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Table 2.

Urinary isothiocyanate levels in relation to risk of colorectal cancer

Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)
Urinary ITC     
    Undetectable 42 (24) 57 (18) 1.00 (Reference) 1.00 (Reference) 
    Detectable 131 (76) 256 (82) 0.68 (0.42-1.09) 0.59 (0.36-0.98) 
By amount detected (μmol/mg creatinine)     
    0.0 41 (24) 57 (18) 1.00 (Reference) 1.00 (Reference) 
    >0.0-1.40 65 (38) 123 (39) 0.69 (0.42-1.15) 0.58 (0.34-1.00) 
    >1.40 66 (38) 133 (42) 0.66 (0.38-1.15) 0.61 (0.34-1.09) 
    P for trend   0.36 0.42 
Cases n (%)Controls n (%)Crude OR*(95% CI)Adjusted OR (95% CI)
Urinary ITC     
    Undetectable 42 (24) 57 (18) 1.00 (Reference) 1.00 (Reference) 
    Detectable 131 (76) 256 (82) 0.68 (0.42-1.09) 0.59 (0.36-0.98) 
By amount detected (μmol/mg creatinine)     
    0.0 41 (24) 57 (18) 1.00 (Reference) 1.00 (Reference) 
    >0.0-1.40 65 (38) 123 (39) 0.69 (0.42-1.15) 0.58 (0.34-1.00) 
    >1.40 66 (38) 133 (42) 0.66 (0.38-1.15) 0.61 (0.34-1.09) 
    P for trend   0.36 0.42 

Abbreviation: ITC, isothiocyanate.

*

Based on conditional logistic regression, using matched sets as strata.

Further adjusted for age at blood draw, hours of fasting before blood draw, processed meat (density, g/kcal/d), ethanol (g/d), obesity, and history of colorectal cancer screening.

Group trend based on medians of isothiocyanate groupings (μmol/g creatinine) = 0.00, 0.58, and 4.08, respectively.

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