (0.6-1.5) | 1.0 (0.8-1.1) | 0.65 | 14 (3.2) | 15 (3.9) | 0.9 (0.4-2.0) | 1.0 (0.8-1.3) | 0.94 | 20 (3.5) | 20 (3.3) | 1.0 (0.5-1.9) | 0.9 (0.7-1.1) | 0.44 | |||||||
| rs2853532 | 0.317 | 1,027 | 1,003 | 443 | 386 | 584 | 617 | |||||||||||||||
| TT | 499 (48.6) | 463 (46.2) | 1.0 | 231 (52.1) | 188 (48.7) | 1.0 | 268 (45.9) | 275 (44.6) | 1.0 | |||||||||||||
| CT | 417 (40.6) | 444 (44.3) | 0.9 (0.7-1.0) | 167 (37.7) | 165 (42.8) | 0.8 (0.6-1.1) | 250 (42.8) | 279 (45.2) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 111 (10.8) | 96 (9.6) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.69 | 45 (10.2) | 33 (8.6) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.79 | 66 (11.3) | 63 (10.2) | 1.1 (0.7-1.6) | 1.0 (0.8-1.2) | 0.96 | |||||||
| rs3744962 | 0.158 | 1,027 | 1,002 | 444 | 386 | 583 | 616 | |||||||||||||||
| TT | 741 (72.2) | 713 (71.2) | 1.0 | 331 (74.6) | 289 (74.9) | 1.0 | 410 (70.3) | 424 (68.8) | 1.0 | |||||||||||||
| CT | 257 (25.0) | 260 (26.0) | 1.0 (0.8-1.2) | 102 (23.0) | 89 (23.1) | 1.0 (0.7-1.4) | 155 (26.6) | 171 (27.8) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 29 (2.8) | 29 (2.9) | 1.0 (0.6-1.6) | 1.0 (0.8-1.1) | 0.65 | 11 (2.5) | 8 (2.1) | 1.2 (0.5-3.0) | 1.0 (0.8-1.3) | 0.91 | 18 (3.1) | 21 (3.4) | 0.9 (0.5-1.7) | 0.9 (0.8-1.2) | 0.57 | |||||||
| rs11081251 | 0.309 | 1,028 | 1,003 | 444 | 386 | 584 | 617 | |||||||||||||||
| CC | 512 (49.8) | 477 (47.6) | 1.0 | 239 (53.8) | 194 (50.3) | 1.0 | 273 (46.8) | 283 (45.9) | 1.0 | |||||||||||||
| AC | 409 (39.8) | 432 (43.1) | 0.9 (0.7-1.1) | 160 (36.0) | 160 (41.5) | 0.8 (0.6-1.1) | 249 (42.6) | 272 (44.1) | 1.0 (0.7-1.2) | |||||||||||||
| AA | 107 (10.4) | 94 (9.4) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.68 | 45 (10.1) | 32 (8.3) | 1.2 (0.7-2.0) | 1.0 (0.8-1.2) | 0.80 | 62 (10.6) | 62 (10.1) | 1.0 (0.7-1.5) | 1.0 (0.8-1.2) | 0.95 | |||||||
| rs9948583 | 0.320 | 1,027 | 1,001 | 443 | 386 | 584 | 615 | |||||||||||||||
| TT | 485 (47.2) | 463 (46.3) | 1.0 | 230 (51.9) | 191 (49.5) | 1.0 | 255 (43.7) | 272 (44.2) | 1.0 | |||||||||||||
| CT | 427 (41.6) | 436 (43.6) | 0.9 (0.8-1.1) | 166 (37.5) | 161 (41.7) | 0.9 (0.6-1.1) | 261 (44.7) | 275 (44.7) | 1.0 (0.8-1.3) | |||||||||||||
| CC | 115 (11.2) | 102 (10.2) | 1.1 (0.8-1.4) | 1.0 (0.9-1.1) | 0.99 | 47 (10.6) | 34 (8.8) | 1.2 (0.7-1.9) | 1.0 (0.8-1.2) | 0.97 | 68 (11.6) | 68 (11.1) | 1.1 (0.7-1.6) | 1.0 (0.9-1.2) | 0.76 | |||||||
| rs3819102 | 0.237 | 1,027 | 1,001 | 444 | 386 | 583 | 615 | |||||||||||||||
| TT | 574 (55.9) | 576 (57.5) | 1.0 | 257 (57.9) | 213 (55.2) | 1.0 | 317 (54.4) | 363 (59.0) | 1.0 | |||||||||||||
| CT | 379 (36.9) | 376 (37.6) | 1.0 (0.8-1.2) | 158 (35.6) | 154 (39.9) | 0.8 (0.6-1.1) | 221 (37.9) | 222 (36.1) | 1.1 (0.9-1.5) | |||||||||||||
| CC | 74 (7.2) | 49 (4.9) | 1.5 (1.0-2.2) | 1.1 (1.0-1.3) | 0.14 | 29 (6.5) | 19 (4.9) | 1.3 (0.7-2.3) | 1.0 (0.8-1.2) | 0.72 | 45 (7.7) | 30 (4.9) | 1.7 (1.1-2.8) | 1.2 (1.0-1.5) | 0.03 | |||||||
| rs10502289 | 0.154 | 1,025 | 1,001 | 443 | 386 | 582 | 615 | |||||||||||||||
| TT | 726 (70.8) | 721 (72.0) | 1.0 | 307 (69.3) | 278 (72.0) | 1.0 | 419 (72.0) | 443 (72.0) | 1.0 | |||||||||||||
| AT | 271 (26.4) | 255 (25.5) | 1.1 (0.9-1.3) | 121 (27.3) | 99 (25.7) | 1.1 (0.8-1.5) | 150 (25.8) | 156 (25.4) | 1.0 (0.8-1.3) | |||||||||||||
| AA | 28 (2.7) | 25 (2.5) | 1.1 (0.6-1.9) | 1.1 (0.9-1.2) | 0.53 | 15 (3.4) | 9 (2.3) | 1.6 (0.6-3.5) | 1.1 (0.9-1.5) | 0.39 | 13 (2.2) | 16 (2.6) | 0.9 (0.4-1.8) | 1.0 (0.8-1.2) | 0.90 | |||||||
| rs2298583 | 0.471 | 1,027 | 1,002 | 443 | 386 | 584 | 616 | |||||||||||||||
| CC | 306 (29.8) | 282 (28.1) | 1.0 | 115 (26.0) | 99 (25.7) | 1.0 | 191 (32.7) | 183 (29.7) | 1.0 | |||||||||||||
| CT | 504 (49.1) | 496 (49.5) | 0.9 (0.8-1.1) | 226 (51.0) | 193 (50.0) | 1.0 (0.7-1.3) | 278 (47.6) | 303 (49.2) | 0.9 (0.7-1.1) | |||||||||||||
| TT | 217 (21.1) | 224 (22.4) | 0.9 (0.7-1.1) | 0.9 (0.8-1.1) | 0.36 | 102 (23.0) | 94 (24.4) | 0.9 (0.6-1.4) | 1.0 (0.8-1.2) | 0.66 | 115 (19.7) | 130 (21.1) | 0.8 (0.6-1.2) | 0.9 (0.8-1.1) | 0.27 | |||||||
| rs2298581 | 0.389 | 1,024 | 1,003 | 441 | 386 | 583 | 617 | |||||||||||||||
| GG | 386 (37.7) | 375 (37.4) | 1.0 | 149 (33.8) | 139 (36.0) | 1.0 | 237 (40.7) | 236 (38.3) | 1.0 | |||||||||||||
| CG | 485 (47.4) | 478 (47.7) | 1.0 (0.8-1.2) | 218 (49.4) | 186 (48.2) | 1.1 (0.8-1.4) | 267 (45.8) | 292 (47.3) | 0.9 (0.7-1.2) | |||||||||||||
| CC | 153 (14.9) | 150 (15.0) | 1.0 (0.8-1.3) | 1.0 (0.9-1.1) | 0.92 | 74 (16.8) | 61 (15.8) | 1.1 (0.8-1.7) | 1.1 (0.9-1.3) | 0.54 | 79 (13.6) | 89 (14.4) | 0.9 (0.6-1.3) | 0.9 (0.8-1.1) | 0.39 | |||||||
NOTE: OR: adjusted for age. Additional adjustment for education, menopausal status, diabetes, alcohol consumption, physical activity, and body mass index did not change the results materially.
Pinteraction test was 0.24 between menopausal status and rs3819102 genotypes.