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Table 3.

Summary statistics [mean (

\(\overline{\mathrm{ILCR}}^{i}_{1}\)
⁠) and SD] based on CSF set I by cigarette type for ILCR values for 13 carcinogens for z = 1 pack-year

ToxicantCASRNCSF set I (mg/kg-d)−1R
Lt
ULt
PREP
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
Acetaldehyde 75-07-0 0.0077* 6e−05 6e−06 5e−05 6e−06 3e−05 1e−05 4e−06 4e−06 
Acrylonitrile 107-13-1 0.24* 3e−05 6e−06 3e−05 8e−06 2e−05 7e−06 4e−06 3e−06 
4-Aminobiphenyl 92-67-1 21 5e−07 9e−08 4e−07 4e−08 2e−07 6e−08 2e−07 9e−08 
Arsenic 7440-38-2 15* 9e−07 3e−07 7e−07 2e−07 4e−07 2e−07 2e−08 NA 
Benzene 71-43-2 0.027* 9e−06 1e−06 9e−06 1e−06 6e−06 2e−06 1e−06 1e−06 
Benzo[a]pyrene 50-32-8 3.9 5e−07 8e−08 4e−07 5e−08 2e−07 6e−08 4e−08 5e−08 
1,3-Butadiene 106-99-0 0.11* 4e−05 7e−06 4e−05 8e−06 2e−05 8e−06 5e−06 5e−06 
Cadmium 7440-43-9 6.3* 5e−06 7e−07 3e−06 6e−07 2e−06 7e−07 3e−07 2e−07 
Formaldehyde 50-00-0 0.046* 2e−05 3e−06 1e−05 4e−06 5e−06 2e−06 2e−06 2e−06 
Lead 7439-92-1 0.042 1e−08 2e−09 1e−08 2e−09 5e−09 2e−09 3e−09 1e−10 
NNK§ 64091-91-4 49 4e−05 5e−06 3e−05 5e−06 2e−05 6e−06 4e−06 7e−07 
N-Nitrosonornicotine 80508-23-2 1.4 2e−06 3e−07 1e−06 3e−07 8e−07 3e−07 1e−07 6e−08 
Quinoline§ 91-22-5 3* 2e−05 8e−06 1e−05 4e−06 7e−06 2e−06 2e−06 1e−06 
Cancer risk subtotals           
    Human lung carcinogens*,
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)
 
  5e−05 1e−05 4e−05 1e−05 2e−05 9e−06 4e−06 5e−06 
    All cancers:
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}}\)
 
  2e−04 2e−05 2e−04 3e−05 1e−04 3e−05 2e−05 2e−05 
ToxicantCASRNCSF set I (mg/kg-d)−1R
Lt
ULt
PREP
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
\(\overline{\mathrm{ILCR}}_{1}^{\mathit{i}}\)
SD
Acetaldehyde 75-07-0 0.0077* 6e−05 6e−06 5e−05 6e−06 3e−05 1e−05 4e−06 4e−06 
Acrylonitrile 107-13-1 0.24* 3e−05 6e−06 3e−05 8e−06 2e−05 7e−06 4e−06 3e−06 
4-Aminobiphenyl 92-67-1 21 5e−07 9e−08 4e−07 4e−08 2e−07 6e−08 2e−07 9e−08 
Arsenic 7440-38-2 15* 9e−07 3e−07 7e−07 2e−07 4e−07 2e−07 2e−08 NA 
Benzene 71-43-2 0.027* 9e−06 1e−06 9e−06 1e−06 6e−06 2e−06 1e−06 1e−06 
Benzo[a]pyrene 50-32-8 3.9 5e−07 8e−08 4e−07 5e−08 2e−07 6e−08 4e−08 5e−08 
1,3-Butadiene 106-99-0 0.11* 4e−05 7e−06 4e−05 8e−06 2e−05 8e−06 5e−06 5e−06 
Cadmium 7440-43-9 6.3* 5e−06 7e−07 3e−06 6e−07 2e−06 7e−07 3e−07 2e−07 
Formaldehyde 50-00-0 0.046* 2e−05 3e−06 1e−05 4e−06 5e−06 2e−06 2e−06 2e−06 
Lead 7439-92-1 0.042 1e−08 2e−09 1e−08 2e−09 5e−09 2e−09 3e−09 1e−10 
NNK§ 64091-91-4 49 4e−05 5e−06 3e−05 5e−06 2e−05 6e−06 4e−06 7e−07 
N-Nitrosonornicotine 80508-23-2 1.4 2e−06 3e−07 1e−06 3e−07 8e−07 3e−07 1e−07 6e−08 
Quinoline§ 91-22-5 3* 2e−05 8e−06 1e−05 4e−06 7e−06 2e−06 2e−06 1e−06 
Cancer risk subtotals           
    Human lung carcinogens*,
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)
 
  5e−05 1e−05 4e−05 1e−05 2e−05 9e−06 4e−06 5e−06 
    All cancers:
\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}}}\)
 
  2e−04 2e−05 2e−04 3e−05 1e−04 3e−05 2e−05 2e−05 

NOTE: Conventional cigarettes classified by FTC tar yield as follows (30): regular, tar ≥ 15.0 mg; light, 6.0 mg ≤ tar < 15.0 mg; and ultralight, 1.0 ≤ tar < 6.0 mg. PREP cigarettes not characterized by tar content.

Abbreviation: CASRN, Chemical Abstracts Registry Number.

*

Integrated Risk Information System, U.S. Environmental Protection Agency (44).

Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Sept. 2004 Cancer Potency List (46).

NA, not available; limited PREP yield data did not allow calculations for some chemicals. The mean (

\(\overline{\mathrm{ILCR}}^{i}_{1}\)
⁠) for each chemical corresponds to a different number of PREPs because each PREP study measured different chemicals.

§

CSF was determined from an oral exposure study.

CSF, 49 for all cancer end points. California Environmental Protection Agency. Sept. 2001 Expedited Cancer Potency Values and No Significant Risk Levels for Six Proposition 65 Carcinogens (47).

\(\overline{\mathrm{ILCR}}_{1}^{\mathrm{sub{\Sigma}{-}lung}}\)
= sum of
\(\overline{\mathrm{ILCR}}^{i}_{1}\)
for known human lung carcinogens considered here: acrylonitrile, arsenic, cadmium, and formaldehyde.

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