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Table 4.

Relationship between combined MTHFR genotypes and MSI by folate intake status

Combined MTHFR genotypesTotal folate (μg)MSIMSSOR* (95% CI)
(A) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with high folate intake      
    MTHFR 677 MTHFR 1298     
    CC AA ≥400 23 Reference 
    CC AC/CC ≥400 44 0.09 (0.01, 0.59) 
    CT/TT AA ≥400 28 0.13 (0.02, 0.85) 
    CT/TT AC/CC ≥400 15 ND 
      
(B) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with low folate intake      
    MTHFR 677 MTHFR 1298     
    CC AA <400 64 Reference 
    CC AC/CC <400 12 62 1.47 (0.43-4.99) 
    CT/TT AA <400 57 0.68 (0.16-2.78) 
    CT/TT AC/CC <400 17 1.20 (0.20-7.32) 
Combined MTHFR genotypesTotal folate (μg)MSIMSSOR* (95% CI)
(A) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with high folate intake      
    MTHFR 677 MTHFR 1298     
    CC AA ≥400 23 Reference 
    CC AC/CC ≥400 44 0.09 (0.01, 0.59) 
    CT/TT AA ≥400 28 0.13 (0.02, 0.85) 
    CT/TT AC/CC ≥400 15 ND 
      
(B) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with low folate intake      
    MTHFR 677 MTHFR 1298     
    CC AA <400 64 Reference 
    CC AC/CC <400 12 62 1.47 (0.43-4.99) 
    CT/TT AA <400 57 0.68 (0.16-2.78) 
    CT/TT AC/CC <400 17 1.20 (0.20-7.32) 

Abbreviation: ND, not determined.

*

Adjusted for age, race, tumor location, smoking status, total calcium intake, and vitamin/mineral supplement use.

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