American Association for Cancer Research

Table 1.

Analyses of human leukocyte antigen (HLA) and TNFb microsatellite variants previously associated with malignant glioma and related diseases in various cohorts

Genetic variants	Reported association	Distribution, {n (%)} in:			OR	P*
Genetic variants	Reported association			155 Cases	OR	P*	157 Controls
A24^†	Positive	24 (15.5)	25 (15.9)	0.97	0.92
A*25^‡	Positive	6 (3.9)	8 (5.1)	0.75	0.60
B*27^‡	Positive	11 (7.1)	11 (7.0)	1.01	0.97
DRB1*15^‡	Positive	39 (25.2)	39 (24.8)	1.02	0.95
DRB1*07^‡	Negative	34 (21.9)	38 (24.2)	0.88	0.63
Cw06-DRB107^‡	Negative	13 (8.4)	11 (7.0)	1.22	0.65
TNFb allele 4 (b4) hmz^§	Positive	33 (21.3)	23 (14.6)	1.58	0.13

Genetic variants	Reported association	Distribution, {n (%)} in:			OR	P*
Genetic variants	Reported association			155 Cases	OR	P*	157 Controls
A24^†	Positive	24 (15.5)	25 (15.9)	0.97	0.92
A*25^‡	Positive	6 (3.9)	8 (5.1)	0.75	0.60
B*27^‡	Positive	11 (7.1)	11 (7.0)	1.01	0.97
DRB1*15^‡	Positive	39 (25.2)	39 (24.8)	1.02	0.95
DRB1*07^‡	Negative	34 (21.9)	38 (24.2)	0.88	0.63
Cw06-DRB107^‡	Negative	13 (8.4)	11 (7.0)	1.22	0.65
TNFb allele 4 (b4) hmz^§	Positive	33 (21.3)	23 (14.6)	1.58	0.13

Based on maximum likelihood Chi-square tests.

†

From a study of 42 Japanese patients (39).

‡

From a study of 65 German patients (41).

Hmz, homozygosity, from a study of 48 Italian patients (40).

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