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Table 3.

GSTM1, GSTT1, and GSTP1 genotypes in relation to risk of colorectal cancer

Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)
GSTM1     
    Non-null 82 (47) 166 (53) 1.00 (Reference) 1.00 (Reference) 
    Null 91 (53) 147 (47) 1.30 (0.89-1.89) 1.31 (0.88-1.94) 
    By number of copies     
        2 13 (8) 36 (12) 1.00 (Reference) 1.00 (Reference) 
        1 69 (40) 130 (42) 1.49 (0.74-2.97) 1.38 (0.67-2.84) 
        0 91 (53) 147 (47) 1.77 (0.91-3.47) 1.68 (0.84-3.35) 
        P for trend   0.09 0.12 
GSTT1     
    Non-null 127 (73) 201 (64) 1.00 (Reference) 1.00 (Reference) 
    Null 46 (27) 112 (36) 0.60 (0.38-0.94) 0.62 (0.39-1.00) 
    By number of copies     
        2 41 (24) 77 (25) 1.00 (Reference) 1.00 (Reference) 
        1 86 (50) 124 (40) 1.29 (0.79-2.12) 1.28 (0.76-2.14) 
        0 46 (27) 112 (36) 0.72 (0.40-1.28) 0.75 (0.41-1.37) 
        P for trend   0.20 0.27 
GSTP1 rs1695     
    AA 99 (57) 162 (52) 1.00 (Reference) 1.00 (Reference) 
    AG or GG 74 (43) 151 (48) 0.78 (0.51-1.19) 0.76 (0.49-1.18) 
    AA 113 (56) 188 (51) 1.00 (Reference) 1.00 (Reference) 
    AG 59 (34) 110 (35) 0.85 (0.55-1.30) 0.81 (0.52-1.28) 
    GG 15 (9) 41 (13) 0.54 (0.27-1.10) 0.57 (0.28-1.19) 
    P for trend   0.10 0.13 
Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)
GSTM1     
    Non-null 82 (47) 166 (53) 1.00 (Reference) 1.00 (Reference) 
    Null 91 (53) 147 (47) 1.30 (0.89-1.89) 1.31 (0.88-1.94) 
    By number of copies     
        2 13 (8) 36 (12) 1.00 (Reference) 1.00 (Reference) 
        1 69 (40) 130 (42) 1.49 (0.74-2.97) 1.38 (0.67-2.84) 
        0 91 (53) 147 (47) 1.77 (0.91-3.47) 1.68 (0.84-3.35) 
        P for trend   0.09 0.12 
GSTT1     
    Non-null 127 (73) 201 (64) 1.00 (Reference) 1.00 (Reference) 
    Null 46 (27) 112 (36) 0.60 (0.38-0.94) 0.62 (0.39-1.00) 
    By number of copies     
        2 41 (24) 77 (25) 1.00 (Reference) 1.00 (Reference) 
        1 86 (50) 124 (40) 1.29 (0.79-2.12) 1.28 (0.76-2.14) 
        0 46 (27) 112 (36) 0.72 (0.40-1.28) 0.75 (0.41-1.37) 
        P for trend   0.20 0.27 
GSTP1 rs1695     
    AA 99 (57) 162 (52) 1.00 (Reference) 1.00 (Reference) 
    AG or GG 74 (43) 151 (48) 0.78 (0.51-1.19) 0.76 (0.49-1.18) 
    AA 113 (56) 188 (51) 1.00 (Reference) 1.00 (Reference) 
    AG 59 (34) 110 (35) 0.85 (0.55-1.30) 0.81 (0.52-1.28) 
    GG 15 (9) 41 (13) 0.54 (0.27-1.10) 0.57 (0.28-1.19) 
    P for trend   0.10 0.13 
*

Based on conditional logistic regression, using matched sets as strata.

Further adjusted for age at blood draw, hours of fasting before blood draw, processed meat (density, g/kcal/d), ethanol (g/d), obesity, and history of colorectal cancer screening.

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