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Table 4.

Polymorphisms in IGF-I and IGFBP-3 in relation to serum concentrations of their protein products at baseline

	n*	Arithmetic mean (SD)	Arithmetic mean (SD)
IGF-I (CA)₁₉ genotypes		IGF-I (ng/mL)	IGF-I (ng/mL), adjusted^†
(CA)₁₉/(CA)₁₉	136 (40%)	180 (78)	178 (79)
(CA)₁₉/(CA)_non-19	166 (48%)	205 (87)	193 (79)
(CA)_non-19/(CA)_non-19	41 (12%)	190 (99)	209 (80)
P^‡		0.04	0.01
Overall mean		193 (86)
IGFBP-3 −202 A/C genotypes		IGFBP-3 (ng/mL)	IGFBP-3 (ng/mL), adjusted^†
AA	65 (19%)	3,897 (806)	3,819 (822)
AC	171 (50%)	3,611 (907)	3,602 (819)
CC	107 (31%)	3,478 (834)	3,384 (821)
P^‡		0.009	0.002
Overall mean		3624 (876)

	n*	Arithmetic mean (SD)	Arithmetic mean (SD)
IGF-I (CA)₁₉ genotypes		IGF-I (ng/mL)	IGF-I (ng/mL), adjusted^†
(CA)₁₉/(CA)₁₉	136 (40%)	180 (78)	178 (79)
(CA)₁₉/(CA)_non-19	166 (48%)	205 (87)	193 (79)
(CA)_non-19/(CA)_non-19	41 (12%)	190 (99)	209 (80)
P^‡		0.04	0.01
Overall mean		193 (86)
IGFBP-3 −202 A/C genotypes		IGFBP-3 (ng/mL)	IGFBP-3 (ng/mL), adjusted^†
AA	65 (19%)	3,897 (806)	3,819 (822)
AC	171 (50%)	3,611 (907)	3,602 (819)
CC	107 (31%)	3,478 (834)	3,384 (821)
P^‡		0.009	0.002
Overall mean		3624 (876)

Total n = 343.

Adjustment for age and gender.

ANOVA (F statistics) for difference in means.