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Table 1.

Numbers of case-control pairs required to attain a significance level of α = 1 × 10−7 with 95% power in a single-stage study, assuming a multiplicative genetic model with the indicated relative risks per allele (i.e., homozygote relative risk being the square of the indicated relative risks)

Relative riskMAF = 5%MAF = 10%MAF = 20%
1.2 28,000 15,000 8,700 
1.5 5,200 2,800 1,700 
2.0 1,600 870 540 
2.5 830 470 300 
3.0 540 310 200 
Relative riskMAF = 5%MAF = 10%MAF = 20%
1.2 28,000 15,000 8,700 
1.5 5,200 2,800 1,700 
2.0 1,600 870 540 
2.5 830 470 300 
3.0 540 310 200 

Abbreviation: MAF, minor allele frequency.

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