Profile of the four groups of patients and diagnosis of breast lesions from which normal Lob 1 epithelium was obtained by laser capture microdissection
. | Case ID . | Age at diagnosis (y) . | Age at first birth (y) . | Breast biopsy diagnosis . | Parity status . | RNA (ng)* . | aaRNA (ng) . | Ratio 260/280 . |
---|---|---|---|---|---|---|---|---|
1 | 81719 | 50 | 33 | Fibrocystic changes | Parous control | 28.90 | 997.80 | 1.99 |
2 | 84453 | 59 | 25 | Ductal hyperplasia | Parous control | 58.10 | 896.10 | 2.01 |
3 | 110857 | 55 | 22 | Fibroadenoma | Parous control | 54.60 | 938.20 | 2.02 |
4 | 119747 | 61 | 25 | Fibrocystic changes | Parous control | 25.90 | 961.10 | 2.04 |
5 | 131682 | 55 | 17 | Ductal hyperplasia, mild | Parous control | 25.80 | 725.10 | 1.99 |
6 | 134134 | 61 | 34 | Fibroadenoma, adenosis | Parous control | 80.90 | 6,072.00 | 2.00 |
7 | 135125 | 52 | 31 | Adenosis, ductal ectasia | Parous control | 224.70 | 1,483.30 | 2.03 |
8 | 135447 | 77 | 23 | Apocrine metaplasia | Parous control | 28.90 | 865.00 | 2.05 |
9 | 135990 | 64 | 27 | Adenosis | Parous control | 47.90 | 901.40 | 2.03 |
10 | 136383 | 71 | 24 | Adenosis | Parous control | 46.50 | 3,823.00 | 2.02 |
11 | 136880 | 59 | 20 | Papilloma | Parous control | 39.70 | 968.30 | 2.03 |
12 | 137340 | 63 | 18 | Ductal hyperplasia, mild | Parous control | 35.80 | 235.40 | 2.01 |
13 | 139641 | 61 | 21 | Stromal fibrosis | Parous control | 49.70 | 1,468.20 | 1.99 |
14 | 141007 | 77 | 21 | Adenosis | Parous control | 40.60 | 1,283.50 | 2.02 |
15 | 141300 | 78 | 24 | Adenosis | Parous control | 161.90 | 2,358.10 | 2.02 |
17 | 143793 | 72 | 27 | Adenosis | Parous control | 20.30 | 439.30 | 2.01 |
18 | 148115 | 60 | 20 | Benign breast disease | Parous control | 46.30 | 412.40 | 2.00 |
19 | 131453 | 71 | 17 | Invasive Ductal carcinoma | Parous case | 52.50 | 2,115.60 | 2.03 |
20 | 132370 | 61 | 26 | Invasive Ductal Carcinoma | Parous case | 20.10 | 65.00 | 2.05 |
21 | 132452 | 55 | 26 | Invasive Ductal and lobular carcinoma | Parous case | 51.10 | 1,225.80 | 2.07 |
22 | 132454 | 60 | 25 | Invasive ductal carcinoma | Parous case | 46.30 | 544.40 | 2.02 |
23 | 132456 | 72 | 19 | Invasive ductal carcinoma | Parous case | 100.50 | 53.20 | 2.03 |
24 | 133360 | 57 | 19 | Invasive ductal carcinoma | Parous case | 54.90 | 1,534.00 | 2.01 |
25 | 133931 | 74 | 26 | Invasive ductal and lobular carcinoma | Parous case | 22.20 | 1,682.90 | 2.00 |
26 | 134133 | 75 | 26 | Invasive ductal carcinoma | Parous case | 41.70 | 6,421.80 | 2.00 |
27 | 154855 | 75 | 25 | Invasive ductal carcinoma | Parous case | 32.50 | 5,432.00 | 2.00 |
28 | 135984 | 76 | 20 | Mucinous adenocarcinoma | Parous case | 21.90 | 1,443.80 | 2.00 |
29 | 137805 | 78 | 23 | Mucinous adenocarcinoma | Parous case | 401.40 | 1,235.00 | 2.02 |
30 | 138206 | 59 | 28 | Invasive Ductal carcinoma and DCIS | Parous case | 45.40 | 1,574.20 | 2.00 |
31 | 138993 | 76 | 26 | Invasive Ductal carcinoma | Parous case | 83.40 | 7,473.40 | 2.04 |
32 | 139128 | 84 | 31 | Invasive ductal carcinoma | Parous case | 79.30 | 1,310.20 | 2.00 |
33 | 140569 | 67 | 24 | Invasive ductal carcinoma | Parous case | 41.10 | 1,093.00 | 2.00 |
34 | 141008 | 55 | 29 | Invasive ductal carcinoma and DCIS | Parous case | 29.70 | 1,405.60 | 2.00 |
35 | 141299 | 75 | 27 | Invasive ductal carcinoma and DCIS | Parous case | 42.90 | 762.30 | 2.05 |
38 | 145563 | 65 | 23 | Invasive ductal carcinoma | Parous case | 17.90 | 764.00 | 2.00 |
39 | 145564 | 74 | 25 | Invasive ductal carcinoma | Parous case | 28.50 | 828.20 | 2.00 |
40 | 145565 | 62 | 28 | Invasive ductal carcinoma and DCIS | Parous case | 26.10 | 682.60 | 2.02 |
41 | 146980 | 65 | 26 | Invasive ductal carcinoma | Parous case | 17.10 | 411.60 | 2.02 |
42 | 147715 | 81 | 25 | Invasive ductal carcinoma and DCIS | Parous case | 106.30 | 416.70 | 2.02 |
43 | 149911 | 56 | 32 | Invasive ductal carcinoma and DCIS | Parous case | 107.30 | 1,425.76 | 2.02 |
44 | 153163 | 82 | 30 | Invasive lobular carcinoma | Parous case | 377.90 | 1,326.24 | 2.00 |
45 | 153556 | 65 | 30 | Invasive ductal carcinoma | Parous case | 309.10 | 1,427.00 | 2.00 |
46 | 154250 | 76 | 20 | Invasive ductal carcinoma and DCIS | Parous case | 310.10 | 1,428.24 | 2.11 |
47 | 155065 | 79 | 28 | Invasive ductal carcinoma | Parous case | 1,003.40 | 1,129.98 | 2.00 |
48 | 155844 | 75 | 26 | Invasive ductal carcinoma | Parous case | 1,537.70 | 1,430.24 | 2.06 |
49 | 155845 | 82 | 21 | Invasive ductal carcinoma | Parous case | 310.10 | 1,531.00 | 2.00 |
50 | 156062 | 58 | 26 | Invasive ductal carcinoma | Parous case | 311.10 | 1,432.24 | 2.08 |
51 | 156105 | 73 | 26 | Invasive lobular carcinoma and LCIS | Parous case | 305.80 | 1,233.24 | 2.00 |
52 | 157584 | 70 | 23 | Invasive lobular carcinoma | Parous case | 325.80 | 1,434.00 | 2.20 |
53 | 157678 | 92 | 19 | Invasive lobular Carcinoma | Parous case | 1,784.00 | 1,635.24 | 2.00 |
54 | 158532 | 70 | 25 | Invasive ductal carcinoma | Parous case | 1,655.80 | 1,146.94 | 2.00 |
55 | 158972 | 60 | 31 | Invasive ductal carcinoma and DCIS | Parous case | 966.90 | 1,437.50 | 2.01 |
56 | 158973 | 61 | 19 | Invasive ductal carcinoma | Parous case | 1,011.90 | 1,444.24 | 2.00 |
57 | 160038 | 60 | 16 | Invasive ductal carcinoma | Parous case | 429.80 | 1,439.24 | 2.00 |
58 | 160039 | 66 | 30 | Invasive ductal carcinoma and DCIS | Parous case | 1,783.50 | 1,440.00 | 2.01 |
59 | 160827 | 63 | 28 | Invasive ductal carcinoma and DCIS | Parous case | 355.70 | 1,441.24 | 2.00 |
60 | 15737 | 65 | N/A | Adenosis | Nulliparous control | 579.00 | 1,342.67 | 2.00 |
61 | 45853 | 62 | N/A | Fibroadenoma | Nulliparous control | 131.90 | 1,443.24 | 2.04 |
62 | 131161 | 58 | N/A | Papilloma | Nulliparous control | 51.10 | 2,005.80 | 2.00 |
63 | 132404 | 51 | N/A | Fibroadenoma, papilloma | Nulliparous control | 81.20 | 2,006.80 | 2.00 |
64 | 141009 | 53 | N/A | Stromal fibrosis | Nulliparous control | 108.80 | 977.40 | 2.07 |
65 | 143964 | 50 | N/A | Apocrine metaplasia, stromal fibrosis | Nulliparous control | 56.60 | 618.10 | 2.00 |
66 | 149204 | 58 | N/A | Adenosis | Nulliparous control | 31.10 | 401.60 | 2.00 |
67 | 132372 | 53 | N/A | Invasive ductal carcinoma | Nulliparous case | 20.90 | 557.50 | 2.05 |
68 | 132382 | 68 | N/A | Invasive ductal and lobular carcinoma | Nulliparous case | 27.60 | 386.60 | 2.00 |
69 | 132402 | 77 | N/A | Invasive ductal carcinoma | Nulliparous case | 776.70 | 387.60 | 2.00 |
70 | 136596 | 74 | N/A | Invasive ductal carcinoma | Nulliparous case | 51.70 | 891.60 | 1.99 |
71 | 142667 | 87 | N/A | Invasive ductal carcinoma | Nulliparous case | 37.10 | 1,217.50 | 2.00 |
72 | 144166 | 57 | N/A | Invasive ductal carcinoma | Nulliparous case | 646.70 | 1,218.50 | 2.00 |
73 | 155958 | 57 | N/A | Invasive lobular carcinoma | Nulliparous case | 150.50 | 1,219.50 | 2.08 |
74 | 156622 | 55 | N/A | Invasive ductal carcinoma | Nulliparous case | 433.60 | 1,220.50 | 2.00 |
. | Case ID . | Age at diagnosis (y) . | Age at first birth (y) . | Breast biopsy diagnosis . | Parity status . | RNA (ng)* . | aaRNA (ng) . | Ratio 260/280 . |
---|---|---|---|---|---|---|---|---|
1 | 81719 | 50 | 33 | Fibrocystic changes | Parous control | 28.90 | 997.80 | 1.99 |
2 | 84453 | 59 | 25 | Ductal hyperplasia | Parous control | 58.10 | 896.10 | 2.01 |
3 | 110857 | 55 | 22 | Fibroadenoma | Parous control | 54.60 | 938.20 | 2.02 |
4 | 119747 | 61 | 25 | Fibrocystic changes | Parous control | 25.90 | 961.10 | 2.04 |
5 | 131682 | 55 | 17 | Ductal hyperplasia, mild | Parous control | 25.80 | 725.10 | 1.99 |
6 | 134134 | 61 | 34 | Fibroadenoma, adenosis | Parous control | 80.90 | 6,072.00 | 2.00 |
7 | 135125 | 52 | 31 | Adenosis, ductal ectasia | Parous control | 224.70 | 1,483.30 | 2.03 |
8 | 135447 | 77 | 23 | Apocrine metaplasia | Parous control | 28.90 | 865.00 | 2.05 |
9 | 135990 | 64 | 27 | Adenosis | Parous control | 47.90 | 901.40 | 2.03 |
10 | 136383 | 71 | 24 | Adenosis | Parous control | 46.50 | 3,823.00 | 2.02 |
11 | 136880 | 59 | 20 | Papilloma | Parous control | 39.70 | 968.30 | 2.03 |
12 | 137340 | 63 | 18 | Ductal hyperplasia, mild | Parous control | 35.80 | 235.40 | 2.01 |
13 | 139641 | 61 | 21 | Stromal fibrosis | Parous control | 49.70 | 1,468.20 | 1.99 |
14 | 141007 | 77 | 21 | Adenosis | Parous control | 40.60 | 1,283.50 | 2.02 |
15 | 141300 | 78 | 24 | Adenosis | Parous control | 161.90 | 2,358.10 | 2.02 |
17 | 143793 | 72 | 27 | Adenosis | Parous control | 20.30 | 439.30 | 2.01 |
18 | 148115 | 60 | 20 | Benign breast disease | Parous control | 46.30 | 412.40 | 2.00 |
19 | 131453 | 71 | 17 | Invasive Ductal carcinoma | Parous case | 52.50 | 2,115.60 | 2.03 |
20 | 132370 | 61 | 26 | Invasive Ductal Carcinoma | Parous case | 20.10 | 65.00 | 2.05 |
21 | 132452 | 55 | 26 | Invasive Ductal and lobular carcinoma | Parous case | 51.10 | 1,225.80 | 2.07 |
22 | 132454 | 60 | 25 | Invasive ductal carcinoma | Parous case | 46.30 | 544.40 | 2.02 |
23 | 132456 | 72 | 19 | Invasive ductal carcinoma | Parous case | 100.50 | 53.20 | 2.03 |
24 | 133360 | 57 | 19 | Invasive ductal carcinoma | Parous case | 54.90 | 1,534.00 | 2.01 |
25 | 133931 | 74 | 26 | Invasive ductal and lobular carcinoma | Parous case | 22.20 | 1,682.90 | 2.00 |
26 | 134133 | 75 | 26 | Invasive ductal carcinoma | Parous case | 41.70 | 6,421.80 | 2.00 |
27 | 154855 | 75 | 25 | Invasive ductal carcinoma | Parous case | 32.50 | 5,432.00 | 2.00 |
28 | 135984 | 76 | 20 | Mucinous adenocarcinoma | Parous case | 21.90 | 1,443.80 | 2.00 |
29 | 137805 | 78 | 23 | Mucinous adenocarcinoma | Parous case | 401.40 | 1,235.00 | 2.02 |
30 | 138206 | 59 | 28 | Invasive Ductal carcinoma and DCIS | Parous case | 45.40 | 1,574.20 | 2.00 |
31 | 138993 | 76 | 26 | Invasive Ductal carcinoma | Parous case | 83.40 | 7,473.40 | 2.04 |
32 | 139128 | 84 | 31 | Invasive ductal carcinoma | Parous case | 79.30 | 1,310.20 | 2.00 |
33 | 140569 | 67 | 24 | Invasive ductal carcinoma | Parous case | 41.10 | 1,093.00 | 2.00 |
34 | 141008 | 55 | 29 | Invasive ductal carcinoma and DCIS | Parous case | 29.70 | 1,405.60 | 2.00 |
35 | 141299 | 75 | 27 | Invasive ductal carcinoma and DCIS | Parous case | 42.90 | 762.30 | 2.05 |
38 | 145563 | 65 | 23 | Invasive ductal carcinoma | Parous case | 17.90 | 764.00 | 2.00 |
39 | 145564 | 74 | 25 | Invasive ductal carcinoma | Parous case | 28.50 | 828.20 | 2.00 |
40 | 145565 | 62 | 28 | Invasive ductal carcinoma and DCIS | Parous case | 26.10 | 682.60 | 2.02 |
41 | 146980 | 65 | 26 | Invasive ductal carcinoma | Parous case | 17.10 | 411.60 | 2.02 |
42 | 147715 | 81 | 25 | Invasive ductal carcinoma and DCIS | Parous case | 106.30 | 416.70 | 2.02 |
43 | 149911 | 56 | 32 | Invasive ductal carcinoma and DCIS | Parous case | 107.30 | 1,425.76 | 2.02 |
44 | 153163 | 82 | 30 | Invasive lobular carcinoma | Parous case | 377.90 | 1,326.24 | 2.00 |
45 | 153556 | 65 | 30 | Invasive ductal carcinoma | Parous case | 309.10 | 1,427.00 | 2.00 |
46 | 154250 | 76 | 20 | Invasive ductal carcinoma and DCIS | Parous case | 310.10 | 1,428.24 | 2.11 |
47 | 155065 | 79 | 28 | Invasive ductal carcinoma | Parous case | 1,003.40 | 1,129.98 | 2.00 |
48 | 155844 | 75 | 26 | Invasive ductal carcinoma | Parous case | 1,537.70 | 1,430.24 | 2.06 |
49 | 155845 | 82 | 21 | Invasive ductal carcinoma | Parous case | 310.10 | 1,531.00 | 2.00 |
50 | 156062 | 58 | 26 | Invasive ductal carcinoma | Parous case | 311.10 | 1,432.24 | 2.08 |
51 | 156105 | 73 | 26 | Invasive lobular carcinoma and LCIS | Parous case | 305.80 | 1,233.24 | 2.00 |
52 | 157584 | 70 | 23 | Invasive lobular carcinoma | Parous case | 325.80 | 1,434.00 | 2.20 |
53 | 157678 | 92 | 19 | Invasive lobular Carcinoma | Parous case | 1,784.00 | 1,635.24 | 2.00 |
54 | 158532 | 70 | 25 | Invasive ductal carcinoma | Parous case | 1,655.80 | 1,146.94 | 2.00 |
55 | 158972 | 60 | 31 | Invasive ductal carcinoma and DCIS | Parous case | 966.90 | 1,437.50 | 2.01 |
56 | 158973 | 61 | 19 | Invasive ductal carcinoma | Parous case | 1,011.90 | 1,444.24 | 2.00 |
57 | 160038 | 60 | 16 | Invasive ductal carcinoma | Parous case | 429.80 | 1,439.24 | 2.00 |
58 | 160039 | 66 | 30 | Invasive ductal carcinoma and DCIS | Parous case | 1,783.50 | 1,440.00 | 2.01 |
59 | 160827 | 63 | 28 | Invasive ductal carcinoma and DCIS | Parous case | 355.70 | 1,441.24 | 2.00 |
60 | 15737 | 65 | N/A | Adenosis | Nulliparous control | 579.00 | 1,342.67 | 2.00 |
61 | 45853 | 62 | N/A | Fibroadenoma | Nulliparous control | 131.90 | 1,443.24 | 2.04 |
62 | 131161 | 58 | N/A | Papilloma | Nulliparous control | 51.10 | 2,005.80 | 2.00 |
63 | 132404 | 51 | N/A | Fibroadenoma, papilloma | Nulliparous control | 81.20 | 2,006.80 | 2.00 |
64 | 141009 | 53 | N/A | Stromal fibrosis | Nulliparous control | 108.80 | 977.40 | 2.07 |
65 | 143964 | 50 | N/A | Apocrine metaplasia, stromal fibrosis | Nulliparous control | 56.60 | 618.10 | 2.00 |
66 | 149204 | 58 | N/A | Adenosis | Nulliparous control | 31.10 | 401.60 | 2.00 |
67 | 132372 | 53 | N/A | Invasive ductal carcinoma | Nulliparous case | 20.90 | 557.50 | 2.05 |
68 | 132382 | 68 | N/A | Invasive ductal and lobular carcinoma | Nulliparous case | 27.60 | 386.60 | 2.00 |
69 | 132402 | 77 | N/A | Invasive ductal carcinoma | Nulliparous case | 776.70 | 387.60 | 2.00 |
70 | 136596 | 74 | N/A | Invasive ductal carcinoma | Nulliparous case | 51.70 | 891.60 | 1.99 |
71 | 142667 | 87 | N/A | Invasive ductal carcinoma | Nulliparous case | 37.10 | 1,217.50 | 2.00 |
72 | 144166 | 57 | N/A | Invasive ductal carcinoma | Nulliparous case | 646.70 | 1,218.50 | 2.00 |
73 | 155958 | 57 | N/A | Invasive lobular carcinoma | Nulliparous case | 150.50 | 1,219.50 | 2.08 |
74 | 156622 | 55 | N/A | Invasive ductal carcinoma | Nulliparous case | 433.60 | 1,220.50 | 2.00 |
NOTE: Groups of patients: parous controls, women with benign breast biopsies; parous cases, women with breast cancer; nulliparous controls, childless women with benign breast biopsies; and nulliparous cases, childless women with breast cancer.
Abbreviations: aaRNA, amplified RNA; DCIS, ductal carcinomas in situ; LCIS, lobular carcinoma in situ.
Total amount of RNA in nanograms obtained by laser capture microdissection from each sample.