American Association for Cancer Research

Table 3.

Prenatal DES exposure in relation to risk of invasive breast cancer

	Exposed			Unexposed			Age-adjusted IRR* (95% CI)	Multivariable IRR^† (95% CI)
		Person-years of follow-up	Cases	Person-years of follow-up	Cases		Age-adjusted IRR* (95% CI)	Multivariable IRR^† (95% CI)
Entire cohort	98,591	76	35,046	26	1.40 (0.89-2.22)	1.40 (0.86-2.29)
Age <40 y	69,243	16	21,988	9	0.61 (0.27-1.38)	0.57 (0.24-1.34)
Age ≥40 y	29,348	60	13,058	17	1.91 (1.09-3.33)	2.05 (1.12-3.76)
Age 40-49 y	26,433	46	10,843	12	1.60 (0.85-3.02)	1.62 (0.83-3.18)
Age ≥50 y	2,915	14	2,215	5	3.00 (1.01-8.98)	3.85 (1.06-14.0)

	Exposed			Unexposed			Age-adjusted IRR* (95% CI)	Multivariable IRR^† (95% CI)
		Person-years of follow-up	Cases	Person-years of follow-up	Cases		Age-adjusted IRR* (95% CI)	Multivariable IRR^† (95% CI)
Entire cohort	98,591	76	35,046	26	1.40 (0.89-2.22)	1.40 (0.86-2.29)
Age <40 y	69,243	16	21,988	9	0.61 (0.27-1.38)	0.57 (0.24-1.34)
Age ≥40 y	29,348	60	13,058	17	1.91 (1.09-3.33)	2.05 (1.12-3.76)
Age 40-49 y	26,433	46	10,843	12	1.60 (0.85-3.02)	1.62 (0.83-3.18)
Age ≥50 y	2,915	14	2,215	5	3.00 (1.01-8.98)	3.85 (1.06-14.0)

IRR for breast cancer incidence in exposed women relative to unexposed.

†

Adjusted for age, years of education, number of births, age at 1st birth, age at menarche, use of female hormone supplements, use of oral contraceptives, family history of breast cancer, birthweight, and cohort.

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