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Table 2.

Prostate cancer incidence by use of cholesterol-lowering drugs, Cancer Prevention Study II Nutrition Cohort, 1997 to 2003

Never useFormer useCurrent use, <5 yCurrent use, ≥5 y
All prostate cancers     
    RR (95% CI) 1.00 (Reference) 0.88 (0.72-1.07) 1.02 (0.92-1.13) 1.06 (0.93-1.20) 
    Cases/person-years 2,350/193,971 114/10,925 559/47,009 390/32,147 
Stage II, low grade*     
    RR (95% CI) 1.00 (Reference) 0.79 (0.62-0.99) 1.03 (0.92-1.16) 1.13 (0.98-1.30) 
    Cases/person-years 1,825/193,971 79/10,925 441/47,009 321/32,147 
Stage II, high grade     
    RR (95% CI) 1.00 (Reference) 1.40 (0.85-2.31) 1.10 (0.81-1.5) 1.03 (0.70-1.51) 
    Cases/person-years 250/193,971 18/10,925 63/47,009 42/32,147 
Advanced prostate cancer     
    RR (95% CI) 1.00 (Reference) 1.05 (0.59-1.87) 0.92 (0.65-1.30) 0.60 (0.36-1.00) 
    Cases/person-years 239/193,971 13/10,925 46/47,009 19/32,147 
Never useFormer useCurrent use, <5 yCurrent use, ≥5 y
All prostate cancers     
    RR (95% CI) 1.00 (Reference) 0.88 (0.72-1.07) 1.02 (0.92-1.13) 1.06 (0.93-1.20) 
    Cases/person-years 2,350/193,971 114/10,925 559/47,009 390/32,147 
Stage II, low grade*     
    RR (95% CI) 1.00 (Reference) 0.79 (0.62-0.99) 1.03 (0.92-1.16) 1.13 (0.98-1.30) 
    Cases/person-years 1,825/193,971 79/10,925 441/47,009 321/32,147 
Stage II, high grade     
    RR (95% CI) 1.00 (Reference) 1.40 (0.85-2.31) 1.10 (0.81-1.5) 1.03 (0.70-1.51) 
    Cases/person-years 250/193,971 18/10,925 63/47,009 42/32,147 
Advanced prostate cancer     
    RR (95% CI) 1.00 (Reference) 1.05 (0.59-1.87) 0.92 (0.65-1.30) 0.60 (0.36-1.00) 
    Cases/person-years 239/193,971 13/10,925 46/47,009 19/32,147 

NOTE: Data were adjusted for age, race, education, BMI, NSAID use, history of PSA testing, elevated cholesterol, history of diabetes, history of heart attack, and family history of prostate cancer.

*

American Joint Committee on Cancer stage II (organ confined), and Gleason score of 7 or less.

American Joint Committee on Cancer stage II (organ confined), and Gleason score of 8 or more.

American Joint Committee on Cancer stage III or IV, or fatal prostate cancer of unknown stage at diagnosis.

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