American Association for Cancer Research

Table 2.

Breast cancer odds ratios (95% confidence intervals) by genotype

Genotype	n^*	Odds ratio^† (95% confidence interval)	Odds ratio^‡ (95% confidence interval)
CYP1A12A*
TT	743/722	1.0	1.0
TC	493/530	1.0 (0.9-1.2)	1.0 (0.8-1.2)
CC	103/118	1.0 (0.8-1.4)	1.0 (0.6-1.4)
P		0.78^§	0.85
CYP1A2*1F
AA	640/617	1.0	1.0
AC	608/627	0.9 (0.7-1.0)	0.9 (0.7-1.0)
CC	91/125	0.8 (0.6-1.0)	0.7 (0.5-1.0)
P		0.03	0.03
CYP1B1 Leu⁴³²Val
LL	581/516	1.0	1.0
LV	495/525	1.0 (0.8-1.1)	0.9 (0.8-1.1)
VV	263/329	0.9 (0.7-1.2)	0.9 (0.7-1.1)
P		0.47	0.32
AHR Arg⁵⁵⁴Lys
RR	721/756	1.0	1.0
RL	463/456	1.1 (0.9-1.3)	1.1 (0.9-1.3)
LL	155/158	1.0 (0.8-1.3)	1.0 (0.7-1.3)
P		0.62	0.75
CYP3A41B*
AA	1,080/994	1.0	1.0
AG	164/254	0.9 (0.7-1.2)	0.9 (0.7-1.2)
GG	95/122	1.1 (0.6-1.6)	1.1 (0.8-1.7)
P		0.66	0.68
COMT Val¹⁵⁸Met
Val/Val	519/550	1.0	1.0
Val/Met	624/614	1.0 (0.9-1.2)	1.0 (0.8-1.2)
Met/Met	196/206	0.9 (0.7-1.2)	0.9 (0.7-1.2)
P		0.71	0.64
SULT1A1 Arg²¹³His
Arg/Arg	801/782	1.0	1.0
Arg/His	424/484	0.9 (0.7-1.0)	0.9 (0.7-1.0)
His/His	114/104	1.1 (0.8-1.5)	1.1 (0.8-1.5)
P		0.63	0.63

Genotype	n^*	Odds ratio^† (95% confidence interval)	Odds ratio^‡ (95% confidence interval)
CYP1A12A*
TT	743/722	1.0	1.0
TC	493/530	1.0 (0.9-1.2)	1.0 (0.8-1.2)
CC	103/118	1.0 (0.8-1.4)	1.0 (0.6-1.4)
P		0.78^§	0.85
CYP1A2*1F
AA	640/617	1.0	1.0
AC	608/627	0.9 (0.7-1.0)	0.9 (0.7-1.0)
CC	91/125	0.8 (0.6-1.0)	0.7 (0.5-1.0)
P		0.03	0.03
CYP1B1 Leu⁴³²Val
LL	581/516	1.0	1.0
LV	495/525	1.0 (0.8-1.1)	0.9 (0.8-1.1)
VV	263/329	0.9 (0.7-1.2)	0.9 (0.7-1.1)
P		0.47	0.32
AHR Arg⁵⁵⁴Lys
RR	721/756	1.0	1.0
RL	463/456	1.1 (0.9-1.3)	1.1 (0.9-1.3)
LL	155/158	1.0 (0.8-1.3)	1.0 (0.7-1.3)
P		0.62	0.75
CYP3A41B*
AA	1,080/994	1.0	1.0
AG	164/254	0.9 (0.7-1.2)	0.9 (0.7-1.2)
GG	95/122	1.1 (0.6-1.6)	1.1 (0.8-1.7)
P		0.66	0.68
COMT Val¹⁵⁸Met
Val/Val	519/550	1.0	1.0
Val/Met	624/614	1.0 (0.9-1.2)	1.0 (0.8-1.2)
Met/Met	196/206	0.9 (0.7-1.2)	0.9 (0.7-1.2)
P		0.71	0.64
SULT1A1 Arg²¹³His
Arg/Arg	801/782	1.0	1.0
Arg/His	424/484	0.9 (0.7-1.0)	0.9 (0.7-1.0)
His/His	114/104	1.1 (0.8-1.5)	1.1 (0.8-1.5)
P		0.63	0.63

No. cases/No. controls.

Odds ratios adjusted for age at blood draw and race/ethnicity.

Odds ratios further adjusted for age at menarche, parity, and age at first birth.

P value for gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.