Cardiovascular biomarkers while smoking reduced nicotine cigarettes
| . | Week 1, mean (95% CI) . | Week 6, mean (95% CI) . | Week 10, mean (95% CI) . | % difference week 6 versus week 1, mean (95% CI) . | % difference week 10 versus week 1, mean (95% CI) . | % difference week 10 versus week 6, mean (95% CI) . |
|---|---|---|---|---|---|---|
| Body weight (kg) | 71.4 (65.8-77.1) | 72.3 (66.7-78.0) | 72.0 (66.4-77.7) | 1 (0-2) | 1 (0-2) | 0 (−1-1) |
| Systolic blood pressure (mm Hg) | 122 (116-129) | 124 (116-132) | 123 (117-130) | 1 (−4-7) | 1 (−5-7) | −1 (−8-7) |
| Diastolic blood pressure (mm Hg) | 79.0 (73.4-84.6) | 76.6 (71.9-81.2) | 78.8 (74.9-82.8) | −3 (−10-4) | 0 (−9-8) | 3 (−3-9) |
| Heart rate | 76.0 (71.2-80.7) | 72.9 (67.2-78.5) | 79.8 (73.7-86.0) | −4 (−12-3) | 5 (−6-16) | 10 (−3-22) |
| WBC count (1,000) | 7.3 (6.5-8.2) | 7.7 (6.9-8.4) | 7.6 (6.5-8.8) | 4 (−6-15) | 4 (−11-20) | 0 (−15-15) |
| Hemoglobin (%) | 14.7 (14.1-15.2) | 14.4 (13.8-14.9) | 14.4 (13.9-14.9) | −2 (−4-0) | −2 (−4-0) | 0 (−2-2) |
| HDL cholesterol (ng/dL) | 49.9 (40.9-58.8) | 51.2 (43.3-59.0) | 51.5 (42.3-60.7) | 3 (−7-12) | 3 (−6-13) | 1 (−9-10) |
| C-reactive protein* (mcg/mL) | 1.00 (0.59-1.68) | 1.32 (0.72-2.42) | 1.25 (0.67-2.35) | 33 (−26-136) | 26 (−36-148) | −5 (−57-107) |
| sICAM* (ng/mL) | 241 (219-265) | 253 (219-293) | 229 (207-253) | 5 (−6-18) | −5 (−12-2) | −10 (−18-0) |
| Fibrinogen *,† (mg/dL) | 247 (223–273) | 263 (232-298) | 259 (243-275) | 7 (−4-18) | 5 (−9-21) | −2 (−16-16) |
| IL-6* (pg/mL) | 1.02 (0.76-1.37) | 0.97 (0.71-1.31) | 1.16 (0.77-1.74) | −5 (−26-22) | 14 (−28-80) | 20 (−19-77) |
| P-selectin* (ng/mL) | 40 (35-45) | 41 (35-48) | 40 (35-46) | 3 (−6-13) | 1 (−5-7) | −3 (−14-10) |
| . | Week 1, mean (95% CI) . | Week 6, mean (95% CI) . | Week 10, mean (95% CI) . | % difference week 6 versus week 1, mean (95% CI) . | % difference week 10 versus week 1, mean (95% CI) . | % difference week 10 versus week 6, mean (95% CI) . |
|---|---|---|---|---|---|---|
| Body weight (kg) | 71.4 (65.8-77.1) | 72.3 (66.7-78.0) | 72.0 (66.4-77.7) | 1 (0-2) | 1 (0-2) | 0 (−1-1) |
| Systolic blood pressure (mm Hg) | 122 (116-129) | 124 (116-132) | 123 (117-130) | 1 (−4-7) | 1 (−5-7) | −1 (−8-7) |
| Diastolic blood pressure (mm Hg) | 79.0 (73.4-84.6) | 76.6 (71.9-81.2) | 78.8 (74.9-82.8) | −3 (−10-4) | 0 (−9-8) | 3 (−3-9) |
| Heart rate | 76.0 (71.2-80.7) | 72.9 (67.2-78.5) | 79.8 (73.7-86.0) | −4 (−12-3) | 5 (−6-16) | 10 (−3-22) |
| WBC count (1,000) | 7.3 (6.5-8.2) | 7.7 (6.9-8.4) | 7.6 (6.5-8.8) | 4 (−6-15) | 4 (−11-20) | 0 (−15-15) |
| Hemoglobin (%) | 14.7 (14.1-15.2) | 14.4 (13.8-14.9) | 14.4 (13.9-14.9) | −2 (−4-0) | −2 (−4-0) | 0 (−2-2) |
| HDL cholesterol (ng/dL) | 49.9 (40.9-58.8) | 51.2 (43.3-59.0) | 51.5 (42.3-60.7) | 3 (−7-12) | 3 (−6-13) | 1 (−9-10) |
| C-reactive protein* (mcg/mL) | 1.00 (0.59-1.68) | 1.32 (0.72-2.42) | 1.25 (0.67-2.35) | 33 (−26-136) | 26 (−36-148) | −5 (−57-107) |
| sICAM* (ng/mL) | 241 (219-265) | 253 (219-293) | 229 (207-253) | 5 (−6-18) | −5 (−12-2) | −10 (−18-0) |
| Fibrinogen *,† (mg/dL) | 247 (223–273) | 263 (232-298) | 259 (243-275) | 7 (−4-18) | 5 (−9-21) | −2 (−16-16) |
| IL-6* (pg/mL) | 1.02 (0.76-1.37) | 0.97 (0.71-1.31) | 1.16 (0.77-1.74) | −5 (−26-22) | 14 (−28-80) | 20 (−19-77) |
| P-selectin* (ng/mL) | 40 (35-45) | 41 (35-48) | 40 (35-46) | 3 (−6-13) | 1 (−5-7) | −3 (−14-10) |