Adjusted ORs and 95% CIs for MSI in relation to MTHFR genotypes and total, dietary, and supplemental folate
| Genotype . | Total folate (μg) . | MSI . | MSS . | OR* (95% CI) . | Dietary folate (μg) . | MSI . | MSS . | OR* (95% CI) . | Supplemental folate use . | MSI . | MSS . | OR* (95% CI) . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MTHFR 1298 | ||||||||||||||||||||||||
| AA | ≥400 | 11 | 63 | Reference | ≥275 | 5 | 89 | Reference | Yes | 10 | 58 | Reference | ||||||||||||
| AC/CC | ≥400 | 3 | 73 | 0.18 (0.04-0.73) | ≥275 | 10 | 75 | 1.63 (0.49-5.44) | Yes | 1 | 53 | 0.10 (0.01-0.81) | ||||||||||||
| AA | <400 | 12 | 147 | 0.51 (0.16-1.62) | <275 | 18 | 121 | 2.46 (0.79-7.67) | No | 13 | 152 | 0.62 (0.18-2.11) | ||||||||||||
| AC/CC | <400 | 16 | 94 | 0.83 (0.26-2.64) | <275 | 9 | 92 | 1.17 (0.33-4.20) | No | 18 | 114 | 0.82 (0.24-2.76) | ||||||||||||
| MTHFR 677 | ||||||||||||||||||||||||
| CC | ≥400 | 12 | 76 | Reference | ≥275 | 15 | 96 | Reference | Yes | 8 | 64 | Reference | ||||||||||||
| CT/TT | ≥400 | 3 | 58 | 0.29 (0.07-1.17) | ≥275 | 2 | 66 | 0.11 (0.02-0.52) | Yes | 3 | 46 | 0.51 (0.12-2.23) | ||||||||||||
| CC | <400 | 21 | 156 | 0.92 (0.33-2.59) | <275 | 18 | 136 | 0.67 (0.27-1.68) | No | 25 | 168 | 1.23 (0.34-4.41) | ||||||||||||
| CT/TT | <400 | 8 | 85 | 0.53 (0.16-1.79) | <275 | 9 | 77 | 0.72 (0.26-2.00) | No | 8 | 97 | 0.54 (0.13-2.34) | ||||||||||||
| Genotype . | Total folate (μg) . | MSI . | MSS . | OR* (95% CI) . | Dietary folate (μg) . | MSI . | MSS . | OR* (95% CI) . | Supplemental folate use . | MSI . | MSS . | OR* (95% CI) . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MTHFR 1298 | ||||||||||||||||||||||||
| AA | ≥400 | 11 | 63 | Reference | ≥275 | 5 | 89 | Reference | Yes | 10 | 58 | Reference | ||||||||||||
| AC/CC | ≥400 | 3 | 73 | 0.18 (0.04-0.73) | ≥275 | 10 | 75 | 1.63 (0.49-5.44) | Yes | 1 | 53 | 0.10 (0.01-0.81) | ||||||||||||
| AA | <400 | 12 | 147 | 0.51 (0.16-1.62) | <275 | 18 | 121 | 2.46 (0.79-7.67) | No | 13 | 152 | 0.62 (0.18-2.11) | ||||||||||||
| AC/CC | <400 | 16 | 94 | 0.83 (0.26-2.64) | <275 | 9 | 92 | 1.17 (0.33-4.20) | No | 18 | 114 | 0.82 (0.24-2.76) | ||||||||||||
| MTHFR 677 | ||||||||||||||||||||||||
| CC | ≥400 | 12 | 76 | Reference | ≥275 | 15 | 96 | Reference | Yes | 8 | 64 | Reference | ||||||||||||
| CT/TT | ≥400 | 3 | 58 | 0.29 (0.07-1.17) | ≥275 | 2 | 66 | 0.11 (0.02-0.52) | Yes | 3 | 46 | 0.51 (0.12-2.23) | ||||||||||||
| CC | <400 | 21 | 156 | 0.92 (0.33-2.59) | <275 | 18 | 136 | 0.67 (0.27-1.68) | No | 25 | 168 | 1.23 (0.34-4.41) | ||||||||||||
| CT/TT | <400 | 8 | 85 | 0.53 (0.16-1.79) | <275 | 9 | 77 | 0.72 (0.26-2.00) | No | 8 | 97 | 0.54 (0.13-2.34) | ||||||||||||
Adjusted for age, race, tumor location, smoking status, total calcium intake, and vitamin/mineral supplement use.