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Table 1.

Genetic variants of methionine metabolism in glioblastoma multiforme patients and controls

MTHFR c.677C>TCCCTTTPearson: χ2; PRegression: χ2; P
Patients (n = 328) 0.42 0.46 0.12 χ2 = 2.30; P = 0.316 χ2 = 3.55; P = 0.169 
Controls (n = 400) 0.46 0.46 0.09   
      
MTR c.2756A>G AA AG GG χ2; P χ2; P 
Patients (n = 328) 0.72 0.26 0.02 χ2 = 17.86; P < 0.001 χ2 = 14.82; P = 0.001 
Controls (n = 400) 0.57 0.38 0.05   
      
Tc2 c.776C>G CC CG GG χ2; P χ2; P 
Patients (n = 328) 0.28 0.46 0.26 χ2 = 0.18; P = 0.912 χ2 = 0.735; P = 0.693 
Controls (n = 400) 0.28 0.45 0.28   
MTHFR c.677C>TCCCTTTPearson: χ2; PRegression: χ2; P
Patients (n = 328) 0.42 0.46 0.12 χ2 = 2.30; P = 0.316 χ2 = 3.55; P = 0.169 
Controls (n = 400) 0.46 0.46 0.09   
      
MTR c.2756A>G AA AG GG χ2; P χ2; P 
Patients (n = 328) 0.72 0.26 0.02 χ2 = 17.86; P < 0.001 χ2 = 14.82; P = 0.001 
Controls (n = 400) 0.57 0.38 0.05   
      
Tc2 c.776C>G CC CG GG χ2; P χ2; P 
Patients (n = 328) 0.28 0.46 0.26 χ2 = 0.18; P = 0.912 χ2 = 0.735; P = 0.693 
Controls (n = 400) 0.28 0.45 0.28   

NOTE: The rate of carriers of the different allelotypes is given as relative amount. The χ2 test values for Pearson's χ2 test for all three allelotypes (= 2 degrees of freedom) as well as for multiple nominal regression analysis (with simultaneous analysis of all three polymorphisms together with age and gender as covariables) for the differences between patients and controls are shown. The allelic frequencies in the control group are similar to those we reported for another (independent) healthy German population (12).

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