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Table 2.

MEN syndromes and familial medullary thyroid cancer

CharacteristicsMEN 1MEN 2AMEN 2BFamilial medullary thyroid carcinoma
Chromosome 11q12-13 Pericentromeric 10 Pericentromeric 10 Pericentromeric 10 
Genetic defect MEN1 mutation RET mutation RET mutation RET mutation 
Medullary thyroid carcinoma No Bilateral Bilateral Bilateral 
Pheochromocytoma No 70% bilateral 70% bilateral No 
Parathyroid disease Hyperplasia Hyperplasia No No 
Pancreatic endocrine tumors Yes No No No 
CharacteristicsMEN 1MEN 2AMEN 2BFamilial medullary thyroid carcinoma
Chromosome 11q12-13 Pericentromeric 10 Pericentromeric 10 Pericentromeric 10 
Genetic defect MEN1 mutation RET mutation RET mutation RET mutation 
Medullary thyroid carcinoma No Bilateral Bilateral Bilateral 
Pheochromocytoma No 70% bilateral 70% bilateral No 
Parathyroid disease Hyperplasia Hyperplasia No No 
Pancreatic endocrine tumors Yes No No No 

NOTE: Reprinted with permission from Doherty and Jensen (3).

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