Numbers of case-control pairs required to attain a significance level of α = 1 × 10−7 with 95% power in a single-stage study, assuming a multiplicative genetic model with the indicated relative risks per allele (i.e., homozygote relative risk being the square of the indicated relative risks)
| Relative risk . | MAF = 5% . | MAF = 10% . | MAF = 20% . |
|---|---|---|---|
| 1.2 | 28,000 | 15,000 | 8,700 |
| 1.5 | 5,200 | 2,800 | 1,700 |
| 2.0 | 1,600 | 870 | 540 |
| 2.5 | 830 | 470 | 300 |
| 3.0 | 540 | 310 | 200 |
| Relative risk . | MAF = 5% . | MAF = 10% . | MAF = 20% . |
|---|---|---|---|
| 1.2 | 28,000 | 15,000 | 8,700 |
| 1.5 | 5,200 | 2,800 | 1,700 |
| 2.0 | 1,600 | 870 | 540 |
| 2.5 | 830 | 470 | 300 |
| 3.0 | 540 | 310 | 200 |
Abbreviation: MAF, minor allele frequency.