Adjusted ORs (95% CIs) for the association between AR haplotypes and endometrial cancer risk in a population based case-control study in Poland
| Haplotype* . | . | . | . | . | . | Percentage of cases (n = 497) . | Percentage of controls (n = 1,024) . | OR† (95% CI) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs962458 . | rs6152 . | rs1204038 . | rs2361634 . | rs1337080 . | rs1337082 . | . | . | . | |||||
| Block‡ | |||||||||||||
| A | G | G | A | A | A | 71 | 68 | 1 (reference) | |||||
| A | G | G | A | A | G | 5 | 5 | 1.07 (0.77-1.49) | |||||
| A | G | G | G | A | A | 6 | 7 | 0.92 (0.67-1.25) | |||||
| A | A | A | A | A | G | 11 | 8 | 1.51 (1.17-1.96) | |||||
| G | A | A | A | G | G | 7 | 7 | 1.00 (0.74-1.37) | |||||
| Rare haplotypes§ | 1.16 (0.62-2.17) | ||||||||||||
| Global P∥ | 0.055 | ||||||||||||
| Haplotype* . | . | . | . | . | . | Percentage of cases (n = 497) . | Percentage of controls (n = 1,024) . | OR† (95% CI) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs962458 . | rs6152 . | rs1204038 . | rs2361634 . | rs1337080 . | rs1337082 . | . | . | . | |||||
| Block‡ | |||||||||||||
| A | G | G | A | A | A | 71 | 68 | 1 (reference) | |||||
| A | G | G | A | A | G | 5 | 5 | 1.07 (0.77-1.49) | |||||
| A | G | G | G | A | A | 6 | 7 | 0.92 (0.67-1.25) | |||||
| A | A | A | A | A | G | 11 | 8 | 1.51 (1.17-1.96) | |||||
| G | A | A | A | G | G | 7 | 7 | 1.00 (0.74-1.37) | |||||
| Rare haplotypes§ | 1.16 (0.62-2.17) | ||||||||||||
| Global P∥ | 0.055 | ||||||||||||
Loci of AR htSNPs are written 5′ to 3′.
Unconditional logistic regression, adjusted for frequency matching variables age (±5 y) and site (Lodz, Warsaw).
One haplotype block structure based on Polish endometrial cancer study population. All htSNPs were included. The nucleotide in bold indicates the minor allele and the normal script indicates the major allele.
Haplotypes with frequencies < 0.01 categorized into a group of rare haplotypes.
Global test for entire set of haplotypes matched on age (±5 y) and site (Lodz, Warsaw).