Joint effects of CYP1A2*1F and age at menarche, body mass index, hormone replacement therapy use, and pack-years on breast cancer risk
| . | AA . | . | AC . | . | CC . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | n* . | OR† (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| Age at menarche (y) | ||||||||||||
| <12 | 347/320 | 1.0 | 336/318 | 0.9 (0.7-1.1) | 46/65 | 0.6 (0.4-1.0) | ||||||
| 13-14 | 217/214 | 0.7 (0.3-1.5) | 208/240 | 0.6 (0.2-1.2) | 34/43 | 0.6 (0.2-1.5) | ||||||
| >14 | 66/71 | 0.5 (0.1-2.7) | 59/62 | 0.5 (0.1-2.5) | 9/14 | 0.4 (0.1-2.3) | ||||||
| Pinteraction | 0.20‡ | |||||||||||
| Body mass index (kg/m2) | ||||||||||||
| <23.8 | 244/203 | 1.0 | 247/207 | 0.9 (0.7-1.2) | 30/31 | 0.8 (0.5-1.4) | ||||||
| 23.9-28.2 | 213/194 | 1.1 (0.8-1.4) | 185/215 | 0.8 (0.6-1.0) | 32/43 | 0.7 (0.4-1.2) | ||||||
| >28.2 | 173/208 | 1.0 (0.7-1.3) | 171/198 | 1.0 (0.7-1.3) | 27/48 | 0.7 (0.4-1.2) | ||||||
| Pinteraction | 0.51 | |||||||||||
| Hormone replacement therapy use (y) | ||||||||||||
| Never | 270/325 | 1.0 | 255/314 | 0.9 (0.7-1.2) | 41/59 | 0.9 (0.6-1.4) | ||||||
| <5 | 186/154 | 1.3 (1.0-1.7) | 171/183 | 0.9 (0.7-1.2) | 26/36 | 0.8 (0.4-1.3) | ||||||
| >5 | 167/109 | 1.3 (1.0-1.8) | 162/108 | 1.2 (0.9-1.7) | 19/24 | 0.7 (0.4-1.4) | ||||||
| Pinteraction | 0.51 | |||||||||||
| Pack-years | ||||||||||||
| 0 | 346/329 | 1.0 | 339/360 | 0.8 (0.7-1.0) | 48/74 | 0.6 (0.4-1.0) | ||||||
| 0.1-12.0 | 150/155 | 1.0 (0.8-1.3) | 136/146 | 1.0 (0.7-1.3) | 20/28 | 0.8 (0.4-1.5) | ||||||
| >12.0 | 134/121 | 1.1 (0.8-1.4) | 128/114 | 1.0 (0.8-1.4) | 21/20 | 1.1 (0.6-2.1) | ||||||
| Pinteraction | 0.76 | |||||||||||
| . | AA . | . | AC . | . | CC . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | n* . | OR† (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| Age at menarche (y) | ||||||||||||
| <12 | 347/320 | 1.0 | 336/318 | 0.9 (0.7-1.1) | 46/65 | 0.6 (0.4-1.0) | ||||||
| 13-14 | 217/214 | 0.7 (0.3-1.5) | 208/240 | 0.6 (0.2-1.2) | 34/43 | 0.6 (0.2-1.5) | ||||||
| >14 | 66/71 | 0.5 (0.1-2.7) | 59/62 | 0.5 (0.1-2.5) | 9/14 | 0.4 (0.1-2.3) | ||||||
| Pinteraction | 0.20‡ | |||||||||||
| Body mass index (kg/m2) | ||||||||||||
| <23.8 | 244/203 | 1.0 | 247/207 | 0.9 (0.7-1.2) | 30/31 | 0.8 (0.5-1.4) | ||||||
| 23.9-28.2 | 213/194 | 1.1 (0.8-1.4) | 185/215 | 0.8 (0.6-1.0) | 32/43 | 0.7 (0.4-1.2) | ||||||
| >28.2 | 173/208 | 1.0 (0.7-1.3) | 171/198 | 1.0 (0.7-1.3) | 27/48 | 0.7 (0.4-1.2) | ||||||
| Pinteraction | 0.51 | |||||||||||
| Hormone replacement therapy use (y) | ||||||||||||
| Never | 270/325 | 1.0 | 255/314 | 0.9 (0.7-1.2) | 41/59 | 0.9 (0.6-1.4) | ||||||
| <5 | 186/154 | 1.3 (1.0-1.7) | 171/183 | 0.9 (0.7-1.2) | 26/36 | 0.8 (0.4-1.3) | ||||||
| >5 | 167/109 | 1.3 (1.0-1.8) | 162/108 | 1.2 (0.9-1.7) | 19/24 | 0.7 (0.4-1.4) | ||||||
| Pinteraction | 0.51 | |||||||||||
| Pack-years | ||||||||||||
| 0 | 346/329 | 1.0 | 339/360 | 0.8 (0.7-1.0) | 48/74 | 0.6 (0.4-1.0) | ||||||
| 0.1-12.0 | 150/155 | 1.0 (0.8-1.3) | 136/146 | 1.0 (0.7-1.3) | 20/28 | 0.8 (0.4-1.5) | ||||||
| >12.0 | 134/121 | 1.1 (0.8-1.4) | 128/114 | 1.0 (0.8-1.4) | 21/20 | 1.1 (0.6-2.1) | ||||||
| Pinteraction | 0.76 | |||||||||||
Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.
No. of cases/no. of controls. Numbers of subjects vary due to missing information.
ORs (95% CIs) adjusted for age at blood draw, age at menarche, parity, and age at first birth.
P value derived from a likelihood ratio test comparing a model with main effects for the CYP1A2*1F genotype and the risk factor, and a model with main effects and interaction terms.