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Table 5.

Multivariate RR (95% CI) for the association between physical activity and breast cancer incidence among postmenopausal women according to joint effect of physical activity and BMI, joint effect of physical activity and MHT use, and joint effect of physical activity and family history of breast cancer

No. casesPhysical activity (times per week)
Inactive<11-23-4≥5
BMI (kg/m2      
    ≥25.0 3,787 1.0 (Reference) 0.98 (0.89-1.08) 0.98 (0.90-1.08) 0.92 (0.84-1.01) 0.86 (0.77-0.96) 
    <25.0 2,822 0.84 (0.75-0.94) 0.85 (0.75-0.96) 0.76 (0.68-0.84) 0.84 (0.77-0.92) 0.80 (0.72-0.88) 
MHT use       
    Ever use 4,073 1.0 (Reference) 1.03 (0.93-1.15) 1.00 (0.90-1.10) 1.01 (0.92-1.10) 0.97 (0.88-1.08) 
    Never use 2,528 0.79 (0.72-0.88) 0.76 (0.67-0.85) 0.70 (0.63-0.78) 0.68 (0.61-0.76) 0.60 (0.53-0.68) 
Family history       
    Family history 1,193 1.0 (Reference) 0.99 (0.83-1.19) 0.92 (0.78-1.08) 0.75 (0.64-0.89) 0.75 (0.62-0.91) 
    No family history 5,124 0.57 (0.50-0.65) 0.57 (0.50-0.65) 0.54 (0.48-0.62) 0.56 (0.49-0.64) 0.51 (0.44-0.58) 
No. casesPhysical activity (times per week)
Inactive<11-23-4≥5
BMI (kg/m2      
    ≥25.0 3,787 1.0 (Reference) 0.98 (0.89-1.08) 0.98 (0.90-1.08) 0.92 (0.84-1.01) 0.86 (0.77-0.96) 
    <25.0 2,822 0.84 (0.75-0.94) 0.85 (0.75-0.96) 0.76 (0.68-0.84) 0.84 (0.77-0.92) 0.80 (0.72-0.88) 
MHT use       
    Ever use 4,073 1.0 (Reference) 1.03 (0.93-1.15) 1.00 (0.90-1.10) 1.01 (0.92-1.10) 0.97 (0.88-1.08) 
    Never use 2,528 0.79 (0.72-0.88) 0.76 (0.67-0.85) 0.70 (0.63-0.78) 0.68 (0.61-0.76) 0.60 (0.53-0.68) 
Family history       
    Family history 1,193 1.0 (Reference) 0.99 (0.83-1.19) 0.92 (0.78-1.08) 0.75 (0.64-0.89) 0.75 (0.62-0.91) 
    No family history 5,124 0.57 (0.50-0.65) 0.57 (0.50-0.65) 0.54 (0.48-0.62) 0.56 (0.49-0.64) 0.51 (0.44-0.58) 

NOTE: Multivariate models used age as the underlying time metric and were adjusted for race/ethnicity (White, Black, Hispanic, Asian/Pacific Islander/American Indian), education level (<12 years or high school equivalent, 12 years or high school equivalent, post-high school vocational or technical training, some college, college graduate, postgraduate), smoking status (nonsmoker, former, current), family history of breast cancer (no, yes), menopausal hormone use (never, current, past), age at first birth (nulliparous, <20, 20-24, 25-29, ≥30 years), age at menarche (<13, 13-14, ≥15 years), age at menopause (<40, 40-44, 45-49, 50-54, ≥55 years), parity (number of children: 0, 1-2, ≥3), and alcohol intake (g/d; quintiles adjusted for total energy intake).

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