Skip to Main Content
Table 3.

RR (95% CI) for prostate cancer by control quintiles of whole blood fatty acid levels

Quintile of fatty acid level
Ptrend*
1 (reference)2345
n-6 Fatty acids       
Linoleic (18:2n-6)       
    Concentration, % 21.4 23.7 25.3 26.7 28.8  
    Cases/controls 121/96 94/96 99/96 85/94 77/94  
    Adjusted RR 1.00 0.73 (0.49-1.11) 0.77 (0.52-1.16) 0.68 (0.45-1.03) 0.62 (0.41-0.95) 0.03 
γ-Linolenic (18:3n-6)       
    Concentration, % 0.15 0.22 0.26 0.32 0.40  
    Cases/controls 88/94 79/97 94/95 92/95 123/95  
    Adjusted RR 1.00 0.87 (0.57-1.33) 1.05 (0.69-1.60) 1.04 (0.68-1.57) 1.41 (0.94-2.12) 0.05 
Dihomo-γ-linolenic (20:3n-6)       
    Concentration, % 1.07 1.24 1.36 1.49 1.75  
    Cases/controls 83/94 89/94 81/95 93/96 130/97  
    Adjusted RR 1.00 1.06 (0.70-1.60) 0.97 (0.63-1.49) 1.11 (0.74-1.66) 1.54 (1.03-2.30) 0.02 
Arachidonic (20:4n-6)       
    Concentration, % 7.9 9.3 10.1 10.9 12.3  
    Cases/controls 90/96 110/96 93/95 86/94 97/95  
    Adjusted RR 1.00 1.22 (0.82-1.81) 1.05 (0.70-1.57) 0.98 (0.66-1.46) 1.09 (0.72-1.64) 0.98 
       
n-3 Fatty acids       
α-Linolenic (18:3n-3)       
    Concentration, % 0.24 0.30 0.35 0.41 0.54  
    Cases/controls 83/97 97/96 98/94 90/95 108/94  
    Adjusted RR 1.00 1.17 (0.78-1.75) 1.19 (0.81-1.76) 1.10 (0.73-1.65) 1.31 (0.89-1.95) 0.24 
Eicosapentaenoic (20:5n-3)       
    Concentration, % 1.28 1.58 1.79 1.99 2.36  
    Cases/controls 109/95 106/96 96/95 96/97 69/93  
    Adjusted RR 1.00 0.93 (0.62-1.38) 0.83 (0.54-1.25) 0.77 (0.49-1.21) 0.57 (0.36-0.92) 0.02 
Docosapentaenoic (22:5n-3)       
    Concentration, % 0.77 0.88 0.97 1.06 1.19  
    Cases/controls 114/96 106/94 103/96 79/94 74/96  
    Adjusted RR 1.00 0.93 (0.63-1.37) 0.88 (0.59-1.30) 0.68 (0.45-1.02) 0.60 (0.38-0.93) 0.01 
Docosahexaenoic (22:6n-3)       
    Concentration, % 1.42 1.89 2.19 2.65 3.37  
    Cases/controls 100/95 82/94 119/95 116/97 59/95  
    Adjusted RR 1.00 0.85 (0.57-1.28) 1.22 (0.81-1.84) 1.14 (0.76-1.71) 0.60 (0.39-0.93) 0.07 
Long-chain n-3       
    Concentration, % 3.66 4.44 4.94 5.57 6.70  
    Cases/controls 107/95 105/95 112/94 84/98 68/94  
    Adjusted RR 1.00 0.97 (0.66-1.44) 1.02 (0.67-1.54) 0.74 (0.49-1.13) 0.59 (0.38-0.93) 0.01 
       
n-6/n-3 ratios       
Linoleic/α-linolenic       
    Ratio 45.8 62.0 70.8 82.8 103.7  
    Cases/controls 111/96 107/93 99/94 71/97 88/96  
    Adjusted RR 1.00 1.01 (0.67-1.52) 0.91 (0.62-1.33) 0.61 (0.40-0.94) 0.80 (0.54-1.19) 0.08 
Arachidonic/eicosapentaenoic       
    Ratio 4.18 5.08 5.66 6.42 7.64  
    Cases/controls 80/94 86/97 99/95 116/96 95/94  
    Adjusted RR 1.00 1.06 (0.69-1.63) 1.26 (0.83-1.91) 1.52 (0.98-2.37) 1.30 (0.80-2.11) 0.14 
Quintile of fatty acid level
Ptrend*
1 (reference)2345
n-6 Fatty acids       
Linoleic (18:2n-6)       
    Concentration, % 21.4 23.7 25.3 26.7 28.8  
    Cases/controls 121/96 94/96 99/96 85/94 77/94  
    Adjusted RR 1.00 0.73 (0.49-1.11) 0.77 (0.52-1.16) 0.68 (0.45-1.03) 0.62 (0.41-0.95) 0.03 
γ-Linolenic (18:3n-6)       
    Concentration, % 0.15 0.22 0.26 0.32 0.40  
    Cases/controls 88/94 79/97 94/95 92/95 123/95  
    Adjusted RR 1.00 0.87 (0.57-1.33) 1.05 (0.69-1.60) 1.04 (0.68-1.57) 1.41 (0.94-2.12) 0.05 
Dihomo-γ-linolenic (20:3n-6)       
    Concentration, % 1.07 1.24 1.36 1.49 1.75  
    Cases/controls 83/94 89/94 81/95 93/96 130/97  
    Adjusted RR 1.00 1.06 (0.70-1.60) 0.97 (0.63-1.49) 1.11 (0.74-1.66) 1.54 (1.03-2.30) 0.02 
Arachidonic (20:4n-6)       
    Concentration, % 7.9 9.3 10.1 10.9 12.3  
    Cases/controls 90/96 110/96 93/95 86/94 97/95  
    Adjusted RR 1.00 1.22 (0.82-1.81) 1.05 (0.70-1.57) 0.98 (0.66-1.46) 1.09 (0.72-1.64) 0.98 
       
n-3 Fatty acids       
α-Linolenic (18:3n-3)       
    Concentration, % 0.24 0.30 0.35 0.41 0.54  
    Cases/controls 83/97 97/96 98/94 90/95 108/94  
    Adjusted RR 1.00 1.17 (0.78-1.75) 1.19 (0.81-1.76) 1.10 (0.73-1.65) 1.31 (0.89-1.95) 0.24 
Eicosapentaenoic (20:5n-3)       
    Concentration, % 1.28 1.58 1.79 1.99 2.36  
    Cases/controls 109/95 106/96 96/95 96/97 69/93  
    Adjusted RR 1.00 0.93 (0.62-1.38) 0.83 (0.54-1.25) 0.77 (0.49-1.21) 0.57 (0.36-0.92) 0.02 
Docosapentaenoic (22:5n-3)       
    Concentration, % 0.77 0.88 0.97 1.06 1.19  
    Cases/controls 114/96 106/94 103/96 79/94 74/96  
    Adjusted RR 1.00 0.93 (0.63-1.37) 0.88 (0.59-1.30) 0.68 (0.45-1.02) 0.60 (0.38-0.93) 0.01 
Docosahexaenoic (22:6n-3)       
    Concentration, % 1.42 1.89 2.19 2.65 3.37  
    Cases/controls 100/95 82/94 119/95 116/97 59/95  
    Adjusted RR 1.00 0.85 (0.57-1.28) 1.22 (0.81-1.84) 1.14 (0.76-1.71) 0.60 (0.39-0.93) 0.07 
Long-chain n-3       
    Concentration, % 3.66 4.44 4.94 5.57 6.70  
    Cases/controls 107/95 105/95 112/94 84/98 68/94  
    Adjusted RR 1.00 0.97 (0.66-1.44) 1.02 (0.67-1.54) 0.74 (0.49-1.13) 0.59 (0.38-0.93) 0.01 
       
n-6/n-3 ratios       
Linoleic/α-linolenic       
    Ratio 45.8 62.0 70.8 82.8 103.7  
    Cases/controls 111/96 107/93 99/94 71/97 88/96  
    Adjusted RR 1.00 1.01 (0.67-1.52) 0.91 (0.62-1.33) 0.61 (0.40-0.94) 0.80 (0.54-1.19) 0.08 
Arachidonic/eicosapentaenoic       
    Ratio 4.18 5.08 5.66 6.42 7.64  
    Cases/controls 80/94 86/97 99/95 116/96 95/94  
    Adjusted RR 1.00 1.06 (0.69-1.63) 1.26 (0.83-1.91) 1.52 (0.98-2.37) 1.30 (0.80-2.11) 0.14 
*

Calculated with median fatty acid concentration in each quintile as a continuous variable.

Adjusted for matching factors (age, smoking status at baseline, and length of follow-up).

Eicosapentaenoic acid + Docosapentaenoic acid + Docosahexaenoic acid.

Close Modal

or Create an Account

Close Modal
Close Modal