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Table 3.

Genes differentially expressed in the breast epithelium of parous control women

Gene nameGene IDSymbolGO no.Molecular function GO no.PadjustedFold increase/decrease
Apoptosis       
    BCL2-associated X protein AI565203 BAX GO:0006915 GO:0005515 0.023 2.65 
    CASP2 and RIPK1 AA285065 CRADD GO:0042981 GO:0005515 0.004 1.89 
    TNF receptor–associated factor 1 R71691 TRAF1 GO:0006915 GO:0006461 0.017 1.72 
    TIA1 cytotoxic granule-associated RNA binding protein R82978 TIA1 GO:0006915 GO:0000166 0.017 1.56 
    TNFRSF1A-associated via death domain AA916906 TRADD GO:0006915 GO:0005515 0.027 1.42 
    Protein phosphatase 1F AA806330 PPM1F GO:0006915 GO:0016787 0.014 1.35 
    Mdm4 AI310969 MDM4 GO:0006915 GO:0004842 0.013 −1.25 
    Programmed cell death AA416757 PDCD5 GO:0006915 GO:0005554 0.001 −2.15 
Antiapoptosis       
    Baculoviral inhibitor of apoptosis protein repeat–containing 6 H10434 BIRC6 GO:0006916 GO:0004840 0.013 −1.26 
    BCL2-associated athanogene 4 H22928 BAG4 GO:0006916 GO:0005057 0.026 −1.27 
Cell adhesion       
    Sema domain AA436152 SEMA5A GO:0007155 GO:0004872 0.050 1.81 
    Fibulin 5 H17615 FBLN5 GO:0007160 GO:0004888 0.010 1.79 
    Intercellular adhesion molecule 3 W95068 ICAM3 GO:0016337 GO:0005178 0.019 1.70 
    Formin binding protein 4 N49573 FNBP4 GO:0007155 GO:0005198 0.027 1.29 
    Sidekick homologue 1 (chicken) N23940 SDK1 GO:0007155 GO:0005515 0.026 1.26 
    Epithelial V-like antigen 1 AA668897 EVA1 GO:0007155 GO:0005515 0.011 1.25 
    Neuropilin 1 AA098867 NRP1 GO:0007155 GO:0004872 0.017 1.25 
    Discs, large homologue 5 (DrosophilaAA478949 DLG5 GO:0016337 GO:0005515 0.013 −1.80 
    Collagen, type XVI, α1 AA088202 COL16A1 GO:0007155 GO:0005198 0.010 −1.78 
    Down syndrome cell adhesion molecule N53145 DSCAM GO:0007155 GO:0005515 0.012 −2.10 
    Laminin, γ1 (formerly LAMB2) AA599005 LAMC1 GO:0007155 GO:0005515 0.001 −2.91 
Cell signaling-signal transduction       
    Egf-like module containing AI174266 EMR2 GO:0007165 GO:0004872 0.011 1.51 
    Low-density lipoprotein receptor–related protein 5 R83038 LRP5 GO:0016055 GO:0004872 0.014 1.40 
    G protein–coupled receptor kinase interactor 1 AI079118 GIT1 GO:0008277 GO:0005096 0.012 1.35 
    Insulin receptor substrate 1 AA456306 IRS1 GO:0007165 GO:0004871 0.022 1.29 
    Cornichon homologue 2 (DrosophilaR42919 CNIH2 GO:0007242 GO:0005554 0.010 1.25 
    Ankyrin 2, neuronal AI018106 ANK2 GO:0007165 GO:0005200 0.014 1.25 
    Galanin receptor 2 N75473 GALR2 GO:0007186 GO:0004966 0.030 1.20 
    Development and differentiation enhancing factor 2 AI054096 DDEF2 GO:0043087 GO:0005096 0.013 −1.30 
    BRCA2 and CDKN1A interacting protein AI033172 BCCIP GO:0000079 GO:0005554 0.007 −1.37 
    Rap guanine nucleotide exchange factor (GEF) 6 AA911005 RAPGEF6 GO:0007264 GO:0005085 0.002 −1.40 
    Endothelin receptor type A AA909960 EDNRA GO:0007186 GO:0001599 0.011 −1.45 
    Neuropeptide Y receptor Y1 R43817 NPY1R GO:0007165 GO:0001584 0.019 −1.46 
    Neuropeptide S receptor 1 H91700 NPSR1 GO:0007165 GO:0004872 0.014 −1.46 
    GIPC PDZ domain containing family, member 1 AI094796 GIPC1 GO:0007186 GO:0005515 0.011 −1.55 
    RAB27A, member RAS oncogene family AI309109 RAB27A GO:0007264 GO:0000166 0.005 −1.85 
    Ankyrin repeat and death domain containing 1A AI053438 ANKDD1A GO:0007165 GO:0005515| 0.009 −2.31 
Small inducible cytokine subfamily E H05323 SCYE1 GO:0007267 GO:0005125 0.002 −3.87 
    Coiled-coil domain containing 132 R49442 CCDC132 GO:0000160 GO:0000155 0.002 −3.89 
Cell cycle and growth       
    Homeodomain interacting protein kinase 2 N38891 HIPK2 GO:0000074 GO:0000166 0.007 1.87 
    Retinoblastoma binding protein 6 AA398302 RBBP6 GO:0000074 GO:0003676 0.012 1.58 
    DnaJ (Hsp40) homologue, subfamily A, member 2 AI273537 DNAJA2 GO:0000074 GO:0008270 0.002 1.56 
    Dynactin 1 (p150, glued homologue, DrosophilaAA488168 DCTN1 GO:0007067 GO:0003774 0.011 1.48 
    Transmembrane and coiled-coil domains 7 AI057241 TMCO7 GO:0007076 GO:0005488 0.011 −1.60 
    Sestrin 3 AI190194 SESN3 GO:0007050 GO:0005554 0.002 −1.90 
    LATS, large tumor suppressor, homologue 1 AI023733 LATS1 GO:0000086 GO:0000166 0.009 −1.98 
    Transforming, acidic coiled-coil containing protein 1 AA598796 TACC1 GO:0007049 GO:0005515 0.007 −2.17 
    Protein phosphatase 2 H09640 PPP2R1B GO:0000074 GO:0000158 0.019 −2.35 
    Katanin p60 subunit A 1 T47614 KATNA1 GO:0007049 GO:0000166 0.005 −2.66 
    G1 to S phase transition 1 R62452 GSPT1 GO:0000082 GO:0000166 0.000 −3.50 
Response to exogenous agents       
    Chromosome 10 open reading frame 59 AI093491 C10orf59 GO:0006725 GO:0004497 0.013 1.93 
    Thioredoxin reductase 1 AA464849 TXNRD1 GO:0045454 GO:0015036 0.006 1.92 
    Epoxide hydrolase 1, microsomal (xenobiotic) AA838691 EPHX1 GO:0006805 GO:0004301 0.012 1.78 
    Retinol dehydrogenase 11 (all-trans/9-cis/11-cisH82421 RDH11 GO:0008152 GO:0016491 0.016 1.64 
    N-Acetyltransferase 2 (arylamine N-acetyltransferase) AI460128 NAT2 GO:0008152 GO:0004060 0.009 1.50 
    Immunoglobulin (CD79A) binding protein 1 AA463498 IGBP1 GO:0042113 GO:0008601 0.005 1.38 
    Calcium binding atopy-related autoantigen 1 AA992324 CBARA1 GO:0006952 GO:0005509 0.013 1.38 
    Toll-interleukin 1 receptor AI279454 TIRAP GO:0006954 GO:0004888 0.009 1.38 
    Epoxide hydrolase 1, microsomal (xenobiotic) AA838691 EPHX1 GO:0006805 GO:0004301 0.012 1.25 
    Glutathione S-transferase 𝛉1 T64869 GSTT1 GO:0006950 GO:0004364 0.013 1.24 
Cell transport       
    Armadillo repeat containing 1 AA490502 ARMC1 GO:0030001 GO:0046872 0.0122 1.65 
    Solute carrier family 19, member 3 AA707858 SLC19A3 GO:0006810 GO:0005386 0.0232 1.64 
    Translocation protein 1 T98628 TLOC1 GO:0015031 GO:0004872 0.0120 1.63 
    SH3KBP1 binding protein 1 AA457723 SHKBP1 GO:0006813 GO:0005216 0.0232 1.63 
    Tweety homologue 1 (DrosophilaR56769 TTYH1 GO:0006826 GO:0005381 0.0232 1.60 
    Solute carrier family 22 AA705565 SLC22A9 GO:0006810 GO:0005215 0.0119 1.56 
    Translocated promoter region AA064778 TPR GO:0006810 GO:0005554 0.0069 1.53 
    UDP-N-acetyl-α-d-galactosamine AA598949 GALNT10 GO:0005794 GO:0003779 0.0071 1.47 
    HIV-1 Rev binding protein AA927604 HRB GO:0006406 GO:0003677 0.0124 1.40 
    Chloride channel 6 H72322 CLCN6 GO:0006811 GO:0005247 0.0220 1.35 
    Transient receptor potential cation channel AI167481 TRPM1 GO:0006812 GO:0005262 0.0144 1.24 
    Dysbindin domain containing 2 AA598970 DBNDD2 GO:0015031 GO:0005515 0.0247 −1.31 
    Frequenin homologue (DrosophilaH16821 FREQ GO:0005794 GO:0005509 0.0174 −1.42 
    Sorting nexin 11 H16467 SNX11 GO:0007242 GO:0005554 0.0247 −1.46 
    Acyl-CoA oxidase 1, palmitoyl AI079148 ACOX1 GO:0006118 GO:0003995 0.0101 −1.53 
    Ficolin (collagen/fibrinogen domain containing) 1 AI349250 FCN1 GO:0006817 GO:0003823 0.0084 −1.66 
    Cytochrome b5 reductase 4 AI053851 CYB5R4 GO:0006118 GO:0004128 0.0139 −1.70 
    Solute carrier family 20 (phosphate transporter) AA933776 SLC20A2 GO:0006810 GO:0004872 0.0108 −1.71 
    Stonin 2 AA992626 STON2 GO:0006886 GO:0005515 0.0056 −1.72 
    RAP1B, member of RAS oncogene family AA598864 RAP1B GO:0006886 GO:0005525 0.0142 −1.81 
    Kelch-like 2, Mayven (DrosophilaAI348818 KLHL2 GO:0006886 GO:0005515 0.0106 −2.05 
    γ-Aminobutyric acid A receptor R43452 GABRB3 GO:0006811 GO:0004890 0.0042 −2.36 
    Ras-GTPase–activating protein SH3 domain binding AA598628 G3BP GO:0006810 GO:0000166 0.0020 −3.82 
Chromatin modification       
    SET domain containing 1A AA459896 SETD1A GO:0016568 GO:0003723 0.016 1.87 
    Histone cluster 1, H2ac N50797 HIST1H2AC GO:0007001 GO:0003677 0.027 1.27 
Development-morphogenesis       
    Dopey family member 2 W15495 DOPEY2 GO:0007275 GO:0005554 0.012 2.57 
    DiGeorge syndrome critical region gene 14 AI369125 DGCR14 GO:0007399 GO:0005554 0.004 2.32 
    Fibroblast growth factor 11 AA936128 FGF11 GO:0007399 GO:0008083 0.004 2.26 
    Dishevelled, dsh homologue 2 (DrosophilaR38325 DVL2 GO:0007275 GO:0004871 0.007 2.07 
    Latent transforming growth factor β binding protein 4 R87406 LTBP4 GO:0007275 GO:0008083 0.007 1.99 
    Ephrin-B3 AA485665 EFNB3 GO:0030154 GO:0005005 0.000 1.64 
    Twist homologue 1 AI220198 TWIST1 GO:0009653 GO:0003677 0.003 −1.25 
    Bruno-like 4, RNA binding protein (DrosophilaR52541 BRUNOL4 GO:0009790 GO:0003676 0.0143 −1.34 
    Cysteine-rich transmembrane BMP regulator 1 R78638 CRIM1 GO:0007399 GO:0004867 0.012 −1.35 
    Protein inhibitor of activated STAT, 2 AI151206 PIAS2 GO:0007275 GO:0003677 0.001 −1.50 
    Hepatic leukemia factor R59192 HLF GO:0007275 GO:0003690 0.012 −1.50 
    Dual specificity phosphatase 22 AA454636 DUSP22 GO:0000188 GO:0008138 0.006 −1.64 
    Split hand/foot malformation (ectrodactyly) type 1 R38516 SHFM1 GO:0030326 GO:0005515 0.012 −1.72 
    Tropomyosin 3 AA206591 TPM3 GO:0007517 GO:0003779 0.002 −2.23 
    Microtubule-associated protein 1B H17493 MAP1B GO:0007517 GO:0005198 0.003 −2.64 
DNA repair and replication       
    Translin AA460927 TSN GO:0006310 GO:0003677 0.065 1.94 
    RAD51-like 3 (S. cerevisiaeN29765 RAD51L3 GO:0006284 GO:0005524 0.024 1.92 
    Nth endonuclease III-like 1 (E. coliAI369190 NTHL1 GO:0006284 GO:0003677 0.009 1.92 
    Ankyrin repeat domain 17 R37816 ANKRD17 GO:0006298 GO:0003676 0.055 1.78 
    Three prime repair exonuclease 1 AI352447 TREX1 GO:0006281 GO:0003697 0.011 1.54 
    Polymerase (DNA-directed) AI017254 POLD3 GO:0000731 GO:0003891 0.007 1.50 
    Excision repair cross-complementing rodent repair deficiency N49276 ERCC8 GO:0006281 GO:0003702 0.040 1.25 
    Ubiquitin-activating enzyme E1 AA598670 UBE1 GO:0006260 GO:0000166 0.044 −1.25 
    Structural maintenance of chromosomes 2 AA598549 SMC2 GO:0000067 GO:0000166 0.016 −1.61 
Miscellaneous processes       
    Diaphanous homologue 3 (DrosophilaAI018026 DIAPH3 GO:0016043 GO:0003779 0.004 2.22 
    Thrombospondin, type I, domain containing 4 AA120866 THSD4 GO:0031012 GO:0008233 0.009 1.85 
    Carcinoembryonic antigen-related cell adhesion AI242105 CEACAM4 GO:0005887 GO:0005554 0.010 1.65 
    Sarcospan (Kras oncogene-associated gene) AA458998 SSPN GO:0006936 GO:0005554 0.006 1.59 
    Annexin A5 AI269079 ANXA5 GO:0007596 GO:0004859 0.007 −1.39 
    Lactamase, β AI273225 LACTB GO:0046677 GO:0016787 0.002 −1.81 
RNA processing       
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 H82870 DDX17 GO:0006396 GO:0008026 0.003 3.02 
    Tetratricopeptide repeat domain 8 W37689 TTC8 GO:0007600 GO:0005488 0.016 1.87 
    Survival of motor neuron protein interacting protein 1 N26026 SIP1 GO:0000245 GO:0031202 0.017 1.74 
    Eukaryotic translation initiation factor 4A, isoform 3 N79030 EIF4A3 GO:0006364 GO:0005524 0.021 1.71 
    Processing of precursor 7 H71218 POP7 GO:0008033 GO:0003676 0.010 1.54 
    Pseudouridylate synthase 7 homologue (S. cerevisiaeAA434411 PUS7 GO:0008033 GO:0004730 0.017 1.44 
    BMS1-like, ribosome assembly protein (yeast) AA915891 BMS1L GO:0007046 GO:0000166 0.002 −1.69 
    Brix domain containing 2 AI025116 BXDC2 GO:0007046 GO:0005554 0.000 −2.10 
    Splicing factor, arginine/serine-rich 10 AI583623 SFRS10 GO:0000398 GO:0000166 0.002 −2.20 
Metabolism       
    Dihydrolipoamide branched chain transacylase E2 AI004719 DBT GO:0008152 GO:0005515 0.002 2.98 
    Homer homologue 1 (DrosophilaAA903860 HOMER1 GO:0007206 GO:0005515 0.005 2.02 
    Heparan sulfate (glucosamine) 3-O-sulfotransferase 4 AA973808 HS3ST4 GO:0030201 GO:0008467 0.046 1.98 
    Dehydrodolichyl diphosphate synthase AA995913 DHDDS GO:0008152 GO:0016740 0.009 1.96 
    Acyl-CoA synthetase short-chain family member 1 N67766 ACSS1 GO:0008152 GO:0003824 0.022 1.76 
    Fumarylacetoacetate hydrolase AA010559 FAH GO:0006559 GO:0000287 0.028 1.29 
    SID1 transmembrane family, member 2 T98941 SIDT2 GO:0016042 GO:0003847 0.018 1.27 
    Protein tyrosine phosphatase, receptor type, B N66422 PTPRB GO:0006796 GO:0005529 0.014 1.26 
    Acyl-CoA synthetase long-chain family member 3 AI206454 ACSL3 GO:000663 GO:0003824 0.012 −1.25 
    Amylase, α 1A; salivary R64129 AMY1A GO:0005975 GO:0004556 0.009 −125 
Protein biosynthesis and metabolism       
    Lysyl oxidase H80737 LOX GO:0006464 GO:0004720 0.002 3.67 
    Tubulin tyrosine ligase-like family, member 5 R34225 TTLL5 GO:0006464 GO:0004835 0.011 3.20 
    Vacuolar protein sorting 13 homologue C (S. cerevisiaeAA663968 VPS13C GO:0008104 GO:0005554 0.004 2.39 
    Protein tyrosine phosphatase, receptor type, C AA703526 PTPRC GO:0006470 GO:0004725 0.007 1.32 
    Ribosomal protein L9 AI199007 RPL9 GO:0006412 GO:0003723 0.011 1.26 
    GrpE-like 1, mitochondrial (E. coliAA449720 GRPEL1 GO:0006457 GO:0000774 0.011 1.25 
    Protein tyrosine phosphatase, nonreceptor type 21 W72293 PTPN21 GO:0006470 GO:0004725 0.028 1.25 
    β-site APP-cleaving enzyme 2 AA457119 BACE2 GO:0006464 GO:0004194 0.028 1.24 
    Hypothetical protein MGC42105 AA416627 MGC42105 GO:0006468 GO:0046872 0.022 1.24 
    Eukaryotic translation initiation factor 2B AI174400 EIF2B1 GO:0006412 GO:0003743 0.001 −1.45 
    Par-3 partitioning defective 3 homologue (C. elegansAA902790 PARD3 GO:0006461 GO:0005515 0.002 −1.55 
    Transient receptor potential cation channel AA598596 TRPC4AP GO:0006461 GO:0005524 0.007 −1.57 
    GrpE-like 2, mitochondrial (E. coliAA598831 GRPEL2 GO:0006457 GO:0000774 0.019 −1.61 
    Mitochondrial ribosomal protein S16 AA887401 MRPS16 GO:0006412 GO:0003735 0.001 −1.67 
    Collagen, type IV AA971606 COL4A3BP GO:0006468 GO:0004674 0.013 −1.67 
    Mitochondrial ribosomal protein S11 AI032875 MRPS11 GO:0006412 GO:0003735 0.013 −1.67 
    Farnesyltransferase, CAAX box, α AA283874 FNTA GO:0018347 GO:0004660 0.024 −1.72 
    Tryptophanyl tRNA synthetase 2 (mitochondrial) R43272 WARS2 GO:0006412 GO:0000166 0.017 −1.72 
    Capping protein (actin filament) muscle Z-line W92769 CAPZA1 GO:0006461 GO:0003779 0.004 −1.78 
    Lipase, hepatic AI054269 LIPC GO:0006487 GO:0004806 0.0028 −2.13 
    Eukaryotic translation initiation factor 1A AI214283 EIF1AY GO:0006412 GO:0003723 0.013 −2.15 
    Serine/threonine/tyrosine interacting-like 1 AI205036 STYXL1 GO:0006470 GO:0008138 0.0066 −2.69 
Proteolysis and ubiquitination       
    Cathepsin B AI091648 CTSB GO:0006508 GO:0004213 0.004 2.16 
    E3 ubiquitin protein ligase W86992 EDD1 GO:0006511 GO:0004840 0.016 1.66 
    Dipeptidyl-peptidase 3 AA430361 DPP3 GO:0006508 GO:0004177 0.007 1.54 
    Peptidase D AA481543 PEPD GO:0006508 GO:0004251 0.031 1.42 
    Ring finger protein 44 AI675516 RNF44 GO:0016567 GO:0004842 0.014 1.32 
    Gem (nuclear organelle) associated protein 4 AA041254 GEMIN4 GO:0000398 GO:0005515 0.028 1.30 
    Arginyltransferase 1 AI015417 ATE1 GO:0006512 GO:0004057 0.009 1.26 
    Heterogeneous nuclear ribonucleoprotein R AA779191 HNRPR GO:0006397 GO:0000166 0.013 1.25 
    SUMO-1 activating enzyme subunit 1 AA598486 SAE1 GO:0016567 GO:0004839 0.017 −1.58 
    Ubiquitin specific peptidase 30 AI055850 USP30 GO:0006511 GO:0004197 0.000 −1.77 
    TRIAD3 protein AI051657 TRIAD3 GO:0006512 GO:0008270 0.005 −2.04 
    Ubiquitin-conjugating enzyme E2E 1 AA197307 UBE2E1 GO:0006511 GO:0004840 0.013 −2.07 
    Ariadne homologue AI185068 ARIH1 GO:0006511 GO:0004842 0.003 −2.14 
    AFG3 ATPase family gene 3-like 2 (yeast) AI219905 AFG3L2 GO:0006508 GO:0000166 0.001 −2.18 
Transcription       
    Suppressor of Ty 5 homologue (S. cerevisiaeR21511 SUPT5H GO:0000122 GO:0003711 0.043 2.15 
    Inhibitor of DNA binding 4 AA464856 ID4 GO:0006357 GO:0003714 0.001 2.10 
    Bromodomain PHD finger transcription factor AA704421 BPTF GO:0000122 GO:0005515 0.066 2.00 
    Zinc finger protein 498 W94267 ZNF498 GO:0006355 GO:0003676 0.005 2.00 
    SRY (sex determining region Y)-box 10 AA976578 SOX10 GO:0006350 GO:0003677 0.028 1.93 
    Zinc finger protein 710 AI025842 ZNF710 GO:0006355 GO:0003676 0.005 1.90 
    General transcription factor IIB H23978 GTF2B GO:0006355 GO:0016251 0.009 1.54 
    Zinc finger protein 26 R97944 ZNF26 GO:0006355 GO:0003676 0.017 1.53 
    Zinc finger protein 268 AI277336 ZNF268 GO:0006355 GO:0008270 0.014 1.50 
    Protein inhibitor of activated STAT, 1 N91175 PIAS1 GO:0006350 GO:0003677 0.0280 1.31 
    Kv channel interacting protein 3, calsenilin H39123 KCNIP3 GO:0006350 GO:0003677 0.024 1.30 
    Zinc finger protein 275 AA406125 ZNF275 GO:0006355 GO:0003677 0.032 1.28 
    Homeobox D1 W68537 HOXD1 GO:0006355 GO:0003700 0.032 1.26 
    HIR histone cell cycle regulation defective homologue A AA609365 HIRA GO:0006357 GO:0003700 0.022 1.26 
    Forkhead box K2 AA136472 FOXK2 GO:0006350 GO:0003700 0.014 1.26 
    Transducin-like enhancer of split 3 (E(sp1) homologue) AI216623 TLE3 GO:0006355 GO:0005554 0.013 1.25 
    p300/CBP-associated factor N74637 PCAF GO:0006350 0.001368735 0.050 1.25 
    Zinc finger protein 544 AA885065 ZNF544 GO:0006355 GO:0003676 0.010 1.25 
    Regulatory factor X-associated protein AI365571 RFXAP GO:0006366 GO:0003700 0.013 1.24 
    Bromodomain adjacent to zinc finger domain, 2A AA699460 BAZ2A GO:0006355 GO:0003677 0.015 1.24 
    Zinc finger protein 16 H17016 ZNF16 GO:0006350 GO:0003677 0.012 1.23 
    Ring finger protein 12 AA598809 RNF12 GO:0006350 GO:0003714 0.007 −1.25 
    POU domain, class 6, transcription factor 1 AI123130 POU6F1 GO:0006355 GO:0003700 0.008 −1.37 
    RAR-related orphan receptor A AI022327 RORA GO:0006350 GO:0003700 0.011 −1.40 
    Myeloid/lymphoid or mixed-lineage leukemia AI197974 MLLT6 GO:0006355 GO:0005515 0.009 −1.41 
    Zinc finger protein 425 H20279 ZNF425 GO:0006355 GO:0003676 0.005 −1.62 
    PBX/knotted 1 homeobox 2 AI024125 PKNOX2 GO:0006355 GO:0003700 0.004 −1.64 
    D4, zinc and double PHD fingers family 2 AA496782 DPF2 GO:0006350 GO:0003676 0.016 −1.69 
    General transcription factor IIIC AI184450 GTF3C4 GO:0006350 GO:0003677 0.002 −1.87 
    GATA zinc finger domain containing 2A AA458840 GATAD2A GO:0006306 GO:0030674 0.022 −1.97 
    SRY (sex determining region Y)-box 3 AI359981 SOX3 GO:0006355 GO:0003677 0.004 −2.11 
    HDAC8 AI053481 HDAC8 GO:0000122 GO:0004407 0.002 −2.20 
    Methyl-CpG binding domain protein 3 AI017865 MBD3 GO:0006350 GO:0003677 0.002 −3.17 
Biological process unknown       
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 AI125363 DHX57 GO:0000004 GO:0003697 0.012 2.96 
    Frequenin homologue (DrosophilaAA918755 FREQ GO:0000004 GO:0005509 0.008 1.98 
    WD repeat domain 44 W80619 WDR44 GO:0000004 GO:0008270 0.016 1.86 
    Fibulin 2 AA452840 FBLN2 GO:0000004 GO:0005509 0.008 1.83 
    Ectonucleoside triphosphate diphosphohydrolase 3 AI247824 ENTPD3 GO:0000004 GO:0004050 0.023 1.26 
    Zinc finger, DHHC-type containing 9 AI346102 ZDHHC9 GO:0000004 GO:0000166 0.028 1.24 
    Docking protein 5 R39924 DOK5 GO:0000004 GO:0005158 0.026 −1.25 
    Progesterone receptor membrane component 2 AA456304 PGRMC2 GO:0000004 GO:0003707 0.011 −1.25 
    RB1-inducible coiled-coil 1 R38102 RB1CC1 GO:0000004 GO:0016301 0.026 −1.30 
    B-Cell CLL/lymphoma 7A H90147 BCL7A GO:0000004 GO:0003779 0.013 −1.30 
    Dedicator of cytokinesis 5 AA932511 DOCK5 GO:0000004 GO:0005085 0.004 −1.37 
    Zinc finger protein 320 AI025436 ZNF320 GO:0000004 GO:0003676 0.012 −1.50 
    Heterogeneous nuclear ribonucleoprotein M AI220112 HNRPM GO:0000004 GO:0003723 0.001 −1.73 
    Hypothetical protein MGC4562 AI184226 MGC4562 GO:0000004 GO:0003723 0.006 −1.85 
    Phosphatase and actin regulator 1 R99333 PHACTR1 GO:0000004 GO:0005096 0.005 −1.91 
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 AI003503 DDX46 GO:0000004 GO:0000166 0.0020 −2.19 
Biological process and molecular function unknown       
    ORM1-like 1 (S. cerevisiaeAA437132 ORMDL1 GO:0000004 GO:0005554 0.002 3.02 
    Ankyrin repeat domain 12 AA938440 ANKRD12 GO:0000004 GO:0005554 0.005 1.89 
    Transmembrane protein 27 AA999850 TMEM27 GO:0000004 GO:0005554 0.005 1.78 
    DKFZp434A0131 protein AA032084 DKFZP434A0131 GO:0000004 GO:0005554 0.028 1.25 
    Vitamin K epoxide reductase complex AI279477 VKORC1L1 GO:0000004 GO:0005554 0.010 −1.66 
    Zinc finger, RAN-binding domain containing 1 AI033098 ZRANB1 GO:0000004 GO:0005554 0.005 −1.85 
    Family with sequence similarity 57, member A H23091 FAM57A GO:0000004 GO:0005554 0.024 −3.86 
    Microcephaly, primary autosomal recessive 1 AA156424 MCPH1 GO:0000004 GO:0005554 0.010 −3.94 
    Transmembrane protein 32 AA251026 TMEM32 GO:0000004 GO:0005554 0.004 −4.43 
    Neurensin 2 AI199579 NRSN2 GO:0000004 GO:0005554 0.002 −4.85 
Gene nameGene IDSymbolGO no.Molecular function GO no.PadjustedFold increase/decrease
Apoptosis       
    BCL2-associated X protein AI565203 BAX GO:0006915 GO:0005515 0.023 2.65 
    CASP2 and RIPK1 AA285065 CRADD GO:0042981 GO:0005515 0.004 1.89 
    TNF receptor–associated factor 1 R71691 TRAF1 GO:0006915 GO:0006461 0.017 1.72 
    TIA1 cytotoxic granule-associated RNA binding protein R82978 TIA1 GO:0006915 GO:0000166 0.017 1.56 
    TNFRSF1A-associated via death domain AA916906 TRADD GO:0006915 GO:0005515 0.027 1.42 
    Protein phosphatase 1F AA806330 PPM1F GO:0006915 GO:0016787 0.014 1.35 
    Mdm4 AI310969 MDM4 GO:0006915 GO:0004842 0.013 −1.25 
    Programmed cell death AA416757 PDCD5 GO:0006915 GO:0005554 0.001 −2.15 
Antiapoptosis       
    Baculoviral inhibitor of apoptosis protein repeat–containing 6 H10434 BIRC6 GO:0006916 GO:0004840 0.013 −1.26 
    BCL2-associated athanogene 4 H22928 BAG4 GO:0006916 GO:0005057 0.026 −1.27 
Cell adhesion       
    Sema domain AA436152 SEMA5A GO:0007155 GO:0004872 0.050 1.81 
    Fibulin 5 H17615 FBLN5 GO:0007160 GO:0004888 0.010 1.79 
    Intercellular adhesion molecule 3 W95068 ICAM3 GO:0016337 GO:0005178 0.019 1.70 
    Formin binding protein 4 N49573 FNBP4 GO:0007155 GO:0005198 0.027 1.29 
    Sidekick homologue 1 (chicken) N23940 SDK1 GO:0007155 GO:0005515 0.026 1.26 
    Epithelial V-like antigen 1 AA668897 EVA1 GO:0007155 GO:0005515 0.011 1.25 
    Neuropilin 1 AA098867 NRP1 GO:0007155 GO:0004872 0.017 1.25 
    Discs, large homologue 5 (DrosophilaAA478949 DLG5 GO:0016337 GO:0005515 0.013 −1.80 
    Collagen, type XVI, α1 AA088202 COL16A1 GO:0007155 GO:0005198 0.010 −1.78 
    Down syndrome cell adhesion molecule N53145 DSCAM GO:0007155 GO:0005515 0.012 −2.10 
    Laminin, γ1 (formerly LAMB2) AA599005 LAMC1 GO:0007155 GO:0005515 0.001 −2.91 
Cell signaling-signal transduction       
    Egf-like module containing AI174266 EMR2 GO:0007165 GO:0004872 0.011 1.51 
    Low-density lipoprotein receptor–related protein 5 R83038 LRP5 GO:0016055 GO:0004872 0.014 1.40 
    G protein–coupled receptor kinase interactor 1 AI079118 GIT1 GO:0008277 GO:0005096 0.012 1.35 
    Insulin receptor substrate 1 AA456306 IRS1 GO:0007165 GO:0004871 0.022 1.29 
    Cornichon homologue 2 (DrosophilaR42919 CNIH2 GO:0007242 GO:0005554 0.010 1.25 
    Ankyrin 2, neuronal AI018106 ANK2 GO:0007165 GO:0005200 0.014 1.25 
    Galanin receptor 2 N75473 GALR2 GO:0007186 GO:0004966 0.030 1.20 
    Development and differentiation enhancing factor 2 AI054096 DDEF2 GO:0043087 GO:0005096 0.013 −1.30 
    BRCA2 and CDKN1A interacting protein AI033172 BCCIP GO:0000079 GO:0005554 0.007 −1.37 
    Rap guanine nucleotide exchange factor (GEF) 6 AA911005 RAPGEF6 GO:0007264 GO:0005085 0.002 −1.40 
    Endothelin receptor type A AA909960 EDNRA GO:0007186 GO:0001599 0.011 −1.45 
    Neuropeptide Y receptor Y1 R43817 NPY1R GO:0007165 GO:0001584 0.019 −1.46 
    Neuropeptide S receptor 1 H91700 NPSR1 GO:0007165 GO:0004872 0.014 −1.46 
    GIPC PDZ domain containing family, member 1 AI094796 GIPC1 GO:0007186 GO:0005515 0.011 −1.55 
    RAB27A, member RAS oncogene family AI309109 RAB27A GO:0007264 GO:0000166 0.005 −1.85 
    Ankyrin repeat and death domain containing 1A AI053438 ANKDD1A GO:0007165 GO:0005515| 0.009 −2.31 
Small inducible cytokine subfamily E H05323 SCYE1 GO:0007267 GO:0005125 0.002 −3.87 
    Coiled-coil domain containing 132 R49442 CCDC132 GO:0000160 GO:0000155 0.002 −3.89 
Cell cycle and growth       
    Homeodomain interacting protein kinase 2 N38891 HIPK2 GO:0000074 GO:0000166 0.007 1.87 
    Retinoblastoma binding protein 6 AA398302 RBBP6 GO:0000074 GO:0003676 0.012 1.58 
    DnaJ (Hsp40) homologue, subfamily A, member 2 AI273537 DNAJA2 GO:0000074 GO:0008270 0.002 1.56 
    Dynactin 1 (p150, glued homologue, DrosophilaAA488168 DCTN1 GO:0007067 GO:0003774 0.011 1.48 
    Transmembrane and coiled-coil domains 7 AI057241 TMCO7 GO:0007076 GO:0005488 0.011 −1.60 
    Sestrin 3 AI190194 SESN3 GO:0007050 GO:0005554 0.002 −1.90 
    LATS, large tumor suppressor, homologue 1 AI023733 LATS1 GO:0000086 GO:0000166 0.009 −1.98 
    Transforming, acidic coiled-coil containing protein 1 AA598796 TACC1 GO:0007049 GO:0005515 0.007 −2.17 
    Protein phosphatase 2 H09640 PPP2R1B GO:0000074 GO:0000158 0.019 −2.35 
    Katanin p60 subunit A 1 T47614 KATNA1 GO:0007049 GO:0000166 0.005 −2.66 
    G1 to S phase transition 1 R62452 GSPT1 GO:0000082 GO:0000166 0.000 −3.50 
Response to exogenous agents       
    Chromosome 10 open reading frame 59 AI093491 C10orf59 GO:0006725 GO:0004497 0.013 1.93 
    Thioredoxin reductase 1 AA464849 TXNRD1 GO:0045454 GO:0015036 0.006 1.92 
    Epoxide hydrolase 1, microsomal (xenobiotic) AA838691 EPHX1 GO:0006805 GO:0004301 0.012 1.78 
    Retinol dehydrogenase 11 (all-trans/9-cis/11-cisH82421 RDH11 GO:0008152 GO:0016491 0.016 1.64 
    N-Acetyltransferase 2 (arylamine N-acetyltransferase) AI460128 NAT2 GO:0008152 GO:0004060 0.009 1.50 
    Immunoglobulin (CD79A) binding protein 1 AA463498 IGBP1 GO:0042113 GO:0008601 0.005 1.38 
    Calcium binding atopy-related autoantigen 1 AA992324 CBARA1 GO:0006952 GO:0005509 0.013 1.38 
    Toll-interleukin 1 receptor AI279454 TIRAP GO:0006954 GO:0004888 0.009 1.38 
    Epoxide hydrolase 1, microsomal (xenobiotic) AA838691 EPHX1 GO:0006805 GO:0004301 0.012 1.25 
    Glutathione S-transferase 𝛉1 T64869 GSTT1 GO:0006950 GO:0004364 0.013 1.24 
Cell transport       
    Armadillo repeat containing 1 AA490502 ARMC1 GO:0030001 GO:0046872 0.0122 1.65 
    Solute carrier family 19, member 3 AA707858 SLC19A3 GO:0006810 GO:0005386 0.0232 1.64 
    Translocation protein 1 T98628 TLOC1 GO:0015031 GO:0004872 0.0120 1.63 
    SH3KBP1 binding protein 1 AA457723 SHKBP1 GO:0006813 GO:0005216 0.0232 1.63 
    Tweety homologue 1 (DrosophilaR56769 TTYH1 GO:0006826 GO:0005381 0.0232 1.60 
    Solute carrier family 22 AA705565 SLC22A9 GO:0006810 GO:0005215 0.0119 1.56 
    Translocated promoter region AA064778 TPR GO:0006810 GO:0005554 0.0069 1.53 
    UDP-N-acetyl-α-d-galactosamine AA598949 GALNT10 GO:0005794 GO:0003779 0.0071 1.47 
    HIV-1 Rev binding protein AA927604 HRB GO:0006406 GO:0003677 0.0124 1.40 
    Chloride channel 6 H72322 CLCN6 GO:0006811 GO:0005247 0.0220 1.35 
    Transient receptor potential cation channel AI167481 TRPM1 GO:0006812 GO:0005262 0.0144 1.24 
    Dysbindin domain containing 2 AA598970 DBNDD2 GO:0015031 GO:0005515 0.0247 −1.31 
    Frequenin homologue (DrosophilaH16821 FREQ GO:0005794 GO:0005509 0.0174 −1.42 
    Sorting nexin 11 H16467 SNX11 GO:0007242 GO:0005554 0.0247 −1.46 
    Acyl-CoA oxidase 1, palmitoyl AI079148 ACOX1 GO:0006118 GO:0003995 0.0101 −1.53 
    Ficolin (collagen/fibrinogen domain containing) 1 AI349250 FCN1 GO:0006817 GO:0003823 0.0084 −1.66 
    Cytochrome b5 reductase 4 AI053851 CYB5R4 GO:0006118 GO:0004128 0.0139 −1.70 
    Solute carrier family 20 (phosphate transporter) AA933776 SLC20A2 GO:0006810 GO:0004872 0.0108 −1.71 
    Stonin 2 AA992626 STON2 GO:0006886 GO:0005515 0.0056 −1.72 
    RAP1B, member of RAS oncogene family AA598864 RAP1B GO:0006886 GO:0005525 0.0142 −1.81 
    Kelch-like 2, Mayven (DrosophilaAI348818 KLHL2 GO:0006886 GO:0005515 0.0106 −2.05 
    γ-Aminobutyric acid A receptor R43452 GABRB3 GO:0006811 GO:0004890 0.0042 −2.36 
    Ras-GTPase–activating protein SH3 domain binding AA598628 G3BP GO:0006810 GO:0000166 0.0020 −3.82 
Chromatin modification       
    SET domain containing 1A AA459896 SETD1A GO:0016568 GO:0003723 0.016 1.87 
    Histone cluster 1, H2ac N50797 HIST1H2AC GO:0007001 GO:0003677 0.027 1.27 
Development-morphogenesis       
    Dopey family member 2 W15495 DOPEY2 GO:0007275 GO:0005554 0.012 2.57 
    DiGeorge syndrome critical region gene 14 AI369125 DGCR14 GO:0007399 GO:0005554 0.004 2.32 
    Fibroblast growth factor 11 AA936128 FGF11 GO:0007399 GO:0008083 0.004 2.26 
    Dishevelled, dsh homologue 2 (DrosophilaR38325 DVL2 GO:0007275 GO:0004871 0.007 2.07 
    Latent transforming growth factor β binding protein 4 R87406 LTBP4 GO:0007275 GO:0008083 0.007 1.99 
    Ephrin-B3 AA485665 EFNB3 GO:0030154 GO:0005005 0.000 1.64 
    Twist homologue 1 AI220198 TWIST1 GO:0009653 GO:0003677 0.003 −1.25 
    Bruno-like 4, RNA binding protein (DrosophilaR52541 BRUNOL4 GO:0009790 GO:0003676 0.0143 −1.34 
    Cysteine-rich transmembrane BMP regulator 1 R78638 CRIM1 GO:0007399 GO:0004867 0.012 −1.35 
    Protein inhibitor of activated STAT, 2 AI151206 PIAS2 GO:0007275 GO:0003677 0.001 −1.50 
    Hepatic leukemia factor R59192 HLF GO:0007275 GO:0003690 0.012 −1.50 
    Dual specificity phosphatase 22 AA454636 DUSP22 GO:0000188 GO:0008138 0.006 −1.64 
    Split hand/foot malformation (ectrodactyly) type 1 R38516 SHFM1 GO:0030326 GO:0005515 0.012 −1.72 
    Tropomyosin 3 AA206591 TPM3 GO:0007517 GO:0003779 0.002 −2.23 
    Microtubule-associated protein 1B H17493 MAP1B GO:0007517 GO:0005198 0.003 −2.64 
DNA repair and replication       
    Translin AA460927 TSN GO:0006310 GO:0003677 0.065 1.94 
    RAD51-like 3 (S. cerevisiaeN29765 RAD51L3 GO:0006284 GO:0005524 0.024 1.92 
    Nth endonuclease III-like 1 (E. coliAI369190 NTHL1 GO:0006284 GO:0003677 0.009 1.92 
    Ankyrin repeat domain 17 R37816 ANKRD17 GO:0006298 GO:0003676 0.055 1.78 
    Three prime repair exonuclease 1 AI352447 TREX1 GO:0006281 GO:0003697 0.011 1.54 
    Polymerase (DNA-directed) AI017254 POLD3 GO:0000731 GO:0003891 0.007 1.50 
    Excision repair cross-complementing rodent repair deficiency N49276 ERCC8 GO:0006281 GO:0003702 0.040 1.25 
    Ubiquitin-activating enzyme E1 AA598670 UBE1 GO:0006260 GO:0000166 0.044 −1.25 
    Structural maintenance of chromosomes 2 AA598549 SMC2 GO:0000067 GO:0000166 0.016 −1.61 
Miscellaneous processes       
    Diaphanous homologue 3 (DrosophilaAI018026 DIAPH3 GO:0016043 GO:0003779 0.004 2.22 
    Thrombospondin, type I, domain containing 4 AA120866 THSD4 GO:0031012 GO:0008233 0.009 1.85 
    Carcinoembryonic antigen-related cell adhesion AI242105 CEACAM4 GO:0005887 GO:0005554 0.010 1.65 
    Sarcospan (Kras oncogene-associated gene) AA458998 SSPN GO:0006936 GO:0005554 0.006 1.59 
    Annexin A5 AI269079 ANXA5 GO:0007596 GO:0004859 0.007 −1.39 
    Lactamase, β AI273225 LACTB GO:0046677 GO:0016787 0.002 −1.81 
RNA processing       
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 H82870 DDX17 GO:0006396 GO:0008026 0.003 3.02 
    Tetratricopeptide repeat domain 8 W37689 TTC8 GO:0007600 GO:0005488 0.016 1.87 
    Survival of motor neuron protein interacting protein 1 N26026 SIP1 GO:0000245 GO:0031202 0.017 1.74 
    Eukaryotic translation initiation factor 4A, isoform 3 N79030 EIF4A3 GO:0006364 GO:0005524 0.021 1.71 
    Processing of precursor 7 H71218 POP7 GO:0008033 GO:0003676 0.010 1.54 
    Pseudouridylate synthase 7 homologue (S. cerevisiaeAA434411 PUS7 GO:0008033 GO:0004730 0.017 1.44 
    BMS1-like, ribosome assembly protein (yeast) AA915891 BMS1L GO:0007046 GO:0000166 0.002 −1.69 
    Brix domain containing 2 AI025116 BXDC2 GO:0007046 GO:0005554 0.000 −2.10 
    Splicing factor, arginine/serine-rich 10 AI583623 SFRS10 GO:0000398 GO:0000166 0.002 −2.20 
Metabolism       
    Dihydrolipoamide branched chain transacylase E2 AI004719 DBT GO:0008152 GO:0005515 0.002 2.98 
    Homer homologue 1 (DrosophilaAA903860 HOMER1 GO:0007206 GO:0005515 0.005 2.02 
    Heparan sulfate (glucosamine) 3-O-sulfotransferase 4 AA973808 HS3ST4 GO:0030201 GO:0008467 0.046 1.98 
    Dehydrodolichyl diphosphate synthase AA995913 DHDDS GO:0008152 GO:0016740 0.009 1.96 
    Acyl-CoA synthetase short-chain family member 1 N67766 ACSS1 GO:0008152 GO:0003824 0.022 1.76 
    Fumarylacetoacetate hydrolase AA010559 FAH GO:0006559 GO:0000287 0.028 1.29 
    SID1 transmembrane family, member 2 T98941 SIDT2 GO:0016042 GO:0003847 0.018 1.27 
    Protein tyrosine phosphatase, receptor type, B N66422 PTPRB GO:0006796 GO:0005529 0.014 1.26 
    Acyl-CoA synthetase long-chain family member 3 AI206454 ACSL3 GO:000663 GO:0003824 0.012 −1.25 
    Amylase, α 1A; salivary R64129 AMY1A GO:0005975 GO:0004556 0.009 −125 
Protein biosynthesis and metabolism       
    Lysyl oxidase H80737 LOX GO:0006464 GO:0004720 0.002 3.67 
    Tubulin tyrosine ligase-like family, member 5 R34225 TTLL5 GO:0006464 GO:0004835 0.011 3.20 
    Vacuolar protein sorting 13 homologue C (S. cerevisiaeAA663968 VPS13C GO:0008104 GO:0005554 0.004 2.39 
    Protein tyrosine phosphatase, receptor type, C AA703526 PTPRC GO:0006470 GO:0004725 0.007 1.32 
    Ribosomal protein L9 AI199007 RPL9 GO:0006412 GO:0003723 0.011 1.26 
    GrpE-like 1, mitochondrial (E. coliAA449720 GRPEL1 GO:0006457 GO:0000774 0.011 1.25 
    Protein tyrosine phosphatase, nonreceptor type 21 W72293 PTPN21 GO:0006470 GO:0004725 0.028 1.25 
    β-site APP-cleaving enzyme 2 AA457119 BACE2 GO:0006464 GO:0004194 0.028 1.24 
    Hypothetical protein MGC42105 AA416627 MGC42105 GO:0006468 GO:0046872 0.022 1.24 
    Eukaryotic translation initiation factor 2B AI174400 EIF2B1 GO:0006412 GO:0003743 0.001 −1.45 
    Par-3 partitioning defective 3 homologue (C. elegansAA902790 PARD3 GO:0006461 GO:0005515 0.002 −1.55 
    Transient receptor potential cation channel AA598596 TRPC4AP GO:0006461 GO:0005524 0.007 −1.57 
    GrpE-like 2, mitochondrial (E. coliAA598831 GRPEL2 GO:0006457 GO:0000774 0.019 −1.61 
    Mitochondrial ribosomal protein S16 AA887401 MRPS16 GO:0006412 GO:0003735 0.001 −1.67 
    Collagen, type IV AA971606 COL4A3BP GO:0006468 GO:0004674 0.013 −1.67 
    Mitochondrial ribosomal protein S11 AI032875 MRPS11 GO:0006412 GO:0003735 0.013 −1.67 
    Farnesyltransferase, CAAX box, α AA283874 FNTA GO:0018347 GO:0004660 0.024 −1.72 
    Tryptophanyl tRNA synthetase 2 (mitochondrial) R43272 WARS2 GO:0006412 GO:0000166 0.017 −1.72 
    Capping protein (actin filament) muscle Z-line W92769 CAPZA1 GO:0006461 GO:0003779 0.004 −1.78 
    Lipase, hepatic AI054269 LIPC GO:0006487 GO:0004806 0.0028 −2.13 
    Eukaryotic translation initiation factor 1A AI214283 EIF1AY GO:0006412 GO:0003723 0.013 −2.15 
    Serine/threonine/tyrosine interacting-like 1 AI205036 STYXL1 GO:0006470 GO:0008138 0.0066 −2.69 
Proteolysis and ubiquitination       
    Cathepsin B AI091648 CTSB GO:0006508 GO:0004213 0.004 2.16 
    E3 ubiquitin protein ligase W86992 EDD1 GO:0006511 GO:0004840 0.016 1.66 
    Dipeptidyl-peptidase 3 AA430361 DPP3 GO:0006508 GO:0004177 0.007 1.54 
    Peptidase D AA481543 PEPD GO:0006508 GO:0004251 0.031 1.42 
    Ring finger protein 44 AI675516 RNF44 GO:0016567 GO:0004842 0.014 1.32 
    Gem (nuclear organelle) associated protein 4 AA041254 GEMIN4 GO:0000398 GO:0005515 0.028 1.30 
    Arginyltransferase 1 AI015417 ATE1 GO:0006512 GO:0004057 0.009 1.26 
    Heterogeneous nuclear ribonucleoprotein R AA779191 HNRPR GO:0006397 GO:0000166 0.013 1.25 
    SUMO-1 activating enzyme subunit 1 AA598486 SAE1 GO:0016567 GO:0004839 0.017 −1.58 
    Ubiquitin specific peptidase 30 AI055850 USP30 GO:0006511 GO:0004197 0.000 −1.77 
    TRIAD3 protein AI051657 TRIAD3 GO:0006512 GO:0008270 0.005 −2.04 
    Ubiquitin-conjugating enzyme E2E 1 AA197307 UBE2E1 GO:0006511 GO:0004840 0.013 −2.07 
    Ariadne homologue AI185068 ARIH1 GO:0006511 GO:0004842 0.003 −2.14 
    AFG3 ATPase family gene 3-like 2 (yeast) AI219905 AFG3L2 GO:0006508 GO:0000166 0.001 −2.18 
Transcription       
    Suppressor of Ty 5 homologue (S. cerevisiaeR21511 SUPT5H GO:0000122 GO:0003711 0.043 2.15 
    Inhibitor of DNA binding 4 AA464856 ID4 GO:0006357 GO:0003714 0.001 2.10 
    Bromodomain PHD finger transcription factor AA704421 BPTF GO:0000122 GO:0005515 0.066 2.00 
    Zinc finger protein 498 W94267 ZNF498 GO:0006355 GO:0003676 0.005 2.00 
    SRY (sex determining region Y)-box 10 AA976578 SOX10 GO:0006350 GO:0003677 0.028 1.93 
    Zinc finger protein 710 AI025842 ZNF710 GO:0006355 GO:0003676 0.005 1.90 
    General transcription factor IIB H23978 GTF2B GO:0006355 GO:0016251 0.009 1.54 
    Zinc finger protein 26 R97944 ZNF26 GO:0006355 GO:0003676 0.017 1.53 
    Zinc finger protein 268 AI277336 ZNF268 GO:0006355 GO:0008270 0.014 1.50 
    Protein inhibitor of activated STAT, 1 N91175 PIAS1 GO:0006350 GO:0003677 0.0280 1.31 
    Kv channel interacting protein 3, calsenilin H39123 KCNIP3 GO:0006350 GO:0003677 0.024 1.30 
    Zinc finger protein 275 AA406125 ZNF275 GO:0006355 GO:0003677 0.032 1.28 
    Homeobox D1 W68537 HOXD1 GO:0006355 GO:0003700 0.032 1.26 
    HIR histone cell cycle regulation defective homologue A AA609365 HIRA GO:0006357 GO:0003700 0.022 1.26 
    Forkhead box K2 AA136472 FOXK2 GO:0006350 GO:0003700 0.014 1.26 
    Transducin-like enhancer of split 3 (E(sp1) homologue) AI216623 TLE3 GO:0006355 GO:0005554 0.013 1.25 
    p300/CBP-associated factor N74637 PCAF GO:0006350 0.001368735 0.050 1.25 
    Zinc finger protein 544 AA885065 ZNF544 GO:0006355 GO:0003676 0.010 1.25 
    Regulatory factor X-associated protein AI365571 RFXAP GO:0006366 GO:0003700 0.013 1.24 
    Bromodomain adjacent to zinc finger domain, 2A AA699460 BAZ2A GO:0006355 GO:0003677 0.015 1.24 
    Zinc finger protein 16 H17016 ZNF16 GO:0006350 GO:0003677 0.012 1.23 
    Ring finger protein 12 AA598809 RNF12 GO:0006350 GO:0003714 0.007 −1.25 
    POU domain, class 6, transcription factor 1 AI123130 POU6F1 GO:0006355 GO:0003700 0.008 −1.37 
    RAR-related orphan receptor A AI022327 RORA GO:0006350 GO:0003700 0.011 −1.40 
    Myeloid/lymphoid or mixed-lineage leukemia AI197974 MLLT6 GO:0006355 GO:0005515 0.009 −1.41 
    Zinc finger protein 425 H20279 ZNF425 GO:0006355 GO:0003676 0.005 −1.62 
    PBX/knotted 1 homeobox 2 AI024125 PKNOX2 GO:0006355 GO:0003700 0.004 −1.64 
    D4, zinc and double PHD fingers family 2 AA496782 DPF2 GO:0006350 GO:0003676 0.016 −1.69 
    General transcription factor IIIC AI184450 GTF3C4 GO:0006350 GO:0003677 0.002 −1.87 
    GATA zinc finger domain containing 2A AA458840 GATAD2A GO:0006306 GO:0030674 0.022 −1.97 
    SRY (sex determining region Y)-box 3 AI359981 SOX3 GO:0006355 GO:0003677 0.004 −2.11 
    HDAC8 AI053481 HDAC8 GO:0000122 GO:0004407 0.002 −2.20 
    Methyl-CpG binding domain protein 3 AI017865 MBD3 GO:0006350 GO:0003677 0.002 −3.17 
Biological process unknown       
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 AI125363 DHX57 GO:0000004 GO:0003697 0.012 2.96 
    Frequenin homologue (DrosophilaAA918755 FREQ GO:0000004 GO:0005509 0.008 1.98 
    WD repeat domain 44 W80619 WDR44 GO:0000004 GO:0008270 0.016 1.86 
    Fibulin 2 AA452840 FBLN2 GO:0000004 GO:0005509 0.008 1.83 
    Ectonucleoside triphosphate diphosphohydrolase 3 AI247824 ENTPD3 GO:0000004 GO:0004050 0.023 1.26 
    Zinc finger, DHHC-type containing 9 AI346102 ZDHHC9 GO:0000004 GO:0000166 0.028 1.24 
    Docking protein 5 R39924 DOK5 GO:0000004 GO:0005158 0.026 −1.25 
    Progesterone receptor membrane component 2 AA456304 PGRMC2 GO:0000004 GO:0003707 0.011 −1.25 
    RB1-inducible coiled-coil 1 R38102 RB1CC1 GO:0000004 GO:0016301 0.026 −1.30 
    B-Cell CLL/lymphoma 7A H90147 BCL7A GO:0000004 GO:0003779 0.013 −1.30 
    Dedicator of cytokinesis 5 AA932511 DOCK5 GO:0000004 GO:0005085 0.004 −1.37 
    Zinc finger protein 320 AI025436 ZNF320 GO:0000004 GO:0003676 0.012 −1.50 
    Heterogeneous nuclear ribonucleoprotein M AI220112 HNRPM GO:0000004 GO:0003723 0.001 −1.73 
    Hypothetical protein MGC4562 AI184226 MGC4562 GO:0000004 GO:0003723 0.006 −1.85 
    Phosphatase and actin regulator 1 R99333 PHACTR1 GO:0000004 GO:0005096 0.005 −1.91 
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 AI003503 DDX46 GO:0000004 GO:0000166 0.0020 −2.19 
Biological process and molecular function unknown       
    ORM1-like 1 (S. cerevisiaeAA437132 ORMDL1 GO:0000004 GO:0005554 0.002 3.02 
    Ankyrin repeat domain 12 AA938440 ANKRD12 GO:0000004 GO:0005554 0.005 1.89 
    Transmembrane protein 27 AA999850 TMEM27 GO:0000004 GO:0005554 0.005 1.78 
    DKFZp434A0131 protein AA032084 DKFZP434A0131 GO:0000004 GO:0005554 0.028 1.25 
    Vitamin K epoxide reductase complex AI279477 VKORC1L1 GO:0000004 GO:0005554 0.010 −1.66 
    Zinc finger, RAN-binding domain containing 1 AI033098 ZRANB1 GO:0000004 GO:0005554 0.005 −1.85 
    Family with sequence similarity 57, member A H23091 FAM57A GO:0000004 GO:0005554 0.024 −3.86 
    Microcephaly, primary autosomal recessive 1 AA156424 MCPH1 GO:0000004 GO:0005554 0.010 −3.94 
    Transmembrane protein 32 AA251026 TMEM32 GO:0000004 GO:0005554 0.004 −4.43 
    Neurensin 2 AI199579 NRSN2 GO:0000004 GO:0005554 0.002 −4.85 

Abbreviations: CLL, chronic lymphocytic leukemia; ORM1, Homo sapiens orosomucoid 1; RAR, retinoic acid receptor; TNFRSF1A, TNF receptor superfamily, member 1A.

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