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Table 4.

Polymorphisms in IGF-I and IGFBP-3 in relation to serum concentrations of their protein products at baseline

n*Arithmetic mean (SD)Arithmetic mean (SD)
IGF-I (CA)19 genotypes  IGF-I (ng/mL) IGF-I (ng/mL), adjusted 
    (CA)19/(CA)19 136 (40%) 180 (78) 178 (79) 
    (CA)19/(CA)non-19 166 (48%) 205 (87) 193 (79) 
    (CA)non-19/(CA)non-19 41 (12%) 190 (99) 209 (80) 
    P  0.04 0.01 
    Overall mean  193 (86)  
IGFBP-3 −202 A/C genotypes  IGFBP-3 (ng/mL) IGFBP-3 (ng/mL), adjusted 
    AA 65 (19%) 3,897 (806) 3,819 (822) 
    AC 171 (50%) 3,611 (907) 3,602 (819) 
    CC 107 (31%) 3,478 (834) 3,384 (821) 
    P  0.009 0.002 
    Overall mean  3624 (876)  
n*Arithmetic mean (SD)Arithmetic mean (SD)
IGF-I (CA)19 genotypes  IGF-I (ng/mL) IGF-I (ng/mL), adjusted 
    (CA)19/(CA)19 136 (40%) 180 (78) 178 (79) 
    (CA)19/(CA)non-19 166 (48%) 205 (87) 193 (79) 
    (CA)non-19/(CA)non-19 41 (12%) 190 (99) 209 (80) 
    P  0.04 0.01 
    Overall mean  193 (86)  
IGFBP-3 −202 A/C genotypes  IGFBP-3 (ng/mL) IGFBP-3 (ng/mL), adjusted 
    AA 65 (19%) 3,897 (806) 3,819 (822) 
    AC 171 (50%) 3,611 (907) 3,602 (819) 
    CC 107 (31%) 3,478 (834) 3,384 (821) 
    P  0.009 0.002 
    Overall mean  3624 (876)  
*

Total n = 343.

Adjustment for age and gender.

ANOVA (F statistics) for difference in means.

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