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Table 1.

Nrf2, NQO1, NOS3, and HO-1 genotype and breast cancer risk

PolymorphismAge-adjusted model*
Fully adjusted model
CaCoOR (95% CI)CaCoOR (95% CIs)
Nrf2       
    CC 255 289 1 (referent) 235 259 1 (referent) 
    CT 207 172 1.36 (1.05-1.78) 182 157 1.31 (0.99-1.74) 
    TT 38 40 1.08 (0.67-1.73) 37 38 1.08 (0.66-1.77) 
   P trend = 0.12   P trend = 0.20 
NQO1       
    CC 325 323 1 (referent) 297 293 1 (referent) 
    CT 157 151 1.03 (0.79-1.36) 140 137 1.00 (0.75-1.33) 
    TT 14 21 0.66 (0.33-1.32) 13 18 0.71 (0.34-1.49) 
   P trend = 0.63   P trend = 0.60 
NOS3       
    GG 242 236 1.0 (referent) 218 214 1.0 (referent) 
    GT 200 209 0.94 (0.72-1.22) 179 190 0.95 (0.72-1.26) 
    TT 47 40 1.15 (0.73-1.81) 47 34 1.33 (0.82-2.16) 
   P trend = 0.89   P trend = 0.54 
HO-1       
    LL 176 167 1 (referent) 160 148 1 (referent) 
    LM 57 50 1.08 (0.70-1.67) 54 48 0.98 (0.62-1.55) 
    LS 149 184 0.77 (0.57-1.04) 132 165 0.71 (0.51-0.98) 
    MM 10 11 0.86 (0.36-2.09) 10 0.75 (0.29-1.92) 
    MS 34 33 0.98 (0.58-1.65) 30 52 0.86 (0.49-1.49) 
    SS 52 47 1.05 (0.67-1.64) 46 43 0.94 (0.59-1.52) 
    LS + MM + MS + SS 245 275 1 (referent) 217 250 1 (referent) 
    LL + LM 233 217 1.20 (0.93-1.55) 214 196 1.29 (0.99-1.70) 
High-risk alleles or genotypes§       
    0 47 60 1 (referent) 41 56 1 (referent) 
    1 128 145 1.13 (0.72-1.77) 115 128 1.22 (0.76-1.98) 
    2 172 160 1.37 (0.89-2.13) 156 146 1.45 (0.91-2.31) 
    3+ 155 140 1.41 (0.91-2.21) 143 127 1.56 (0.97-2.51) 
   P trend = 0.06   P trend = 0.04 
PolymorphismAge-adjusted model*
Fully adjusted model
CaCoOR (95% CI)CaCoOR (95% CIs)
Nrf2       
    CC 255 289 1 (referent) 235 259 1 (referent) 
    CT 207 172 1.36 (1.05-1.78) 182 157 1.31 (0.99-1.74) 
    TT 38 40 1.08 (0.67-1.73) 37 38 1.08 (0.66-1.77) 
   P trend = 0.12   P trend = 0.20 
NQO1       
    CC 325 323 1 (referent) 297 293 1 (referent) 
    CT 157 151 1.03 (0.79-1.36) 140 137 1.00 (0.75-1.33) 
    TT 14 21 0.66 (0.33-1.32) 13 18 0.71 (0.34-1.49) 
   P trend = 0.63   P trend = 0.60 
NOS3       
    GG 242 236 1.0 (referent) 218 214 1.0 (referent) 
    GT 200 209 0.94 (0.72-1.22) 179 190 0.95 (0.72-1.26) 
    TT 47 40 1.15 (0.73-1.81) 47 34 1.33 (0.82-2.16) 
   P trend = 0.89   P trend = 0.54 
HO-1       
    LL 176 167 1 (referent) 160 148 1 (referent) 
    LM 57 50 1.08 (0.70-1.67) 54 48 0.98 (0.62-1.55) 
    LS 149 184 0.77 (0.57-1.04) 132 165 0.71 (0.51-0.98) 
    MM 10 11 0.86 (0.36-2.09) 10 0.75 (0.29-1.92) 
    MS 34 33 0.98 (0.58-1.65) 30 52 0.86 (0.49-1.49) 
    SS 52 47 1.05 (0.67-1.64) 46 43 0.94 (0.59-1.52) 
    LS + MM + MS + SS 245 275 1 (referent) 217 250 1 (referent) 
    LL + LM 233 217 1.20 (0.93-1.55) 214 196 1.29 (0.99-1.70) 
High-risk alleles or genotypes§       
    0 47 60 1 (referent) 41 56 1 (referent) 
    1 128 145 1.13 (0.72-1.77) 115 128 1.22 (0.76-1.98) 
    2 172 160 1.37 (0.89-2.13) 156 146 1.45 (0.91-2.31) 
    3+ 155 140 1.41 (0.91-2.21) 143 127 1.56 (0.97-2.51) 
   P trend = 0.06   P trend = 0.04 
*

Adjusted for age.

Fully adjusted model was adjusted for age, family history of breast cancer (yes, no), hormone replacement therapy (yes, no), body mass index (continuous, log transformed), age at menarche, age at menopause, smoking status (ever/never), race (Caucasian, other), and parity (yes/no); 96 participants (48 cases and 48 controls) were excluded from this analysis because of missing covariate information.

OR and 95% CIs calculated by unconditional logistic regression.

§

Sum total of high-risk alleles or genotypes, which were taken to be the Nrf2 T allele, the NQO1 T allele, the NOS3 T allele, and the HO-1 LL and LM genotypes.

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