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Table 2.

Acrylamide and glycidamide adduct values in individuals with PC concentrations <10 and ≥10 ng/mL

Acrylamide adducts (pmol/g Hb)
Glycidamide adducts (pmol/g Hb)
Glycidamide to acrylamide adduct ratio
PC < 10 ng/mL*
PC ≥ 10 ng/mL*
PC < 10 ng/mL
PC ≥ 10 ng/mL
PC < 10 ng/mL
PC ≥ 10 ng/mL
N

73
88
73
88
73
88
Median (95% CI)51 (46-56)194 (164-215)34 (31-36)107 (86-123)0.67 (0.63-0.74)0.55 (0.51-0.59)
Percentiles Min 60 17 0.11 0.03 
 29 87 16 41 0.42 0.32 
 25 40 128 28 71 0.56 0.46 
 50 51 194 34 107 0.67 0.55 
 75 63 255 41 143 0.81 0.65 
 95 155 403 117 215 1.03 0.92 
 Max 610 584 319 364 1.13 1.14 
        
  Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
N
 
 25
 
48
 
69
 
19
 
25
 
48
 
69
 
19
 
25
 
48
 
69
 
19
 
Median (95% CI)
 
 49 (40-66)
 
52 (46-57)
 
194 (155-215)
 
182 (129-235)
 
33 (28-40)
 
34 (31-37)
 
100 (82-121)
 
138 (70-150)
 
0.56 (0.53-0.79)
 
0.72 (0.62-0.79)
 
0.53§ (0.49 -0.59)
 
0.61§ (55-74)
 
Percentiles Min 20 60 72 17 44 0.11 0.38 0.03 0.46 
 23 32 88 91 11 21 36 51 0.29 0.46 0.29 0.47 
 25 39 41 125 139 27 29 71 74 0.52 0.62 0.42 0.55 
 50 49 52 194 182 33 34 100 138 0.56 0.72 0.53 0.61 
 75 70 61 263 231 42 40 134 149 0.76 0.86 0.64 0.73 
 95 299 97 456 325 162 107 214 195 0.82 1.06 0.92 0.89 
 Max 610 178 548 399 319 158 364 260 0.89 1.13 1.14 0.94 
Acrylamide adducts (pmol/g Hb)
Glycidamide adducts (pmol/g Hb)
Glycidamide to acrylamide adduct ratio
PC < 10 ng/mL*
PC ≥ 10 ng/mL*
PC < 10 ng/mL
PC ≥ 10 ng/mL
PC < 10 ng/mL
PC ≥ 10 ng/mL
N

73
88
73
88
73
88
Median (95% CI)51 (46-56)194 (164-215)34 (31-36)107 (86-123)0.67 (0.63-0.74)0.55 (0.51-0.59)
Percentiles Min 60 17 0.11 0.03 
 29 87 16 41 0.42 0.32 
 25 40 128 28 71 0.56 0.46 
 50 51 194 34 107 0.67 0.55 
 75 63 255 41 143 0.81 0.65 
 95 155 403 117 215 1.03 0.92 
 Max 610 584 319 364 1.13 1.14 
        
  Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
Men
 
Women
 
N
 
 25
 
48
 
69
 
19
 
25
 
48
 
69
 
19
 
25
 
48
 
69
 
19
 
Median (95% CI)
 
 49 (40-66)
 
52 (46-57)
 
194 (155-215)
 
182 (129-235)
 
33 (28-40)
 
34 (31-37)
 
100 (82-121)
 
138 (70-150)
 
0.56 (0.53-0.79)
 
0.72 (0.62-0.79)
 
0.53§ (0.49 -0.59)
 
0.61§ (55-74)
 
Percentiles Min 20 60 72 17 44 0.11 0.38 0.03 0.46 
 23 32 88 91 11 21 36 51 0.29 0.46 0.29 0.47 
 25 39 41 125 139 27 29 71 74 0.52 0.62 0.42 0.55 
 50 49 52 194 182 33 34 100 138 0.56 0.72 0.53 0.61 
 75 70 61 263 231 42 40 134 149 0.76 0.86 0.64 0.73 
 95 299 97 456 325 162 107 214 195 0.82 1.06 0.92 0.89 
 Max 610 178 548 399 319 158 364 260 0.89 1.13 1.14 0.94 
*

Smoking status was assigned based on categories described by Benowitz (28) with presumed smokers having plasma cotinine values of ≥10 ng/mL and presumed nonsmokers <10 ng/mL.

Significant differences (P < 0.0001).

Significant differences (P < 0.005).

§

Significant differences (P < 0.05).

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