Skip to Main Content
Table 2.

Adjusted RRs and 95% CIs of incident hematopoietic cancers and malignant gliomas according to aspartame intake levels derived from aspartame-containing beverages, the NIH-AARP Diet and Health Study, 1995-2000 (n = 473,984)

Aspartame intake (mg/d)All hematopoietic cancers
Gliomas*
Men and women combined
Men
Women
Men and women combined
Case, N = 1,888Person-yearsRR (95% CI)Case, N = 1,318Person-yearsRR (95% CI)Case, N = 570Person-yearsRR (95% CI)Case, N = 315RR (95% CI)
None 869 946,316 1.00 (Referent) 615 585,965 1.00 (Referent) 254 360,351 1.00 (Referent) 162 1.00 (Referent) 
>0, <100 432 505,228 0.91 (0.81-1.03) 294 279,047 0.95 (0.83-1.10) 138 226,181 0.83 (0.67-1.02) 83 0.99 (0.75-1.29) 
≥100, <200 280 274,430 1.10 (0.96-1.26) 187 158,731 1.09 (0.92-1.29) 93 115,699 1.11 (0.87-1.41) 32 0.70 (0.48-1.03) 
≥200, <400 137 148,017 1.01 (0.84-1.21) 95 86,800 1.03 (0.83-1.29) 42 61,217 0.95 (0.68-1.32) 16 0.66 (0.39-1.12) 
≥400, <600 104 109,262 1.05 (0.85-1.29) 76 70,059 1.07 (0.84-1.36) 28 39,204 1.02 (0.69-1.51) 22 0.73 (0.46-1.15) 
≥600 66 77,357 0.98 (0.76-1.27) 51 49,960 1.06 (0.79-1.42) 15 27,398 0.80 (0.47-1.35)   
P for trend   0.56   0.42   0.87  0.05 
Aspartame intake (mg/d)All hematopoietic cancers
Gliomas*
Men and women combined
Men
Women
Men and women combined
Case, N = 1,888Person-yearsRR (95% CI)Case, N = 1,318Person-yearsRR (95% CI)Case, N = 570Person-yearsRR (95% CI)Case, N = 315RR (95% CI)
None 869 946,316 1.00 (Referent) 615 585,965 1.00 (Referent) 254 360,351 1.00 (Referent) 162 1.00 (Referent) 
>0, <100 432 505,228 0.91 (0.81-1.03) 294 279,047 0.95 (0.83-1.10) 138 226,181 0.83 (0.67-1.02) 83 0.99 (0.75-1.29) 
≥100, <200 280 274,430 1.10 (0.96-1.26) 187 158,731 1.09 (0.92-1.29) 93 115,699 1.11 (0.87-1.41) 32 0.70 (0.48-1.03) 
≥200, <400 137 148,017 1.01 (0.84-1.21) 95 86,800 1.03 (0.83-1.29) 42 61,217 0.95 (0.68-1.32) 16 0.66 (0.39-1.12) 
≥400, <600 104 109,262 1.05 (0.85-1.29) 76 70,059 1.07 (0.84-1.36) 28 39,204 1.02 (0.69-1.51) 22 0.73 (0.46-1.15) 
≥600 66 77,357 0.98 (0.76-1.27) 51 49,960 1.06 (0.79-1.42) 15 27,398 0.80 (0.47-1.35)   
P for trend   0.56   0.42   0.87  0.05 

NOTE: Cox proportional hazards regression model adjusted for age at entry (continuous), sex (for combined analysis), ethnicity (non–Hispanic White, non–Hispanic Black, others), BMI (weight in kilograms/height in meters squared; 4 categories of ≥18.5 and <25, ≥25 and <30, ≥30 and <35, and ≥35), and history of diabetes.

*

Due to small numbers, aspartame categories of “≥400, <600” and “≥600” were collapsed for gliomas.

Close Modal

or Create an Account

Close Modal
Close Modal