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Table 1.

Summary of studies examining the frequency of second cancers in particular secondary NHL

AuthorsYearSource of dataPrimary cancerFollow-up periodTotal number of patientsNumbers of secondary cancersNumbers of sNHLPercentage of sNHL (%)Relative risk
Foss et al. (15) 2002 Norwegian cancer registry HL 1968-1985 1,024 197 31 24.2 (16.4-34.3) 
Travis et al. (16) 1997 Multinational cancer registries TC 1935-1993 28,843 1,406 68 0.23 1.88 (1.46-2.39) 
Tucker et al. (17) 1988 Stanford University Medical Center HL 1968-1985 1,507 98 0.59 0.5 (8.1-33.5) 
Kaldor et al. (18) 1987 Multinational population-based registries HL, TC, OC 1945-1984 133,411 3,157 97 0.07 1.8 (NA) 
Hooning et al. (19) 2005 Netherlands Cancer Institute BC 1970-2000 7,425 493 12 0.16 1.19 (0.61-2.08) 
Henry-Amar et al. (20) 1992 International database on Hodgkin disease HL 1960-1987 12,411 631 106 0.85 31.77 (NA) 
Van Leuwen et al. (21) 1994 Netherlands Cancer Institute HL 1966-1986 1,939 146 23 1.1 20.6 (13.1-30.9) 
Swerdlow et al. (22) 2000 BNLI and other United Kingdom databases* HL 1963-1993 5,519 322 50 0.90 14 (10.5-18.3) 
Mauch et al. (9) 1996 Hospital-based HL 1969-1988 794 72 10 1.25 18.4 (8.6-33.8) 
Neglia et al. (23) 2001 CCSSG Various 5-y follow-up 13,581 314 13 0.09 1.51 (0.80-2.58) 
Bhatia et al. (24) 1996 Multicenter cancer registries HL 1955-1986 1,380 79 0.43 20.9 (7.7-42.0) 
AuthorsYearSource of dataPrimary cancerFollow-up periodTotal number of patientsNumbers of secondary cancersNumbers of sNHLPercentage of sNHL (%)Relative risk
Foss et al. (15) 2002 Norwegian cancer registry HL 1968-1985 1,024 197 31 24.2 (16.4-34.3) 
Travis et al. (16) 1997 Multinational cancer registries TC 1935-1993 28,843 1,406 68 0.23 1.88 (1.46-2.39) 
Tucker et al. (17) 1988 Stanford University Medical Center HL 1968-1985 1,507 98 0.59 0.5 (8.1-33.5) 
Kaldor et al. (18) 1987 Multinational population-based registries HL, TC, OC 1945-1984 133,411 3,157 97 0.07 1.8 (NA) 
Hooning et al. (19) 2005 Netherlands Cancer Institute BC 1970-2000 7,425 493 12 0.16 1.19 (0.61-2.08) 
Henry-Amar et al. (20) 1992 International database on Hodgkin disease HL 1960-1987 12,411 631 106 0.85 31.77 (NA) 
Van Leuwen et al. (21) 1994 Netherlands Cancer Institute HL 1966-1986 1,939 146 23 1.1 20.6 (13.1-30.9) 
Swerdlow et al. (22) 2000 BNLI and other United Kingdom databases* HL 1963-1993 5,519 322 50 0.90 14 (10.5-18.3) 
Mauch et al. (9) 1996 Hospital-based HL 1969-1988 794 72 10 1.25 18.4 (8.6-33.8) 
Neglia et al. (23) 2001 CCSSG Various 5-y follow-up 13,581 314 13 0.09 1.51 (0.80-2.58) 
Bhatia et al. (24) 1996 Multicenter cancer registries HL 1955-1986 1,380 79 0.43 20.9 (7.7-42.0) 

Abbreviations: BNLI, British National Lymphoma Investigation; CCSSG, Childhood Cancer Survivor Study Group; HL, Hodgkin lymphoma; TC, testicular cancer; OC, ovarian cancer; BC, breast cancer; NA, data not available; sNHL, secondary NHL.

*

Royal Marsden Hospital and St. Bartholomew's Hospital.

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