QFIA of β-catenin in the acini/epithelium of archived biopsies from PC cases and controls
| Controls (acini) . | . | . | PC cases . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient code . | Average corrected MPI* . | SD . | Patient code . | Noncancerous acini . | . | Cancerous acini/epithelium . | . | ||||||
| . | . | . | . | Average corrected MPI (P value)† . | SD . | Average corrected MPI (prostatic intraepithelial neoplasia)‡ . | SD . | ||||||
| NPC1 | 783 | 183 | PC1§ | 689 (P = 0.02) | 120 | 655 | 85 | ||||||
| NPC2 | 733 | 125 | PC2§ | 654 (P < 0.01) | 146 | 579 | 131 | ||||||
| NPC3 | 786 | 123 | PC3§ | 639 (P < 0.01) | 159 | 505 | 122 | ||||||
| NPC4 | 627 | 111 | PC4§ | 569 (P = 0.009) | 59 | 440 | 90 | ||||||
| NPC5 | 826 | 121 | PC5§ | 616 (P < 0.01) | 116 | 412 | 79 | ||||||
| NPC6 | 746 | 158 | PC6§ | 731 (P = 0.01) | 130 | 807 (665) | 142 | ||||||
| NPC7 | 669 | 121 | PC7§ | 603 (P < 0.01) | 76 | 436 | 94 | ||||||
| NPC8 | 748 | 111 | PC8§ | 584 (P < 0.01) | 98 | 577 (611) | 119 | ||||||
| NPC9 | 670 | 123 | PC9§ | 603 (P < 0.01) | 109 | 588 | 119 | ||||||
| NPC10 | 768 | 110 | PC10§ | 510 (P < 0.01) | 112 | 414 | 86 | ||||||
| NPC11 | 742 | 121 | PC11§ | 596 (P < 0.01) | 96 | 188 | 38 | ||||||
| NPC12 | 720 | 131 | PC12§ | 586 (P < 0.01) | 103 | 558 | 120 | ||||||
| NPC13 | 648 | 89 | PC13§ | 551 (P < 0.01) | 103 | 401 (550) | 111 | ||||||
| NPC14 | 595 | 97 | PC14§ | 537 (P < 0.01) | 84 | 410 | 68 | ||||||
| NPC15 | 668 | 110 | PC15§ | 544 (P < 0.01) | 120 | 563 | 134 | ||||||
| NPC16 | 828 | 138 | PC16§ | 595 (P < 0.01) | 109 | 487 | 68 | ||||||
| NPC17 | 635 | 104 | PC17§ | 537 (P = 0.006) | 111 | 521 | 94 | ||||||
| NPC18 | 700 | 113 | PC18§ | 610 (P < 0.01) | 122 | 429 | 77 | ||||||
| NPC19 | 723 | 140 | PC19§ | 586 (P < 0.01) | 104 | 445 | 65 | ||||||
| NPC20 | 563 | 100 | PC20§ | 449 (P < 0.01) | 104 | 381 | 113 | ||||||
| NPC21 | 716 | 152 | PC21§ | 472 (P < 0.01) | 94 | 233 | 86 | ||||||
| NPC22 | 507 | 84 | PC22§ | 450 (P < 0.01) | 89 | 185 | 59 | ||||||
| NPC23 | 567 | 127 | PC23§ | 352 (P < 0.01) | 76 | 335 | 65 | ||||||
| NPC24 | 859 | 155 | PC24§ | 438 (P < 0.01) | 114 | 221 | 49 | ||||||
| NPC25 | 777 | 127 | PC25§ | 491 (P < 0.01) | 89 | 354 (427) | 90 | ||||||
| NPC26 | 549 | 81 | PC26§ | 360 (P = 0.001) | 62 | 338 | 65 | ||||||
| NPC27 | 581 | 115 | PC27§ | 427 (P < 0.01) | 84 | 356 | 60 | ||||||
| NPC28 | 625 | 121 | PC28§ | 489 (P < 0.01) | 123 | 456 | 87 | ||||||
| NPC29 | 565 | 142 | PC29§ | 459 (P < 0.01) | 88 | 369 | 71 | ||||||
| NPC30 | 643 | 100 | PC30§ | 475 (P < 0.01) | 107 | 445 | 112 | ||||||
| NPC31 | 624 | 153 | PC31§ | 474 (P < 0.01) | 99 | 406 | 92 | ||||||
| NPC32 | 579 | 111 | PC32∥ | 772 (P < 0.01) | 168 | 453 | 132 | ||||||
| NPC33 | 685 | 130 | PC33∥ | 725 (P < 0.01) | 177 | 504 | 88 | ||||||
| NPC34 | 577 | 124 | PC34∥ | 690 (P = 0.002) | 167 | 518 | 107 | ||||||
| NPC35 | 654 | 115 | PC35∥ | 786 (P < 0.01) | 152 | 558 | 110 | ||||||
| NPC36 | 681 | 113 | PC36∥ | 749 (P < 0.01) | 120 | 649 | 130 | ||||||
| NPC37 | 531 | 74 | PC37∥ | 535 (P = 0.01) | 92 | 408 (645) | 87 | ||||||
| NPC38 | 754 | 214 | PC38 | 709 (P = 0.43) | 106 | 439 | 62 | ||||||
| NPC39 | 629 | 86 | PC39 | 622 (P = 0.12) | 108 | 615 | 76 | ||||||
| NPC40 | 820 | 121 | PC40 | 890 (P = 0.99) | 139 | 784 | 127 | ||||||
| NPC41 | 675 | 118 | PC41 | 714 (P = 0.29) | 163 | 411 (487) | 77 | ||||||
| NPC42 | 511 | 58 | PC42 | 552 (P = 0.06) | 114 | 411 | 103 | ||||||
| Average | 674 | 92 | 581 | 118 | 458 | 136 | |||||||
| Controls (acini) . | . | . | PC cases . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient code . | Average corrected MPI* . | SD . | Patient code . | Noncancerous acini . | . | Cancerous acini/epithelium . | . | ||||||
| . | . | . | . | Average corrected MPI (P value)† . | SD . | Average corrected MPI (prostatic intraepithelial neoplasia)‡ . | SD . | ||||||
| NPC1 | 783 | 183 | PC1§ | 689 (P = 0.02) | 120 | 655 | 85 | ||||||
| NPC2 | 733 | 125 | PC2§ | 654 (P < 0.01) | 146 | 579 | 131 | ||||||
| NPC3 | 786 | 123 | PC3§ | 639 (P < 0.01) | 159 | 505 | 122 | ||||||
| NPC4 | 627 | 111 | PC4§ | 569 (P = 0.009) | 59 | 440 | 90 | ||||||
| NPC5 | 826 | 121 | PC5§ | 616 (P < 0.01) | 116 | 412 | 79 | ||||||
| NPC6 | 746 | 158 | PC6§ | 731 (P = 0.01) | 130 | 807 (665) | 142 | ||||||
| NPC7 | 669 | 121 | PC7§ | 603 (P < 0.01) | 76 | 436 | 94 | ||||||
| NPC8 | 748 | 111 | PC8§ | 584 (P < 0.01) | 98 | 577 (611) | 119 | ||||||
| NPC9 | 670 | 123 | PC9§ | 603 (P < 0.01) | 109 | 588 | 119 | ||||||
| NPC10 | 768 | 110 | PC10§ | 510 (P < 0.01) | 112 | 414 | 86 | ||||||
| NPC11 | 742 | 121 | PC11§ | 596 (P < 0.01) | 96 | 188 | 38 | ||||||
| NPC12 | 720 | 131 | PC12§ | 586 (P < 0.01) | 103 | 558 | 120 | ||||||
| NPC13 | 648 | 89 | PC13§ | 551 (P < 0.01) | 103 | 401 (550) | 111 | ||||||
| NPC14 | 595 | 97 | PC14§ | 537 (P < 0.01) | 84 | 410 | 68 | ||||||
| NPC15 | 668 | 110 | PC15§ | 544 (P < 0.01) | 120 | 563 | 134 | ||||||
| NPC16 | 828 | 138 | PC16§ | 595 (P < 0.01) | 109 | 487 | 68 | ||||||
| NPC17 | 635 | 104 | PC17§ | 537 (P = 0.006) | 111 | 521 | 94 | ||||||
| NPC18 | 700 | 113 | PC18§ | 610 (P < 0.01) | 122 | 429 | 77 | ||||||
| NPC19 | 723 | 140 | PC19§ | 586 (P < 0.01) | 104 | 445 | 65 | ||||||
| NPC20 | 563 | 100 | PC20§ | 449 (P < 0.01) | 104 | 381 | 113 | ||||||
| NPC21 | 716 | 152 | PC21§ | 472 (P < 0.01) | 94 | 233 | 86 | ||||||
| NPC22 | 507 | 84 | PC22§ | 450 (P < 0.01) | 89 | 185 | 59 | ||||||
| NPC23 | 567 | 127 | PC23§ | 352 (P < 0.01) | 76 | 335 | 65 | ||||||
| NPC24 | 859 | 155 | PC24§ | 438 (P < 0.01) | 114 | 221 | 49 | ||||||
| NPC25 | 777 | 127 | PC25§ | 491 (P < 0.01) | 89 | 354 (427) | 90 | ||||||
| NPC26 | 549 | 81 | PC26§ | 360 (P = 0.001) | 62 | 338 | 65 | ||||||
| NPC27 | 581 | 115 | PC27§ | 427 (P < 0.01) | 84 | 356 | 60 | ||||||
| NPC28 | 625 | 121 | PC28§ | 489 (P < 0.01) | 123 | 456 | 87 | ||||||
| NPC29 | 565 | 142 | PC29§ | 459 (P < 0.01) | 88 | 369 | 71 | ||||||
| NPC30 | 643 | 100 | PC30§ | 475 (P < 0.01) | 107 | 445 | 112 | ||||||
| NPC31 | 624 | 153 | PC31§ | 474 (P < 0.01) | 99 | 406 | 92 | ||||||
| NPC32 | 579 | 111 | PC32∥ | 772 (P < 0.01) | 168 | 453 | 132 | ||||||
| NPC33 | 685 | 130 | PC33∥ | 725 (P < 0.01) | 177 | 504 | 88 | ||||||
| NPC34 | 577 | 124 | PC34∥ | 690 (P = 0.002) | 167 | 518 | 107 | ||||||
| NPC35 | 654 | 115 | PC35∥ | 786 (P < 0.01) | 152 | 558 | 110 | ||||||
| NPC36 | 681 | 113 | PC36∥ | 749 (P < 0.01) | 120 | 649 | 130 | ||||||
| NPC37 | 531 | 74 | PC37∥ | 535 (P = 0.01) | 92 | 408 (645) | 87 | ||||||
| NPC38 | 754 | 214 | PC38 | 709 (P = 0.43) | 106 | 439 | 62 | ||||||
| NPC39 | 629 | 86 | PC39 | 622 (P = 0.12) | 108 | 615 | 76 | ||||||
| NPC40 | 820 | 121 | PC40 | 890 (P = 0.99) | 139 | 784 | 127 | ||||||
| NPC41 | 675 | 118 | PC41 | 714 (P = 0.29) | 163 | 411 (487) | 77 | ||||||
| NPC42 | 511 | 58 | PC42 | 552 (P = 0.06) | 114 | 411 | 103 | ||||||
| Average | 674 | 92 | 581 | 118 | 458 | 136 | |||||||
Average of the background corrected MPI of β-catenin labeling in individual acini.
NAA in cancerous glands compared with NA of the matched controls.
Average corrected MPI of β-catenin labeling in prostate intraepithelial neoplastic lesions.
β-Catenin is significantly down-regulated in NAA compared with NA.
β-Catenin is significantly up-regulated in NAA compared with NA.