Skip to Main Content
Table 3.

Multivariate relative risk of bladder cancer to according BMI in participants defined by selected variables

VariableNo. casesBMI (kg/m2)
PtrendPinteraction
18.5-24.925.0-29.930.0-34.9≥35.0
Gender        
    Men 1,470 1.0 1.21 (1.07-1.37) 1.21 (1.03-1.43) 1.25 (0.96-1.63) 0.079 0.061 
    Women 249 1.0 0.84 (0.62-1.15) 1.38 (0.96-1.96) 1.37 (0.87-2.18) 0.146  
Age at baseline (y)        
    <65 798 1.0 1.14 (0.96-1.36) 1.27 (1.02-1.57) 1.26 (0.92-1.72) 0.026 0.919 
    ≥65 921 1.0 1.16 (0.99-1.35) 1.17 (0.95-1.45) 1.32 (0.94-1.84) 0.376  
Race/ethnicity        
    White 1,629 1.0 1.16 (1.03-1.31) 1.22 (1.05-1.43) 1.29 (1.02-1.64) 0.024 0.849 
    Non-White 90 1.0 0.99 (0.61-1.64) 1.19 (0.63-2.24) 0.93 (0.24-2.50) 0.942  
Education        
    Some college or less 1,097 1.0 1.13 (0.98-1.31) 1.25 (1.04-1.49) 1.19 (0.89-1.57) 0.137 0.662 
    College graduate or postgraduate 622 1.0 1.19 (0.99-1.43) 1.15 (0.89-1.49) 1.47 (0.99-1.19) 0.104  
Smoking status        
    Current smoker 389 1.0 1.13 (0.89-1.41) 1.17 (0.88-1.61) 1.07 (0.62-1.87) 0.502 0.862 
    Former smoker 1,047 1.0 1.20 (1.03-1.40) 1.24 (1.02-1.51) 1.32 (0.99-1.76) 0.179  
    Never smoker 283 1.0 1.05 (0.79-1.38) 1.29 (0.89-1.86) 1.42 (0.82-2.46) 0.028  
Physical activity*        
    Inactive 914 1.0 1.09 (0.92-1.28) 1.06 (0.86-1.29) 1.33 (1.01-1.74) 0.352 0.087 
    Active 805 1.0 1.22 (1.03-1.43) 1.44 (1.16-1.79) 0.98 (0.61-1.57) 0.020  
Fruit and vegetable intakes        
    Low 998 1.0 1.07 (0.92-1.25) 1.17 (0.96-1.42) 1.41 (1.07-1.87) 0.102 0.107 
    High 721 1.0 1.26 (1.06-1.50) 1.29 (1.02-1.64) 1.05 (0.70-1.55) 0.171  
Red meat intake        
    Low 750 1.0 1.21 (1.02-1.43) 1.34 (1.06-1.69) 1.19 (0.79-1.79) 0.023 0.606 
    High 969 1.0 1.11 (0.95-1.30) 1.15 (0.94-1.39) 1.30 (0.98-1.72) 0.289  
Nonalcoholic beverage intake§        
    Low 751 1.0 1.11 (0.93-1.31) 1.08 (0.85-1.36) 0.95 (0.65-1.39) 0.474 0.179 
    High 968 1.0 1.21 (1.03-1.41) 1.36 (1.12-1.66) 1.56 (1.17-2.07) 0.017  
Alcohol use        
    No 360 1.0 1.15 (0.89-1.49) 1.21 (0.88-1.66) 1.32 (0.85-2.40) 0.175 0.989 
    Yes 1,359 1.0 1.16 (1.02-1.32) 1.23 (1.04-1.46) 1.27 (0.97-1.66) 0.071  
NSAID use        
    No 480 1.0 1.23 (0.99-1.52) 1.22 (0.91-1.64) 1.20 (0.74-1.96) 0.183 0.458 
    Yes 406 1.0 1.02 (0.80-1.29) 1.24 (0.92-1.66) 0.80 (0.47-1.37) 0.989  
VariableNo. casesBMI (kg/m2)
PtrendPinteraction
18.5-24.925.0-29.930.0-34.9≥35.0
Gender        
    Men 1,470 1.0 1.21 (1.07-1.37) 1.21 (1.03-1.43) 1.25 (0.96-1.63) 0.079 0.061 
    Women 249 1.0 0.84 (0.62-1.15) 1.38 (0.96-1.96) 1.37 (0.87-2.18) 0.146  
Age at baseline (y)        
    <65 798 1.0 1.14 (0.96-1.36) 1.27 (1.02-1.57) 1.26 (0.92-1.72) 0.026 0.919 
    ≥65 921 1.0 1.16 (0.99-1.35) 1.17 (0.95-1.45) 1.32 (0.94-1.84) 0.376  
Race/ethnicity        
    White 1,629 1.0 1.16 (1.03-1.31) 1.22 (1.05-1.43) 1.29 (1.02-1.64) 0.024 0.849 
    Non-White 90 1.0 0.99 (0.61-1.64) 1.19 (0.63-2.24) 0.93 (0.24-2.50) 0.942  
Education        
    Some college or less 1,097 1.0 1.13 (0.98-1.31) 1.25 (1.04-1.49) 1.19 (0.89-1.57) 0.137 0.662 
    College graduate or postgraduate 622 1.0 1.19 (0.99-1.43) 1.15 (0.89-1.49) 1.47 (0.99-1.19) 0.104  
Smoking status        
    Current smoker 389 1.0 1.13 (0.89-1.41) 1.17 (0.88-1.61) 1.07 (0.62-1.87) 0.502 0.862 
    Former smoker 1,047 1.0 1.20 (1.03-1.40) 1.24 (1.02-1.51) 1.32 (0.99-1.76) 0.179  
    Never smoker 283 1.0 1.05 (0.79-1.38) 1.29 (0.89-1.86) 1.42 (0.82-2.46) 0.028  
Physical activity*        
    Inactive 914 1.0 1.09 (0.92-1.28) 1.06 (0.86-1.29) 1.33 (1.01-1.74) 0.352 0.087 
    Active 805 1.0 1.22 (1.03-1.43) 1.44 (1.16-1.79) 0.98 (0.61-1.57) 0.020  
Fruit and vegetable intakes        
    Low 998 1.0 1.07 (0.92-1.25) 1.17 (0.96-1.42) 1.41 (1.07-1.87) 0.102 0.107 
    High 721 1.0 1.26 (1.06-1.50) 1.29 (1.02-1.64) 1.05 (0.70-1.55) 0.171  
Red meat intake        
    Low 750 1.0 1.21 (1.02-1.43) 1.34 (1.06-1.69) 1.19 (0.79-1.79) 0.023 0.606 
    High 969 1.0 1.11 (0.95-1.30) 1.15 (0.94-1.39) 1.30 (0.98-1.72) 0.289  
Nonalcoholic beverage intake§        
    Low 751 1.0 1.11 (0.93-1.31) 1.08 (0.85-1.36) 0.95 (0.65-1.39) 0.474 0.179 
    High 968 1.0 1.21 (1.03-1.41) 1.36 (1.12-1.66) 1.56 (1.17-2.07) 0.017  
Alcohol use        
    No 360 1.0 1.15 (0.89-1.49) 1.21 (0.88-1.66) 1.32 (0.85-2.40) 0.175 0.989 
    Yes 1,359 1.0 1.16 (1.02-1.32) 1.23 (1.04-1.46) 1.27 (0.97-1.66) 0.071  
NSAID use        
    No 480 1.0 1.23 (0.99-1.52) 1.22 (0.91-1.64) 1.20 (0.74-1.96) 0.183 0.458 
    Yes 406 1.0 1.02 (0.80-1.29) 1.24 (0.92-1.66) 0.80 (0.47-1.37) 0.989  

NOTE: The multivariate models were adjusted for covariates listed in Table 2 footnote. In each case, the stratification variable was excluded from the model. Within each stratum, the category of subjects with a BMI of 18.5 to 24.9 served as the reference group.

*

Inactive was defined as engaging in <20 min of continuous vigorous exercise three times a week. Active was defined as engaging in at least 20 min of continuous vigorous exercise three times a week.

The strata of low and high fruit and vegetable intakes were defined based on the cut point representing the median value of 3.2 servings/1,000 kcal/d.

The strata of low and high red meat intakes were defined based on the cut point representing the median value of 31.4 g/1,000 kcal/d.

§

The strata of low and high nonalcoholic beverage intakes were defined based on the cut point representing the median value of 1,782 mL/d.

The analysis that was stratified by NSAID use was conducted using data from a subcohort of study participants for whom we had collected information regarding NSAID use.

Close Modal

or Create an Account

Close Modal
Close Modal