Skip to Main Content
Table 4.

Summary statistics (mean (

\(\overline{\mathrm{ILCR}}_{1}^{i}\)
⁠) and SD) based on CSF set II by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

ToxicantCASRNCSF set II (mg/kg-d)−1R
Lt
Ult
PREP
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
Acetaldehyde 75-07-0 0.01* 7e−05 8e−06 7e−05 8e−06 4e−05 1e−05 5e−06 5e−06 
Acrylonitrile 107-13-1 1.0* 1e−04 3e−05 1e−04 3e−05 6e−05 3e−05 1e−05 1e−05 
4-Aminobiphenyl 92-67-1 21* 5e−07 9e−08 4e−07 4e−08 2e−07 6e−08 2e−07 9e−08 
Arsenic 7440-38-2 12* 8e−07 2e−07 6e−07 2e−07 3e−07 2e−07 2e−08 NA 
Benzene 71-43-2 0.1* 4e−05 5e−06 3e−05 4e−06 2e−05 8e−06 4e−06 4e−06 
Benzo[a]pyrene 50-32-8 3.9* 5e−07 8e−08 4e−07 5e−08 2e−07 6e−08 4e−08 5e−08 
1,3-Butadiene 106-99-0 0.6* 2e−04 4e−05 2e−04 4e−05 1e−04 4e−05 3e−05 3e−05 
Cadmium 7440-43-9 15* 1e−05 2e−06 8e−06 1e−06 4e−06 2e−06 6e−07 5e−07 
Formaldehyde 50-00-0 0.021* 7e−06 1e−06 5e−06 2e−06 2e−06 1e−06 1e−06 1e−06 
Lead 7439-92-1 0.042* 1e−08 2e−09 1e−08 2e−09 5e−09 2e−09 3e−09 1e−10 
NNK 64091-91-4 49§ 4e−05 5e−06 3e−05 5e−06 2e−05 6e−06 4e−06 7e−07 
N-Nitrosonornicotine 80508-23-2 1.4* 2e−06 3e−07 1e−06 3e−07 8e−07 3e−07 1e−07 6e−08 
Quinoline 91-22-5 3 2e−05 8e−06 1e−05 4e−06 7e−06 2e−06 2e−06 1e−06 
Cancer risk subtotals           
    Human lung carcinogens,
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)
 
  1e−04 3e−05 1e−04 3e−05 7e−05 3e−05 1e−05 1e−05 
    All cancers:
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub}\mathrm{{\Sigma}}}\)
 
  5e−04 7e−05 5e−04 8e−05 3e−04 9e−05 4e−05 5e−05 
ToxicantCASRNCSF set II (mg/kg-d)−1R
Lt
Ult
PREP
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
Acetaldehyde 75-07-0 0.01* 7e−05 8e−06 7e−05 8e−06 4e−05 1e−05 5e−06 5e−06 
Acrylonitrile 107-13-1 1.0* 1e−04 3e−05 1e−04 3e−05 6e−05 3e−05 1e−05 1e−05 
4-Aminobiphenyl 92-67-1 21* 5e−07 9e−08 4e−07 4e−08 2e−07 6e−08 2e−07 9e−08 
Arsenic 7440-38-2 12* 8e−07 2e−07 6e−07 2e−07 3e−07 2e−07 2e−08 NA 
Benzene 71-43-2 0.1* 4e−05 5e−06 3e−05 4e−06 2e−05 8e−06 4e−06 4e−06 
Benzo[a]pyrene 50-32-8 3.9* 5e−07 8e−08 4e−07 5e−08 2e−07 6e−08 4e−08 5e−08 
1,3-Butadiene 106-99-0 0.6* 2e−04 4e−05 2e−04 4e−05 1e−04 4e−05 3e−05 3e−05 
Cadmium 7440-43-9 15* 1e−05 2e−06 8e−06 1e−06 4e−06 2e−06 6e−07 5e−07 
Formaldehyde 50-00-0 0.021* 7e−06 1e−06 5e−06 2e−06 2e−06 1e−06 1e−06 1e−06 
Lead 7439-92-1 0.042* 1e−08 2e−09 1e−08 2e−09 5e−09 2e−09 3e−09 1e−10 
NNK 64091-91-4 49§ 4e−05 5e−06 3e−05 5e−06 2e−05 6e−06 4e−06 7e−07 
N-Nitrosonornicotine 80508-23-2 1.4* 2e−06 3e−07 1e−06 3e−07 8e−07 3e−07 1e−07 6e−08 
Quinoline 91-22-5 3 2e−05 8e−06 1e−05 4e−06 7e−06 2e−06 2e−06 1e−06 
Cancer risk subtotals           
    Human lung carcinogens,
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)
 
  1e−04 3e−05 1e−04 3e−05 7e−05 3e−05 1e−05 1e−05 
    All cancers:
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub}\mathrm{{\Sigma}}}\)
 
  5e−04 7e−05 5e−04 8e−05 3e−04 9e−05 4e−05 5e−05 

NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

*

Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

NA = not available: limited PREP yield data did not allow calculations for some chemicals. Each mean corresponds to a different number of PREPs because each PREP study measured different chemicals.

CSF was determined from an oral exposure study.

§

CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

Integrated Risk Information System, U.S. Environmental Protection Agency (44).

\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}\mathrm{{-}lung}}\)
= sum of
\(\overline{\mathrm{ILCR}}^{\mathit{i}}_{1}\)
for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.

Close Modal

or Create an Account

Close Modal
Close Modal