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Table 5.

Timing of first exposure to DES and characteristic dose of DES in relation to breast cancer among women ages ≥40 years

Person-years of follow-upNo. casesAge-adjusted IRR (95% CI)
Unexposed 13,058 17 Reference 
Weeks of gestation of first exposure    
    ≤8 wk 7,731 12 1.48 (0.69-3.16) 
    9-12 wk 6,511 14 2.04 (0.99-4.23) 
    ≥13 wk 8,272 19 2.01 (1.03-3.90) 
Characteristic dose in cohort*    
    Low dose 12,215 22 1.63 (0.86-3.11) 
    High dose 16,160 36 2.17 (1.18-3.97) 
    Unknown 973 1.75 (0.40-7.65) 
Person-years of follow-upNo. casesAge-adjusted IRR (95% CI)
Unexposed 13,058 17 Reference 
Weeks of gestation of first exposure    
    ≤8 wk 7,731 12 1.48 (0.69-3.16) 
    9-12 wk 6,511 14 2.04 (0.99-4.23) 
    ≥13 wk 8,272 19 2.01 (1.03-3.90) 
Characteristic dose in cohort*    
    Low dose 12,215 22 1.63 (0.86-3.11) 
    High dose 16,160 36 2.17 (1.18-3.97) 
    Unknown 973 1.75 (0.40-7.65) 
*

Low-dose cohort includes participants from hospitals in Texas, Minnesota, and Wisconsin. High-dose cohort includes participants from hospitals in Boston, Chicago, and California. Unknown includes participants from hospitals in New Hampshire and Maine.

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