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Table 2.

RR (95% CI) for the association between physical activity and postmenopausal breast cancer incidence among 182,862 postmenopausal women

Physical activity (times per week)Person-yearsNo. casesAge-adjusted RR (95% CI)Multivariate RR* (95% CI)Multivariate RR (95% CI)
Inactive 285,349 1,485 1.0 (Reference) 1.0 (Reference) 1.0 (Reference) 
<1 184,682 981 1.04 (0.96-1.13) 0.99 (0.91-1.07) 1.00 (0.92-1.08) 
1-2 271,497 1,391 0.99 (0.92-1.07) 0.94 (0.87-1.01) 0.96 (0.89-1.03) 
3-4 325,701 1,711 1.01 (0.94-1.08) 0.93 (0.87-1.00) 0.97 (0.90-1.04) 
≥5 211,557 1,041 0.94 (0.87-1.02) 0.87 (0.81-0.95) 0.92 (0.85-1.00) 
Ptrend   0.13 <0.001 0.04 
Physical activity (times per week)Person-yearsNo. casesAge-adjusted RR (95% CI)Multivariate RR* (95% CI)Multivariate RR (95% CI)
Inactive 285,349 1,485 1.0 (Reference) 1.0 (Reference) 1.0 (Reference) 
<1 184,682 981 1.04 (0.96-1.13) 0.99 (0.91-1.07) 1.00 (0.92-1.08) 
1-2 271,497 1,391 0.99 (0.92-1.07) 0.94 (0.87-1.01) 0.96 (0.89-1.03) 
3-4 325,701 1,711 1.01 (0.94-1.08) 0.93 (0.87-1.00) 0.97 (0.90-1.04) 
≥5 211,557 1,041 0.94 (0.87-1.02) 0.87 (0.81-0.95) 0.92 (0.85-1.00) 
Ptrend   0.13 <0.001 0.04 
*

Multivariate models used age as the underlying time metric and were adjusted for race/ethnicity (White, Black, Hispanic, Asian/Pacific Islander/American Indian), education level (<12 years or high school equivalent, 12 years or high school equivalent, post-high school vocational or technical training, some college, college graduate, postgraduate), smoking status (nonsmoker, former, current), family history of breast cancer (no, yes), menopausal hormone use (never, current, past), age at first birth (nulliparous, <20, 20-24, 25-29, ≥30 years), age at menarche (<13, 13-14, ≥15 years), age at menopause (<40, 40-44, 45-49, 50-54, ≥55 years), parity (number of children: 0, 1-2, ≥3), and alcohol intake (g/d; quintiles adjusted for total energy intake).

Additionally adjusted for BMI (<25.0, 25.0-29.9, 30.0-34.9, ≥35.0 kg/m2).

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