American Association for Cancer Research

Table 2.

Acrylamide and glycidamide adduct values in individuals with PC concentrations <10 and ≥10 ng/mL

		Acrylamide adducts (pmol/g Hb)			Glycidamide adducts (pmol/g Hb)			Glycidamide to acrylamide adduct ratio
		PC < 10 ng/mL*	PC ≥ 10 ng/mL*	PC < 10 ng/mL	PC ≥ 10 ng/mL	PC < 10 ng/mL	PC ≥ 10 ng/mL
N			73	88	73	88	73	88
Median (95% CI)			51 (46-56)	194 (164-215)	34 (31-36)	107 (86-123)	0.67^† (0.63-0.74)	0.55^† (0.51-0.59)
Percentiles	Min	7	60	4	17	0.11	0.03
		5	29	87	16	41	0.42	0.32
		25	40	128	28	71	0.56	0.46
		50	51	194	34	107	0.67	0.55
		75	63	255	41	143	0.81	0.65
		95	155	403	117	215	1.03	0.92
		Max	610	584	319	364	1.13	1.14

			Men	Women	Men	Women	Men	Women	Men	Women	Men	Women	Men	Women
N			25	48	69	19	25	48	69	19	25	48	69	19
Median (95% CI)			49 (40-66)	52 (46-57)	194 (155-215)	182 (129-235)	33 (28-40)	34 (31-37)	100 (82-121)	138 (70-150)	0.56^‡ (0.53-0.79)	0.72^‡ (0.62-0.79)	0.53^§ (0.49 -0.59)	0.61^§ (55-74)
Percentiles	Min	20	7	60	72	4	7	17	44	0.11	0.38	0.03	0.46
		5	23	32	88	91	11	21	36	51	0.29	0.46	0.29	0.47
		25	39	41	125	139	27	29	71	74	0.52	0.62	0.42	0.55
		50	49	52	194	182	33	34	100	138	0.56	0.72	0.53	0.61
		75	70	61	263	231	42	40	134	149	0.76	0.86	0.64	0.73
		95	299	97	456	325	162	107	214	195	0.82	1.06	0.92	0.89
		Max	610	178	548	399	319	158	364	260	0.89	1.13	1.14	0.94

		Acrylamide adducts (pmol/g Hb)			Glycidamide adducts (pmol/g Hb)			Glycidamide to acrylamide adduct ratio
		PC < 10 ng/mL*	PC ≥ 10 ng/mL*	PC < 10 ng/mL	PC ≥ 10 ng/mL	PC < 10 ng/mL	PC ≥ 10 ng/mL
N			73	88	73	88	73	88
Median (95% CI)			51 (46-56)	194 (164-215)	34 (31-36)	107 (86-123)	0.67^† (0.63-0.74)	0.55^† (0.51-0.59)
Percentiles	Min	7	60	4	17	0.11	0.03
		5	29	87	16	41	0.42	0.32
		25	40	128	28	71	0.56	0.46
		50	51	194	34	107	0.67	0.55
		75	63	255	41	143	0.81	0.65
		95	155	403	117	215	1.03	0.92
		Max	610	584	319	364	1.13	1.14

			Men	Women	Men	Women	Men	Women	Men	Women	Men	Women	Men	Women
N			25	48	69	19	25	48	69	19	25	48	69	19
Median (95% CI)			49 (40-66)	52 (46-57)	194 (155-215)	182 (129-235)	33 (28-40)	34 (31-37)	100 (82-121)	138 (70-150)	0.56^‡ (0.53-0.79)	0.72^‡ (0.62-0.79)	0.53^§ (0.49 -0.59)	0.61^§ (55-74)
Percentiles	Min	20	7	60	72	4	7	17	44	0.11	0.38	0.03	0.46
		5	23	32	88	91	11	21	36	51	0.29	0.46	0.29	0.47
		25	39	41	125	139	27	29	71	74	0.52	0.62	0.42	0.55
		50	49	52	194	182	33	34	100	138	0.56	0.72	0.53	0.61
		75	70	61	263	231	42	40	134	149	0.76	0.86	0.64	0.73
		95	299	97	456	325	162	107	214	195	0.82	1.06	0.92	0.89
		Max	610	178	548	399	319	158	364	260	0.89	1.13	1.14	0.94

Smoking status was assigned based on categories described by Benowitz (28) with presumed smokers having plasma cotinine values of ≥10 ng/mL and presumed nonsmokers <10 ng/mL.

†

Significant differences (P < 0.0001).

‡

Significant differences (P < 0.005).

Significant differences (P < 0.05).

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