American Association for Cancer Research

Table 4.

Summary statistics (mean (⁠

\(\overline{\mathrm{ILCR}}_{1}^{i}\)

⁠) and SD) based on CSF set II by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

Toxicant	CASRN	CSF set II (mg/kg-d)⁻¹	R			Lt			Ult			PREP
Toxicant	CASRN	CSF set II (mg/kg-d)⁻¹				\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD
Acetaldehyde	75-07-0	0.01*	7e−05	8e−06	7e−05	8e−06	4e−05	1e−05	5e−06	5e−06
Acrylonitrile	107-13-1	1.0*	1e−04	3e−05	1e−04	3e−05	6e−05	3e−05	1e−05	1e−05
4-Aminobiphenyl	92-67-1	21*	5e−07	9e−08	4e−07	4e−08	2e−07	6e−08	2e−07	9e−08
Arsenic	7440-38-2	12*	8e−07	2e−07	6e−07	2e−07	3e−07	2e−07	2e−08	NA^†
Benzene	71-43-2	0.1*	4e−05	5e−06	3e−05	4e−06	2e−05	8e−06	4e−06	4e−06
Benzo[a]pyrene	50-32-8	3.9*	5e−07	8e−08	4e−07	5e−08	2e−07	6e−08	4e−08	5e−08
1,3-Butadiene	106-99-0	0.6*	2e−04	4e−05	2e−04	4e−05	1e−04	4e−05	3e−05	3e−05
Cadmium	7440-43-9	15*	1e−05	2e−06	8e−06	1e−06	4e−06	2e−06	6e−07	5e−07
Formaldehyde	50-00-0	0.021*	7e−06	1e−06	5e−06	2e−06	2e−06	1e−06	1e−06	1e−06
Lead	7439-92-1	0.042*	1e−08	2e−09	1e−08	2e−09	5e−09	2e−09	3e−09	1e−10
NNK^‡	64091-91-4	49^§	4e−05	5e−06	3e−05	5e−06	2e−05	6e−06	4e−06	7e−07
N-Nitrosonornicotine	80508-23-2	1.4*	2e−06	3e−07	1e−06	3e−07	8e−07	3e−07	1e−07	6e−08
Quinoline^‡	91-22-5	3^∥	2e−05	8e−06	1e−05	4e−06	7e−06	2e−06	2e−06	1e−06
Cancer risk subtotals
Human lung carcinogens^∥^,^¶ \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)					1e−04	3e−05	1e−04	3e−05	7e−05	3e−05	1e−05	1e−05
All cancers: \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub}\mathrm{{\Sigma}}}\)					5e−04	7e−05	5e−04	8e−05	3e−04	9e−05	4e−05	5e−05

Toxicant	CASRN	CSF set II (mg/kg-d)⁻¹	R			Lt			Ult			PREP
Toxicant	CASRN	CSF set II (mg/kg-d)⁻¹				\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD
Acetaldehyde	75-07-0	0.01*	7e−05	8e−06	7e−05	8e−06	4e−05	1e−05	5e−06	5e−06
Acrylonitrile	107-13-1	1.0*	1e−04	3e−05	1e−04	3e−05	6e−05	3e−05	1e−05	1e−05
4-Aminobiphenyl	92-67-1	21*	5e−07	9e−08	4e−07	4e−08	2e−07	6e−08	2e−07	9e−08
Arsenic	7440-38-2	12*	8e−07	2e−07	6e−07	2e−07	3e−07	2e−07	2e−08	NA^†
Benzene	71-43-2	0.1*	4e−05	5e−06	3e−05	4e−06	2e−05	8e−06	4e−06	4e−06
Benzo[a]pyrene	50-32-8	3.9*	5e−07	8e−08	4e−07	5e−08	2e−07	6e−08	4e−08	5e−08
1,3-Butadiene	106-99-0	0.6*	2e−04	4e−05	2e−04	4e−05	1e−04	4e−05	3e−05	3e−05
Cadmium	7440-43-9	15*	1e−05	2e−06	8e−06	1e−06	4e−06	2e−06	6e−07	5e−07
Formaldehyde	50-00-0	0.021*	7e−06	1e−06	5e−06	2e−06	2e−06	1e−06	1e−06	1e−06
Lead	7439-92-1	0.042*	1e−08	2e−09	1e−08	2e−09	5e−09	2e−09	3e−09	1e−10
NNK^‡	64091-91-4	49^§	4e−05	5e−06	3e−05	5e−06	2e−05	6e−06	4e−06	7e−07
N-Nitrosonornicotine	80508-23-2	1.4*	2e−06	3e−07	1e−06	3e−07	8e−07	3e−07	1e−07	6e−08
Quinoline^‡	91-22-5	3^∥	2e−05	8e−06	1e−05	4e−06	7e−06	2e−06	2e−06	1e−06
Cancer risk subtotals
Human lung carcinogens^∥^,^¶ \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)					1e−04	3e−05	1e−04	3e−05	7e−05	3e−05	1e−05	1e−05
All cancers: \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub}\mathrm{{\Sigma}}}\)					5e−04	7e−05	5e−04	8e−05	3e−04	9e−05	4e−05	5e−05

NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

†

NA = not available: limited PREP yield data did not allow calculations for some chemicals. Each mean corresponds to a different number of PREPs because each PREP study measured different chemicals.

‡

CSF was determined from an oral exposure study.

CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

∥

Integrated Risk Information System, U.S. Environmental Protection Agency (44).

\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)

= sum of

\(\overline{\mathrm{ILCR}}^{\mathit{i}}_{1}\)

for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.

View Large

This Feature Is Available To Subscribers Only