Skip to Main Content
Table 3.

RR (95% CI) for prostate cancer by control quintiles of whole blood fatty acid levels

Quintile of fatty acid level
Ptrend*
1 (reference)2345
n-6 Fatty acids       
Linoleic (18:2n-6)       
    Concentration, % 21.4 23.7 25.3 26.7 28.8  
    Cases/controls 121/96 94/96 99/96 85/94 77/94  
    Adjusted RR† 1.00 0.73 (0.49-1.11) 0.77 (0.52-1.16) 0.68 (0.45-1.03) 0.62 (0.41-0.95) 0.03 
γ-Linolenic (18:3n-6)       
    Concentration, % 0.15 0.22 0.26 0.32 0.40  
    Cases/controls 88/94 79/97 94/95 92/95 123/95  
    Adjusted RR† 1.00 0.87 (0.57-1.33) 1.05 (0.69-1.60) 1.04 (0.68-1.57) 1.41 (0.94-2.12) 0.05 
Dihomo-γ-linolenic (20:3n-6)       
    Concentration, % 1.07 1.24 1.36 1.49 1.75  
    Cases/controls 83/94 89/94 81/95 93/96 130/97  
    Adjusted RR† 1.00 1.06 (0.70-1.60) 0.97 (0.63-1.49) 1.11 (0.74-1.66) 1.54 (1.03-2.30) 0.02 
Arachidonic (20:4n-6)       
    Concentration, % 7.9 9.3 10.1 10.9 12.3  
    Cases/controls 90/96 110/96 93/95 86/94 97/95  
    Adjusted RR† 1.00 1.22 (0.82-1.81) 1.05 (0.70-1.57) 0.98 (0.66-1.46) 1.09 (0.72-1.64) 0.98 
       
n-3 Fatty acids       
α-Linolenic (18:3n-3)       
    Concentration, % 0.24 0.30 0.35 0.41 0.54  
    Cases/controls 83/97 97/96 98/94 90/95 108/94  
    Adjusted RR† 1.00 1.17 (0.78-1.75) 1.19 (0.81-1.76) 1.10 (0.73-1.65) 1.31 (0.89-1.95) 0.24 
Eicosapentaenoic (20:5n-3)       
    Concentration, % 1.28 1.58 1.79 1.99 2.36  
    Cases/controls 109/95 106/96 96/95 96/97 69/93  
    Adjusted RR† 1.00 0.93 (0.62-1.38) 0.83 (0.54-1.25) 0.77 (0.49-1.21) 0.57 (0.36-0.92) 0.02 
Docosapentaenoic (22:5n-3)       
    Concentration, % 0.77 0.88 0.97 1.06 1.19  
    Cases/controls 114/96 106/94 103/96 79/94 74/96  
    Adjusted RR† 1.00 0.93 (0.63-1.37) 0.88 (0.59-1.30) 0.68 (0.45-1.02) 0.60 (0.38-0.93) 0.01 
Docosahexaenoic (22:6n-3)       
    Concentration, % 1.42 1.89 2.19 2.65 3.37  
    Cases/controls 100/95 82/94 119/95 116/97 59/95  
    Adjusted RR† 1.00 0.85 (0.57-1.28) 1.22 (0.81-1.84) 1.14 (0.76-1.71) 0.60 (0.39-0.93) 0.07 
Long-chain n-3‡       
    Concentration, % 3.66 4.44 4.94 5.57 6.70  
    Cases/controls 107/95 105/95 112/94 84/98 68/94  
    Adjusted RR† 1.00 0.97 (0.66-1.44) 1.02 (0.67-1.54) 0.74 (0.49-1.13) 0.59 (0.38-0.93) 0.01 
       
n-6/n-3 ratios       
Linoleic/α-linolenic       
    Ratio 45.8 62.0 70.8 82.8 103.7  
    Cases/controls 111/96 107/93 99/94 71/97 88/96  
    Adjusted RR† 1.00 1.01 (0.67-1.52) 0.91 (0.62-1.33) 0.61 (0.40-0.94) 0.80 (0.54-1.19) 0.08 
Arachidonic/eicosapentaenoic       
    Ratio 4.18 5.08 5.66 6.42 7.64  
    Cases/controls 80/94 86/97 99/95 116/96 95/94  
    Adjusted RR† 1.00 1.06 (0.69-1.63) 1.26 (0.83-1.91) 1.52 (0.98-2.37) 1.30 (0.80-2.11) 0.14 
Quintile of fatty acid level
Ptrend*
1 (reference)2345
n-6 Fatty acids       
Linoleic (18:2n-6)       
    Concentration, % 21.4 23.7 25.3 26.7 28.8  
    Cases/controls 121/96 94/96 99/96 85/94 77/94  
    Adjusted RR† 1.00 0.73 (0.49-1.11) 0.77 (0.52-1.16) 0.68 (0.45-1.03) 0.62 (0.41-0.95) 0.03 
γ-Linolenic (18:3n-6)       
    Concentration, % 0.15 0.22 0.26 0.32 0.40  
    Cases/controls 88/94 79/97 94/95 92/95 123/95  
    Adjusted RR† 1.00 0.87 (0.57-1.33) 1.05 (0.69-1.60) 1.04 (0.68-1.57) 1.41 (0.94-2.12) 0.05 
Dihomo-γ-linolenic (20:3n-6)       
    Concentration, % 1.07 1.24 1.36 1.49 1.75  
    Cases/controls 83/94 89/94 81/95 93/96 130/97  
    Adjusted RR† 1.00 1.06 (0.70-1.60) 0.97 (0.63-1.49) 1.11 (0.74-1.66) 1.54 (1.03-2.30) 0.02 
Arachidonic (20:4n-6)       
    Concentration, % 7.9 9.3 10.1 10.9 12.3  
    Cases/controls 90/96 110/96 93/95 86/94 97/95  
    Adjusted RR† 1.00 1.22 (0.82-1.81) 1.05 (0.70-1.57) 0.98 (0.66-1.46) 1.09 (0.72-1.64) 0.98 
       
n-3 Fatty acids       
α-Linolenic (18:3n-3)       
    Concentration, % 0.24 0.30 0.35 0.41 0.54  
    Cases/controls 83/97 97/96 98/94 90/95 108/94  
    Adjusted RR† 1.00 1.17 (0.78-1.75) 1.19 (0.81-1.76) 1.10 (0.73-1.65) 1.31 (0.89-1.95) 0.24 
Eicosapentaenoic (20:5n-3)       
    Concentration, % 1.28 1.58 1.79 1.99 2.36  
    Cases/controls 109/95 106/96 96/95 96/97 69/93  
    Adjusted RR† 1.00 0.93 (0.62-1.38) 0.83 (0.54-1.25) 0.77 (0.49-1.21) 0.57 (0.36-0.92) 0.02 
Docosapentaenoic (22:5n-3)       
    Concentration, % 0.77 0.88 0.97 1.06 1.19  
    Cases/controls 114/96 106/94 103/96 79/94 74/96  
    Adjusted RR† 1.00 0.93 (0.63-1.37) 0.88 (0.59-1.30) 0.68 (0.45-1.02) 0.60 (0.38-0.93) 0.01 
Docosahexaenoic (22:6n-3)       
    Concentration, % 1.42 1.89 2.19 2.65 3.37  
    Cases/controls 100/95 82/94 119/95 116/97 59/95  
    Adjusted RR† 1.00 0.85 (0.57-1.28) 1.22 (0.81-1.84) 1.14 (0.76-1.71) 0.60 (0.39-0.93) 0.07 
Long-chain n-3‡       
    Concentration, % 3.66 4.44 4.94 5.57 6.70  
    Cases/controls 107/95 105/95 112/94 84/98 68/94  
    Adjusted RR† 1.00 0.97 (0.66-1.44) 1.02 (0.67-1.54) 0.74 (0.49-1.13) 0.59 (0.38-0.93) 0.01 
       
n-6/n-3 ratios       
Linoleic/α-linolenic       
    Ratio 45.8 62.0 70.8 82.8 103.7  
    Cases/controls 111/96 107/93 99/94 71/97 88/96  
    Adjusted RR† 1.00 1.01 (0.67-1.52) 0.91 (0.62-1.33) 0.61 (0.40-0.94) 0.80 (0.54-1.19) 0.08 
Arachidonic/eicosapentaenoic       
    Ratio 4.18 5.08 5.66 6.42 7.64  
    Cases/controls 80/94 86/97 99/95 116/96 95/94  
    Adjusted RR† 1.00 1.06 (0.69-1.63) 1.26 (0.83-1.91) 1.52 (0.98-2.37) 1.30 (0.80-2.11) 0.14 
*

Calculated with median fatty acid concentration in each quintile as a continuous variable.

†

Adjusted for matching factors (age, smoking status at baseline, and length of follow-up).

‡

Eicosapentaenoic acid + Docosapentaenoic acid + Docosahexaenoic acid.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept