Observations on smoking-related disease and risk assessment calculations
| (a) Cigarette smoking causes considerable human disease, including many cases of lung cancer. |
| (b) Risk assessment methods use toxicant-by-toxicant exposure estimates to predict estimates of the incidence of cancer in humans. |
| (c) Cigarette yield data are available that give the per cigarette deliveries of some toxicants of interest in cigarette smoke. |
| (d) Risk assessment predictions of disease risk from smoking can be obtained based on available cigarette yield data for use in determining: |
| (i) How the risk assessment-calculated risks compare among three types of conventional cigarettes (regular, light, ultralight) and for PREPs; |
| (ii) How risk assessment-calculated risks for regular, light, and ultralight cigarettes comport with the observed levels of risk of smoking conventional cigarettes; |
| (iii) Whether the risk assessment-predicted levels of risk for PREP cigarettes are meaningfully lower than risks from conventional cigarettes. |
| (a) Cigarette smoking causes considerable human disease, including many cases of lung cancer. |
| (b) Risk assessment methods use toxicant-by-toxicant exposure estimates to predict estimates of the incidence of cancer in humans. |
| (c) Cigarette yield data are available that give the per cigarette deliveries of some toxicants of interest in cigarette smoke. |
| (d) Risk assessment predictions of disease risk from smoking can be obtained based on available cigarette yield data for use in determining: |
| (i) How the risk assessment-calculated risks compare among three types of conventional cigarettes (regular, light, ultralight) and for PREPs; |
| (ii) How risk assessment-calculated risks for regular, light, and ultralight cigarettes comport with the observed levels of risk of smoking conventional cigarettes; |
| (iii) Whether the risk assessment-predicted levels of risk for PREP cigarettes are meaningfully lower than risks from conventional cigarettes. |