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Table 2.

Smoking behavior and chemical exposures while smoking reduced nicotine cigarettes

Week 1, mean (95% CI)Week 6, mean (95% CI)Week 10, mean (95% CI)% difference week 6 versus week 1, mean (95% CI)% difference week 10 versus week 1, mean (95% CI)% difference week 10 versus week 6, mean (95% CI)
Cigarettes per day 18.9 (15.5-22.3) 17.7 (10.4-25.0) 10.1 (6.2-14.0) −6 (−37-24) 47 (−63 to −30) 43 (−80 to −6) 
Pre-smoking plasma nicotine (ng/mL) 13.0 (10.2-15.7) 3.8 (1.6-6.1) 8.3 (4.1-12.4) 70 (−101 to −40) −36 (−76-4) 115 (28-202) 
Nicotine boost (ng/mL) 8.2 (5.4-11.1) 1.0 (0.6-1.4) NM 88 (−122 to −54) NM NM 
Blood COHB (%) 3.2 (2.6-3.9) 3.6 (2.3-4.9) 2.1 (1.2-3.0) 11 (−22-45) 35 (−64 to −7) 42 (−66 to −18) 
Plasma cotinine (ng/mL) 194 (152-235) 62 (28-96) 109 (64-153) 68 (−93 to −43) 44 (−63 to −25) 75 (9-142) 
Total NNAL* (pmol/mg creat) 1.17 (0.79-1.73) 0.92 (0.58-1.44) 0.53 (0.29-0.95) 22 (−38-0) 55 (−71 to −32) 43 (−60 to −17) 
1-OH-pyrene* (pmol/mg creat) 0.97 (0.62-1.33) 1.06 (0.80-1.50) 0.89 (0.62-1.33) 18 (−12-57) −6 (−44-56) −20 (−46-16) 
2-Naphthol* (pmol/mg creat) 77.9 (62.0-97.4) 80.5 (62.0-104.4) 57.5 (43.4-77.0) 3 (−23-37) 26 (−43 to −5) 28 (−48 to −1) 
Sum of hydroxyphenanthrene isomers* (pmol/mg creat) 2.4 (1.8-3.4) 2.6 (1.9-3.4) 2.6 (1.7-3.8) 6 (−23-45) 5 (−25-47) −1 (−24-30) 
2-Hydroxyfluorene* (pmol/mg creat) 6.9 (5.1-9.3) 7.8 (5.8-10.6) 4.7 (2.9-7.7) 13 (−15-50) −32 (−58-11) 39 (−60 to −9) 
Week 1, mean (95% CI)Week 6, mean (95% CI)Week 10, mean (95% CI)% difference week 6 versus week 1, mean (95% CI)% difference week 10 versus week 1, mean (95% CI)% difference week 10 versus week 6, mean (95% CI)
Cigarettes per day 18.9 (15.5-22.3) 17.7 (10.4-25.0) 10.1 (6.2-14.0) −6 (−37-24) 47 (−63 to −30) 43 (−80 to −6) 
Pre-smoking plasma nicotine (ng/mL) 13.0 (10.2-15.7) 3.8 (1.6-6.1) 8.3 (4.1-12.4) 70 (−101 to −40) −36 (−76-4) 115 (28-202) 
Nicotine boost (ng/mL) 8.2 (5.4-11.1) 1.0 (0.6-1.4) NM 88 (−122 to −54) NM NM 
Blood COHB (%) 3.2 (2.6-3.9) 3.6 (2.3-4.9) 2.1 (1.2-3.0) 11 (−22-45) 35 (−64 to −7) 42 (−66 to −18) 
Plasma cotinine (ng/mL) 194 (152-235) 62 (28-96) 109 (64-153) 68 (−93 to −43) 44 (−63 to −25) 75 (9-142) 
Total NNAL* (pmol/mg creat) 1.17 (0.79-1.73) 0.92 (0.58-1.44) 0.53 (0.29-0.95) 22 (−38-0) 55 (−71 to −32) 43 (−60 to −17) 
1-OH-pyrene* (pmol/mg creat) 0.97 (0.62-1.33) 1.06 (0.80-1.50) 0.89 (0.62-1.33) 18 (−12-57) −6 (−44-56) −20 (−46-16) 
2-Naphthol* (pmol/mg creat) 77.9 (62.0-97.4) 80.5 (62.0-104.4) 57.5 (43.4-77.0) 3 (−23-37) 26 (−43 to −5) 28 (−48 to −1) 
Sum of hydroxyphenanthrene isomers* (pmol/mg creat) 2.4 (1.8-3.4) 2.6 (1.9-3.4) 2.6 (1.7-3.8) 6 (−23-45) 5 (−25-47) −1 (−24-30) 
2-Hydroxyfluorene* (pmol/mg creat) 6.9 (5.1-9.3) 7.8 (5.8-10.6) 4.7 (2.9-7.7) 13 (−15-50) −32 (−58-11) 39 (−60 to −9) 

NOTE: Week 1 is while smoking usual brand. Week 6 is while smoking the lowest RNC cigarette (1 mg). Week 10 is 4 weeks after the end of RNC smoking. Values in bold indicate significant differences (P < 0.05).

*

Geometric means; NM = not measured; creat = creatinine.

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