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Table 3.

Cardiovascular biomarkers while smoking reduced nicotine cigarettes

Week 1, mean (95% CI)Week 6, mean (95% CI)Week 10, mean (95% CI)% difference week 6 versus week 1, mean (95% CI)% difference week 10 versus week 1, mean (95% CI)% difference week 10 versus week 6, mean (95% CI)
Body weight (kg) 71.4 (65.8-77.1) 72.3 (66.7-78.0) 72.0 (66.4-77.7) 1 (0-2) 1 (0-2) 0 (−1-1) 
Systolic blood pressure (mm Hg) 122 (116-129) 124 (116-132) 123 (117-130) 1 (−4-7) 1 (−5-7) −1 (−8-7) 
Diastolic blood pressure (mm Hg) 79.0 (73.4-84.6) 76.6 (71.9-81.2) 78.8 (74.9-82.8) −3 (−10-4) 0 (−9-8) 3 (−3-9) 
Heart rate 76.0 (71.2-80.7) 72.9 (67.2-78.5) 79.8 (73.7-86.0) −4 (−12-3) 5 (−6-16) 10 (−3-22) 
WBC count (1,000) 7.3 (6.5-8.2) 7.7 (6.9-8.4) 7.6 (6.5-8.8) 4 (−6-15) 4 (−11-20) 0 (−15-15) 
Hemoglobin (%) 14.7 (14.1-15.2) 14.4 (13.8-14.9) 14.4 (13.9-14.9) −2 (−4-0) −2 (−4-0) 0 (−2-2) 
HDL cholesterol (ng/dL) 49.9 (40.9-58.8) 51.2 (43.3-59.0) 51.5 (42.3-60.7) 3 (−7-12) 3 (−6-13) 1 (−9-10) 
C-reactive protein* (mcg/mL) 1.00 (0.59-1.68) 1.32 (0.72-2.42) 1.25 (0.67-2.35) 33 (−26-136) 26 (−36-148) −5 (−57-107) 
sICAM* (ng/mL) 241 (219-265) 253 (219-293) 229 (207-253) 5 (−6-18) −5 (−12-2) −10 (−18-0) 
Fibrinogen *, (mg/dL) 247 (223–273) 263 (232-298) 259 (243-275) 7 (−4-18) 5 (−9-21) −2 (−16-16) 
IL-6* (pg/mL) 1.02 (0.76-1.37) 0.97 (0.71-1.31) 1.16 (0.77-1.74) −5 (−26-22) 14 (−28-80) 20 (−19-77) 
P-selectin* (ng/mL) 40 (35-45) 41 (35-48) 40 (35-46) 3 (−6-13) 1 (−5-7) −3 (−14-10) 
Week 1, mean (95% CI)Week 6, mean (95% CI)Week 10, mean (95% CI)% difference week 6 versus week 1, mean (95% CI)% difference week 10 versus week 1, mean (95% CI)% difference week 10 versus week 6, mean (95% CI)
Body weight (kg) 71.4 (65.8-77.1) 72.3 (66.7-78.0) 72.0 (66.4-77.7) 1 (0-2) 1 (0-2) 0 (−1-1) 
Systolic blood pressure (mm Hg) 122 (116-129) 124 (116-132) 123 (117-130) 1 (−4-7) 1 (−5-7) −1 (−8-7) 
Diastolic blood pressure (mm Hg) 79.0 (73.4-84.6) 76.6 (71.9-81.2) 78.8 (74.9-82.8) −3 (−10-4) 0 (−9-8) 3 (−3-9) 
Heart rate 76.0 (71.2-80.7) 72.9 (67.2-78.5) 79.8 (73.7-86.0) −4 (−12-3) 5 (−6-16) 10 (−3-22) 
WBC count (1,000) 7.3 (6.5-8.2) 7.7 (6.9-8.4) 7.6 (6.5-8.8) 4 (−6-15) 4 (−11-20) 0 (−15-15) 
Hemoglobin (%) 14.7 (14.1-15.2) 14.4 (13.8-14.9) 14.4 (13.9-14.9) −2 (−4-0) −2 (−4-0) 0 (−2-2) 
HDL cholesterol (ng/dL) 49.9 (40.9-58.8) 51.2 (43.3-59.0) 51.5 (42.3-60.7) 3 (−7-12) 3 (−6-13) 1 (−9-10) 
C-reactive protein* (mcg/mL) 1.00 (0.59-1.68) 1.32 (0.72-2.42) 1.25 (0.67-2.35) 33 (−26-136) 26 (−36-148) −5 (−57-107) 
sICAM* (ng/mL) 241 (219-265) 253 (219-293) 229 (207-253) 5 (−6-18) −5 (−12-2) −10 (−18-0) 
Fibrinogen *, (mg/dL) 247 (223–273) 263 (232-298) 259 (243-275) 7 (−4-18) 5 (−9-21) −2 (−16-16) 
IL-6* (pg/mL) 1.02 (0.76-1.37) 0.97 (0.71-1.31) 1.16 (0.77-1.74) −5 (−26-22) 14 (−28-80) 20 (−19-77) 
P-selectin* (ng/mL) 40 (35-45) 41 (35-48) 40 (35-46) 3 (−6-13) 1 (−5-7) −3 (−14-10) 

NOTE: Week 1 is while smoking usual brand. Week 6 is while smoking the lowest RNC cigarette (1 mg). Week 10 is 4 weeks after the end of RNC smoking. Values in bold indicate significant differences (P < 0.05).

*

Geometric means.

n = 11.

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