American Association for Cancer Research

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Table 3.

Number of first-degree relatives with cancer and risk of lung cancer among nonsmokers

	Cases	Person-years	RR* (95% CI)
Any cancer
1	31	105.88	0.86 (0.58-1.27)
2	12	29.14	1.95 (1.08-3.54)
3+	3	12.48	3.17 (1.00-10.03)
P_trend			0.0016
Tobacco-related cancers^†
1	16	59.93	1.07 (0.64-1.79)
2	2	7.64	2.03 (0.50-8.19)
3+	0
P_trend			0.4606

	Cases	Person-years	RR* (95% CI)
Any cancer
1	31	105.88	0.86 (0.58-1.27)
2	12	29.14	1.95 (1.08-3.54)
3+	3	12.48	3.17 (1.00-10.03)
P_trend			0.0016
Tobacco-related cancers^†
1	16	59.93	1.07 (0.64-1.79)
2	2	7.64	2.03 (0.50-8.19)
3+	0
P_trend			0.4606

Adjusted for age, passive smoking, number of siblings, and number of children.

Tobacco related cancers including cancer of the lung, oral cavity, pharynx, esophagus, pancreas, bladder, and kidney.