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Table 4.

Urinary isothiocyanates in relation to risk of colorectal cancer by GST genotypes

Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)P for interaction
GSTM1      
    GSTM1 non-null, undetectable ITC 19 (23) 31 (19) 1.00 1.00  
    GSTM1 non-null, detectable ITC 63 (77) 135 (81) 0.59 (0.25-1.39) 0.49 (0.19-1.25)  
    GSTM1 null, undetectable ITC 23 (25) 26 (18) 1.00 1.00  
    GSTM1 null, detectable ITC 68 (75) 121 (82) 0.56 (0.21-1.46) 0.53 (0.15-1.93) 0.42 
GSTT1      
    GSTT1 non-null, undetectable ITC 32 (25) 39 (19) 1.00 1.00  
    GSTT1 non-null, detectable ITC 95 (75) 162 (81) 0.63 (0.33-1.20) 0.56 (0.28-1.13)  
    GSTT1 null, undetectable ITC 10 (22) 18 (16) 1.00 1.00  
    GSTT1 null, detectable ITC 36 (78) 94 (84) 1.07 (0.32-3.57) 0.86 (0.17-4.43) 0.36 
GSTP1      
    GSTP1 AA, undetectable ITC 21 (21) 24 (15) 1.00 1.00  
    GSTP1 AA, detectable ITC 78 (79) 138 (85) 0.53 (0.22-1.30) 0.58 (0.22-1.48)  
    GSTP1 AG/GG, undetectable ITC 21 (28) z33 (22) 1.00 1.00  
    GSTP1 AG/GG, detectable ITC 53 (72) 118 (78) 0.57 (0.25-1.31) 0.47 (0.19-1.17) 0.09 
Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)P for interaction
GSTM1      
    GSTM1 non-null, undetectable ITC 19 (23) 31 (19) 1.00 1.00  
    GSTM1 non-null, detectable ITC 63 (77) 135 (81) 0.59 (0.25-1.39) 0.49 (0.19-1.25)  
    GSTM1 null, undetectable ITC 23 (25) 26 (18) 1.00 1.00  
    GSTM1 null, detectable ITC 68 (75) 121 (82) 0.56 (0.21-1.46) 0.53 (0.15-1.93) 0.42 
GSTT1      
    GSTT1 non-null, undetectable ITC 32 (25) 39 (19) 1.00 1.00  
    GSTT1 non-null, detectable ITC 95 (75) 162 (81) 0.63 (0.33-1.20) 0.56 (0.28-1.13)  
    GSTT1 null, undetectable ITC 10 (22) 18 (16) 1.00 1.00  
    GSTT1 null, detectable ITC 36 (78) 94 (84) 1.07 (0.32-3.57) 0.86 (0.17-4.43) 0.36 
GSTP1      
    GSTP1 AA, undetectable ITC 21 (21) 24 (15) 1.00 1.00  
    GSTP1 AA, detectable ITC 78 (79) 138 (85) 0.53 (0.22-1.30) 0.58 (0.22-1.48)  
    GSTP1 AG/GG, undetectable ITC 21 (28) z33 (22) 1.00 1.00  
    GSTP1 AG/GG, detectable ITC 53 (72) 118 (78) 0.57 (0.25-1.31) 0.47 (0.19-1.17) 0.09 
*

Based on conditional logistic regression, using matched sets as strata.

Further adjusted for age at blood draw, hours of fasting before blood draw, processed meat (density, g/kcal/d), ethanol (g/d), obesity, and history of colorectal cancer screening.

Values based on adjusted models, with urinary isothiocyanates, adjusted for creatinine, as a continuous variable.

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