Nrf2, NQO1, NOS3, and HO-1 genotype and breast cancer risk
| Polymorphism . | Age-adjusted model* . | . | . | Fully adjusted model† . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Ca . | Co . | OR (95% CI)‡ . | Ca . | Co . | OR (95% CIs) . | ||||||
| Nrf2 | ||||||||||||
| CC | 255 | 289 | 1 (referent) | 235 | 259 | 1 (referent) | ||||||
| CT | 207 | 172 | 1.36 (1.05-1.78) | 182 | 157 | 1.31 (0.99-1.74) | ||||||
| TT | 38 | 40 | 1.08 (0.67-1.73) | 37 | 38 | 1.08 (0.66-1.77) | ||||||
| P trend = 0.12 | P trend = 0.20 | |||||||||||
| NQO1 | ||||||||||||
| CC | 325 | 323 | 1 (referent) | 297 | 293 | 1 (referent) | ||||||
| CT | 157 | 151 | 1.03 (0.79-1.36) | 140 | 137 | 1.00 (0.75-1.33) | ||||||
| TT | 14 | 21 | 0.66 (0.33-1.32) | 13 | 18 | 0.71 (0.34-1.49) | ||||||
| P trend = 0.63 | P trend = 0.60 | |||||||||||
| NOS3 | ||||||||||||
| GG | 242 | 236 | 1.0 (referent) | 218 | 214 | 1.0 (referent) | ||||||
| GT | 200 | 209 | 0.94 (0.72-1.22) | 179 | 190 | 0.95 (0.72-1.26) | ||||||
| TT | 47 | 40 | 1.15 (0.73-1.81) | 47 | 34 | 1.33 (0.82-2.16) | ||||||
| P trend = 0.89 | P trend = 0.54 | |||||||||||
| HO-1 | ||||||||||||
| LL | 176 | 167 | 1 (referent) | 160 | 148 | 1 (referent) | ||||||
| LM | 57 | 50 | 1.08 (0.70-1.67) | 54 | 48 | 0.98 (0.62-1.55) | ||||||
| LS | 149 | 184 | 0.77 (0.57-1.04) | 132 | 165 | 0.71 (0.51-0.98) | ||||||
| MM | 10 | 11 | 0.86 (0.36-2.09) | 9 | 10 | 0.75 (0.29-1.92) | ||||||
| MS | 34 | 33 | 0.98 (0.58-1.65) | 30 | 52 | 0.86 (0.49-1.49) | ||||||
| SS | 52 | 47 | 1.05 (0.67-1.64) | 46 | 43 | 0.94 (0.59-1.52) | ||||||
| LS + MM + MS + SS | 245 | 275 | 1 (referent) | 217 | 250 | 1 (referent) | ||||||
| LL + LM | 233 | 217 | 1.20 (0.93-1.55) | 214 | 196 | 1.29 (0.99-1.70) | ||||||
| High-risk alleles or genotypes§ | ||||||||||||
| 0 | 47 | 60 | 1 (referent) | 41 | 56 | 1 (referent) | ||||||
| 1 | 128 | 145 | 1.13 (0.72-1.77) | 115 | 128 | 1.22 (0.76-1.98) | ||||||
| 2 | 172 | 160 | 1.37 (0.89-2.13) | 156 | 146 | 1.45 (0.91-2.31) | ||||||
| 3+ | 155 | 140 | 1.41 (0.91-2.21) | 143 | 127 | 1.56 (0.97-2.51) | ||||||
| P trend = 0.06 | P trend = 0.04 | |||||||||||
| Polymorphism . | Age-adjusted model* . | . | . | Fully adjusted model† . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Ca . | Co . | OR (95% CI)‡ . | Ca . | Co . | OR (95% CIs) . | ||||||
| Nrf2 | ||||||||||||
| CC | 255 | 289 | 1 (referent) | 235 | 259 | 1 (referent) | ||||||
| CT | 207 | 172 | 1.36 (1.05-1.78) | 182 | 157 | 1.31 (0.99-1.74) | ||||||
| TT | 38 | 40 | 1.08 (0.67-1.73) | 37 | 38 | 1.08 (0.66-1.77) | ||||||
| P trend = 0.12 | P trend = 0.20 | |||||||||||
| NQO1 | ||||||||||||
| CC | 325 | 323 | 1 (referent) | 297 | 293 | 1 (referent) | ||||||
| CT | 157 | 151 | 1.03 (0.79-1.36) | 140 | 137 | 1.00 (0.75-1.33) | ||||||
| TT | 14 | 21 | 0.66 (0.33-1.32) | 13 | 18 | 0.71 (0.34-1.49) | ||||||
| P trend = 0.63 | P trend = 0.60 | |||||||||||
| NOS3 | ||||||||||||
| GG | 242 | 236 | 1.0 (referent) | 218 | 214 | 1.0 (referent) | ||||||
| GT | 200 | 209 | 0.94 (0.72-1.22) | 179 | 190 | 0.95 (0.72-1.26) | ||||||
| TT | 47 | 40 | 1.15 (0.73-1.81) | 47 | 34 | 1.33 (0.82-2.16) | ||||||
| P trend = 0.89 | P trend = 0.54 | |||||||||||
| HO-1 | ||||||||||||
| LL | 176 | 167 | 1 (referent) | 160 | 148 | 1 (referent) | ||||||
| LM | 57 | 50 | 1.08 (0.70-1.67) | 54 | 48 | 0.98 (0.62-1.55) | ||||||
| LS | 149 | 184 | 0.77 (0.57-1.04) | 132 | 165 | 0.71 (0.51-0.98) | ||||||
| MM | 10 | 11 | 0.86 (0.36-2.09) | 9 | 10 | 0.75 (0.29-1.92) | ||||||
| MS | 34 | 33 | 0.98 (0.58-1.65) | 30 | 52 | 0.86 (0.49-1.49) | ||||||
| SS | 52 | 47 | 1.05 (0.67-1.64) | 46 | 43 | 0.94 (0.59-1.52) | ||||||
| LS + MM + MS + SS | 245 | 275 | 1 (referent) | 217 | 250 | 1 (referent) | ||||||
| LL + LM | 233 | 217 | 1.20 (0.93-1.55) | 214 | 196 | 1.29 (0.99-1.70) | ||||||
| High-risk alleles or genotypes§ | ||||||||||||
| 0 | 47 | 60 | 1 (referent) | 41 | 56 | 1 (referent) | ||||||
| 1 | 128 | 145 | 1.13 (0.72-1.77) | 115 | 128 | 1.22 (0.76-1.98) | ||||||
| 2 | 172 | 160 | 1.37 (0.89-2.13) | 156 | 146 | 1.45 (0.91-2.31) | ||||||
| 3+ | 155 | 140 | 1.41 (0.91-2.21) | 143 | 127 | 1.56 (0.97-2.51) | ||||||
| P trend = 0.06 | P trend = 0.04 | |||||||||||
Adjusted for age.
Fully adjusted model was adjusted for age, family history of breast cancer (yes, no), hormone replacement therapy (yes, no), body mass index (continuous, log transformed), age at menarche, age at menopause, smoking status (ever/never), race (Caucasian, other), and parity (yes/no); 96 participants (48 cases and 48 controls) were excluded from this analysis because of missing covariate information.
OR and 95% CIs calculated by unconditional logistic regression.
Sum total of high-risk alleles or genotypes, which were taken to be the Nrf2 T allele, the NQO1 T allele, the NOS3 T allele, and the HO-1 LL and LM genotypes.