Relationship between combined MTHFR genotypes and MSI by folate intake status
| Combined MTHFR genotypes . | . | Total folate (μg) . | MSI . | MSS . | OR* (95% CI) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| (A) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with high folate intake | ||||||||||
| MTHFR 677 | MTHFR 1298 | |||||||||
| CC | AA | ≥400 | 8 | 23 | Reference | |||||
| CC | AC/CC | ≥400 | 3 | 44 | 0.09 (0.01, 0.59) | |||||
| CT/TT | AA | ≥400 | 3 | 28 | 0.13 (0.02, 0.85) | |||||
| CT/TT | AC/CC | ≥400 | 0 | 15 | ND | |||||
| (B) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with low folate intake | ||||||||||
| MTHFR 677 | MTHFR 1298 | |||||||||
| CC | AA | <400 | 6 | 64 | Reference | |||||
| CC | AC/CC | <400 | 12 | 62 | 1.47 (0.43-4.99) | |||||
| CT/TT | AA | <400 | 5 | 57 | 0.68 (0.16-2.78) | |||||
| CT/TT | AC/CC | <400 | 3 | 17 | 1.20 (0.20-7.32) | |||||
| Combined MTHFR genotypes . | . | Total folate (μg) . | MSI . | MSS . | OR* (95% CI) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| (A) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with high folate intake | ||||||||||
| MTHFR 677 | MTHFR 1298 | |||||||||
| CC | AA | ≥400 | 8 | 23 | Reference | |||||
| CC | AC/CC | ≥400 | 3 | 44 | 0.09 (0.01, 0.59) | |||||
| CT/TT | AA | ≥400 | 3 | 28 | 0.13 (0.02, 0.85) | |||||
| CT/TT | AC/CC | ≥400 | 0 | 15 | ND | |||||
| (B) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with low folate intake | ||||||||||
| MTHFR 677 | MTHFR 1298 | |||||||||
| CC | AA | <400 | 6 | 64 | Reference | |||||
| CC | AC/CC | <400 | 12 | 62 | 1.47 (0.43-4.99) | |||||
| CT/TT | AA | <400 | 5 | 57 | 0.68 (0.16-2.78) | |||||
| CT/TT | AC/CC | <400 | 3 | 17 | 1.20 (0.20-7.32) | |||||
Abbreviation: ND, not determined.
Adjusted for age, race, tumor location, smoking status, total calcium intake, and vitamin/mineral supplement use.