American Association for Cancer Research

Table 3.

Summary statistics [mean (⁠

\(\overline{\mathrm{ILCR}}^{i}_{1}\)

⁠) and SD] based on CSF set I by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

Toxicant	CASRN	CSF set I (mg/kg-d)⁻¹	R			Lt			ULt			PREP
Toxicant	CASRN	CSF set I (mg/kg-d)⁻¹				\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD
Acetaldehyde	75-07-0	0.0077*	6e−05	6e−06	5e−05	6e−06	3e−05	1e−05	4e−06	4e−06
Acrylonitrile	107-13-1	0.24*	3e−05	6e−06	3e−05	8e−06	2e−05	7e−06	4e−06	3e−06
4-Aminobiphenyl	92-67-1	21^†	5e−07	9e−08	4e−07	4e−08	2e−07	6e−08	2e−07	9e−08
Arsenic	7440-38-2	15*	9e−07	3e−07	7e−07	2e−07	4e−07	2e−07	2e−08	NA^‡
Benzene	71-43-2	0.027*	9e−06	1e−06	9e−06	1e−06	6e−06	2e−06	1e−06	1e−06
Benzo[a]pyrene	50-32-8	3.9^†	5e−07	8e−08	4e−07	5e−08	2e−07	6e−08	4e−08	5e−08
1,3-Butadiene	106-99-0	0.11*	4e−05	7e−06	4e−05	8e−06	2e−05	8e−06	5e−06	5e−06
Cadmium	7440-43-9	6.3*	5e−06	7e−07	3e−06	6e−07	2e−06	7e−07	3e−07	2e−07
Formaldehyde	50-00-0	0.046*	2e−05	3e−06	1e−05	4e−06	5e−06	2e−06	2e−06	2e−06
Lead	7439-92-1	0.042^†	1e−08	2e−09	1e−08	2e−09	5e−09	2e−09	3e−09	1e−10
NNK^§	64091-91-4	49^∥	4e−05	5e−06	3e−05	5e−06	2e−05	6e−06	4e−06	7e−07
N-Nitrosonornicotine	80508-23-2	1.4^†	2e−06	3e−07	1e−06	3e−07	8e−07	3e−07	1e−07	6e−08
Quinoline^§	91-22-5	3*	2e−05	8e−06	1e−05	4e−06	7e−06	2e−06	2e−06	1e−06
Cancer risk subtotals
Human lung carcinogens*^,^¶ \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)					5e−05	1e−05	4e−05	1e−05	2e−05	9e−06	4e−06	5e−06
All cancers: \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}}\)					2e−04	2e−05	2e−04	3e−05	1e−04	3e−05	2e−05	2e−05

Toxicant	CASRN	CSF set I (mg/kg-d)⁻¹	R			Lt			ULt			PREP
Toxicant	CASRN	CSF set I (mg/kg-d)⁻¹				\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD	\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)	SD
Acetaldehyde	75-07-0	0.0077*	6e−05	6e−06	5e−05	6e−06	3e−05	1e−05	4e−06	4e−06
Acrylonitrile	107-13-1	0.24*	3e−05	6e−06	3e−05	8e−06	2e−05	7e−06	4e−06	3e−06
4-Aminobiphenyl	92-67-1	21^†	5e−07	9e−08	4e−07	4e−08	2e−07	6e−08	2e−07	9e−08
Arsenic	7440-38-2	15*	9e−07	3e−07	7e−07	2e−07	4e−07	2e−07	2e−08	NA^‡
Benzene	71-43-2	0.027*	9e−06	1e−06	9e−06	1e−06	6e−06	2e−06	1e−06	1e−06
Benzo[a]pyrene	50-32-8	3.9^†	5e−07	8e−08	4e−07	5e−08	2e−07	6e−08	4e−08	5e−08
1,3-Butadiene	106-99-0	0.11*	4e−05	7e−06	4e−05	8e−06	2e−05	8e−06	5e−06	5e−06
Cadmium	7440-43-9	6.3*	5e−06	7e−07	3e−06	6e−07	2e−06	7e−07	3e−07	2e−07
Formaldehyde	50-00-0	0.046*	2e−05	3e−06	1e−05	4e−06	5e−06	2e−06	2e−06	2e−06
Lead	7439-92-1	0.042^†	1e−08	2e−09	1e−08	2e−09	5e−09	2e−09	3e−09	1e−10
NNK^§	64091-91-4	49^∥	4e−05	5e−06	3e−05	5e−06	2e−05	6e−06	4e−06	7e−07
N-Nitrosonornicotine	80508-23-2	1.4^†	2e−06	3e−07	1e−06	3e−07	8e−07	3e−07	1e−07	6e−08
Quinoline^§	91-22-5	3*	2e−05	8e−06	1e−05	4e−06	7e−06	2e−06	2e−06	1e−06
Cancer risk subtotals
Human lung carcinogens*^,^¶ \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)					5e−05	1e−05	4e−05	1e−05	2e−05	9e−06	4e−06	5e−06
All cancers: \(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}}\)					2e−04	2e−05	2e−04	3e−05	1e−04	3e−05	2e−05	2e−05

NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

Abbreviation: CASRN, Chemical Abstracts Registry Number.

Integrated Risk Information System, U.S. Environmental Protection Agency (44).

†

Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

‡

NA, not available; limited PREP yield data did not allow calculations for some chemicals. The mean (⁠

\(\overline{\mathrm{ILCR}}^{i}_{1}\)

⁠) for each chemical corresponds to a different number of PREPs because each PREP study measured different chemicals.

CSF was determined from an oral exposure study.

∥

CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)

= sum of

\(\overline{\mathrm{ILCR}}^{i}_{1}\)

for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.

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