Rate of prostate cancer diagnosis, HR, and number of men requiring follow-up for 5 years to diagnose one prostate cancer by age group and baseline PSA category
| PSA category . | No. cancers* . | Person-years risk* . | Age category (y) . | . | . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | All men . | <50 . | 50-59 . | 60-69 . | ≥70 . | |||||||
| . | . | . | Rate of diagnosis of prostate cancer per 1,000 person-years (95% CI) . | . | . | . | . | |||||||
| 0.0-0.99 | 51 | 128,450.75 | 0.40 (0.30-0.52) | 0.03 (0.00-0.2) | 0.23 (0.12-0.44) | 0.44 (0.26-0.75) | 1.24 (0.85-1.80) | |||||||
| 1.0-1.99 | 110 | 104,261.63 | 1.06 (0.88-1.27) | 0.13 (0.03-0.52) | 0.73 (0.48-1.11) | 1.18 (0.86-1.62) | 1.81 (1.36-2.41) | |||||||
| 2.0-2.99 | 115 | 56,342.03 | 2.04 (1.70-2.45) | 0.68 (0.22-2.12) | 1.51 (0.96-2.37) | 2.36 (1.77-3.14) | 2.36 (1.77-3.15) | |||||||
| 3.0-3.99 | 126 | 29,477.74 | 4.27 (3.59-5.09) | 3.90 (1.46-10.39) | 3.57 (2.25-5.67) | 5.39 (4.16-6.99) | 3.66 (2.75-4.87) | |||||||
| 4.0-9.99 | 569 | 61,580.21 | 9.24 (8.51-10.03) | 4.41 (1.98-9.81) | 9.73 (7.67-12.34) | 11.14 (9.79-12.68) | 8.13 (7.21-9.17) | |||||||
| ≥10 | 1787 | 30,403.89 | 58.78 (56.11-61.56) | 9.52 (4.54-19.96) | 45.90 (38.30-55.02) | 53.85 (48.92-59.26) | 64.32 (60.84-67.99) | |||||||
| Total | 2758 | 410,516.25 | 6.72 (6.47-6.97) | 0.39 (0.26-0.59) | 2.63 (2.32-2.97) | 6.51 (6.08-6.98) | 12.70 (12.11-13.32) | |||||||
| HR (95% CI)† | ||||||||||||||
| 0.0-0.99 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |||||||||
| 1.0-1.99 | 2.68 (1.91-3.70) | 4.65 (0.42-51.24)‡ | 3.19 (1.47-6.94) | 2.68 (1.45-4.93) | 1.49 (0.93-2.40)‡ | |||||||||
| 2.0-2.99 | 5.09 (3.66-7.07) | 24.35 (2.53-234.06) | 6.60 (2.98-14.58) | 5.36 (2.95-9.73) | 1.94 (1.20-3.11) | |||||||||
| 3.0-3.99 | 10.56 (7.63-14.62) | 138.96 (15.53-1,243.32) | 15.58 (7.00-34.67) | 12.22 (6.81-21.93) | 2.99 (1.86-4.80) | |||||||||
| 4.0-9.99 | 22.61 (16.98-30.12) | 157.46 (18.96-1,307.92) | 42.16 (21.03-84.49) | 25.16 (14.67-43.15) | 6.65 (4.47-9.88) | |||||||||
| ≥10 | 133.98 (98.60-172.10) | 335.12 (41.23-2,723.92) | 192.95 (97.94-380.12) | 116.95 (68.66-199.20) | 48.42 (33.07-70.90) | |||||||||
| No. men requiring follow-up for 5 y to diagnose one prostate cancer | ||||||||||||||
| 0.0-0.99 | 500 | 6,667 | 870 | 455 | 161 | |||||||||
| 1.0-1.99 | 189 | 1,538 | 274 | 169 | 110 | |||||||||
| 2.0-2.99 | 98 | 294 | 132 | 85 | 85 | |||||||||
| 3.0-3.99 | 47 | 51 | 56 | 37 | 55 | |||||||||
| 4.0-9.99 | 22 | 45 | 21 | 18 | 35 | |||||||||
| ≥10 | 3 | 21 | 4 | 4 | 3 | |||||||||
| Total | 30 | 513 | 76 | 31 | 16 | |||||||||
| No. cancers | 2,758 | 23 | 253 | 805 | 1,677 | |||||||||
| Person-years risk | 410,516.25 | 58,485.54 | 96,337.43 | 123,650.17 | 132,043.11 | |||||||||
| PSA category . | No. cancers* . | Person-years risk* . | Age category (y) . | . | . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | All men . | <50 . | 50-59 . | 60-69 . | ≥70 . | |||||||
| . | . | . | Rate of diagnosis of prostate cancer per 1,000 person-years (95% CI) . | . | . | . | . | |||||||
| 0.0-0.99 | 51 | 128,450.75 | 0.40 (0.30-0.52) | 0.03 (0.00-0.2) | 0.23 (0.12-0.44) | 0.44 (0.26-0.75) | 1.24 (0.85-1.80) | |||||||
| 1.0-1.99 | 110 | 104,261.63 | 1.06 (0.88-1.27) | 0.13 (0.03-0.52) | 0.73 (0.48-1.11) | 1.18 (0.86-1.62) | 1.81 (1.36-2.41) | |||||||
| 2.0-2.99 | 115 | 56,342.03 | 2.04 (1.70-2.45) | 0.68 (0.22-2.12) | 1.51 (0.96-2.37) | 2.36 (1.77-3.14) | 2.36 (1.77-3.15) | |||||||
| 3.0-3.99 | 126 | 29,477.74 | 4.27 (3.59-5.09) | 3.90 (1.46-10.39) | 3.57 (2.25-5.67) | 5.39 (4.16-6.99) | 3.66 (2.75-4.87) | |||||||
| 4.0-9.99 | 569 | 61,580.21 | 9.24 (8.51-10.03) | 4.41 (1.98-9.81) | 9.73 (7.67-12.34) | 11.14 (9.79-12.68) | 8.13 (7.21-9.17) | |||||||
| ≥10 | 1787 | 30,403.89 | 58.78 (56.11-61.56) | 9.52 (4.54-19.96) | 45.90 (38.30-55.02) | 53.85 (48.92-59.26) | 64.32 (60.84-67.99) | |||||||
| Total | 2758 | 410,516.25 | 6.72 (6.47-6.97) | 0.39 (0.26-0.59) | 2.63 (2.32-2.97) | 6.51 (6.08-6.98) | 12.70 (12.11-13.32) | |||||||
| HR (95% CI)† | ||||||||||||||
| 0.0-0.99 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |||||||||
| 1.0-1.99 | 2.68 (1.91-3.70) | 4.65 (0.42-51.24)‡ | 3.19 (1.47-6.94) | 2.68 (1.45-4.93) | 1.49 (0.93-2.40)‡ | |||||||||
| 2.0-2.99 | 5.09 (3.66-7.07) | 24.35 (2.53-234.06) | 6.60 (2.98-14.58) | 5.36 (2.95-9.73) | 1.94 (1.20-3.11) | |||||||||
| 3.0-3.99 | 10.56 (7.63-14.62) | 138.96 (15.53-1,243.32) | 15.58 (7.00-34.67) | 12.22 (6.81-21.93) | 2.99 (1.86-4.80) | |||||||||
| 4.0-9.99 | 22.61 (16.98-30.12) | 157.46 (18.96-1,307.92) | 42.16 (21.03-84.49) | 25.16 (14.67-43.15) | 6.65 (4.47-9.88) | |||||||||
| ≥10 | 133.98 (98.60-172.10) | 335.12 (41.23-2,723.92) | 192.95 (97.94-380.12) | 116.95 (68.66-199.20) | 48.42 (33.07-70.90) | |||||||||
| No. men requiring follow-up for 5 y to diagnose one prostate cancer | ||||||||||||||
| 0.0-0.99 | 500 | 6,667 | 870 | 455 | 161 | |||||||||
| 1.0-1.99 | 189 | 1,538 | 274 | 169 | 110 | |||||||||
| 2.0-2.99 | 98 | 294 | 132 | 85 | 85 | |||||||||
| 3.0-3.99 | 47 | 51 | 56 | 37 | 55 | |||||||||
| 4.0-9.99 | 22 | 45 | 21 | 18 | 35 | |||||||||
| ≥10 | 3 | 21 | 4 | 4 | 3 | |||||||||
| Total | 30 | 513 | 76 | 31 | 16 | |||||||||
| No. cancers | 2,758 | 23 | 253 | 805 | 1,677 | |||||||||
| Person-years risk | 410,516.25 | 58,485.54 | 96,337.43 | 123,650.17 | 132,043.11 | |||||||||