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Table 4.

Joint effects of CYP1A2*1F and age at menarche, body mass index, hormone replacement therapy use, and pack-years on breast cancer risk

AA
AC
CC
n*OR (95% CI)nOR (95% CI)nOR (95% CI)
Age at menarche (y)       
    <12 347/320 1.0 336/318 0.9 (0.7-1.1) 46/65 0.6 (0.4-1.0) 
    13-14 217/214 0.7 (0.3-1.5) 208/240 0.6 (0.2-1.2) 34/43 0.6 (0.2-1.5) 
    >14 66/71 0.5 (0.1-2.7) 59/62 0.5 (0.1-2.5) 9/14 0.4 (0.1-2.3) 
    Pinteraction    0.20   
Body mass index (kg/m2      
    <23.8 244/203 1.0 247/207 0.9 (0.7-1.2) 30/31 0.8 (0.5-1.4) 
    23.9-28.2 213/194 1.1 (0.8-1.4) 185/215 0.8 (0.6-1.0) 32/43 0.7 (0.4-1.2) 
    >28.2 173/208 1.0 (0.7-1.3) 171/198 1.0 (0.7-1.3) 27/48 0.7 (0.4-1.2) 
    Pinteraction    0.51   
Hormone replacement therapy use (y)       
    Never 270/325 1.0 255/314 0.9 (0.7-1.2) 41/59 0.9 (0.6-1.4) 
    <5 186/154 1.3 (1.0-1.7) 171/183 0.9 (0.7-1.2) 26/36 0.8 (0.4-1.3) 
    >5 167/109 1.3 (1.0-1.8) 162/108 1.2 (0.9-1.7) 19/24 0.7 (0.4-1.4) 
    Pinteraction    0.51   
Pack-years       
    0 346/329 1.0 339/360 0.8 (0.7-1.0) 48/74 0.6 (0.4-1.0) 
    0.1-12.0 150/155 1.0 (0.8-1.3) 136/146 1.0 (0.7-1.3) 20/28 0.8 (0.4-1.5) 
    >12.0 134/121 1.1 (0.8-1.4) 128/114 1.0 (0.8-1.4) 21/20 1.1 (0.6-2.1) 
    Pinteraction    0.76   
AA
AC
CC
n*OR (95% CI)nOR (95% CI)nOR (95% CI)
Age at menarche (y)       
    <12 347/320 1.0 336/318 0.9 (0.7-1.1) 46/65 0.6 (0.4-1.0) 
    13-14 217/214 0.7 (0.3-1.5) 208/240 0.6 (0.2-1.2) 34/43 0.6 (0.2-1.5) 
    >14 66/71 0.5 (0.1-2.7) 59/62 0.5 (0.1-2.5) 9/14 0.4 (0.1-2.3) 
    Pinteraction    0.20   
Body mass index (kg/m2      
    <23.8 244/203 1.0 247/207 0.9 (0.7-1.2) 30/31 0.8 (0.5-1.4) 
    23.9-28.2 213/194 1.1 (0.8-1.4) 185/215 0.8 (0.6-1.0) 32/43 0.7 (0.4-1.2) 
    >28.2 173/208 1.0 (0.7-1.3) 171/198 1.0 (0.7-1.3) 27/48 0.7 (0.4-1.2) 
    Pinteraction    0.51   
Hormone replacement therapy use (y)       
    Never 270/325 1.0 255/314 0.9 (0.7-1.2) 41/59 0.9 (0.6-1.4) 
    <5 186/154 1.3 (1.0-1.7) 171/183 0.9 (0.7-1.2) 26/36 0.8 (0.4-1.3) 
    >5 167/109 1.3 (1.0-1.8) 162/108 1.2 (0.9-1.7) 19/24 0.7 (0.4-1.4) 
    Pinteraction    0.51   
Pack-years       
    0 346/329 1.0 339/360 0.8 (0.7-1.0) 48/74 0.6 (0.4-1.0) 
    0.1-12.0 150/155 1.0 (0.8-1.3) 136/146 1.0 (0.7-1.3) 20/28 0.8 (0.4-1.5) 
    >12.0 134/121 1.1 (0.8-1.4) 128/114 1.0 (0.8-1.4) 21/20 1.1 (0.6-2.1) 
    Pinteraction    0.76   

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

*

No. of cases/no. of controls. Numbers of subjects vary due to missing information.

ORs (95% CIs) adjusted for age at blood draw, age at menarche, parity, and age at first birth.

P value derived from a likelihood ratio test comparing a model with main effects for the CYP1A2*1F genotype and the risk factor, and a model with main effects and interaction terms.

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