Estimation of SCCHN risk (OR and 95% CI) associated with expression levels of NER proteins
| Expression level* . | . | Cases . | Controls . | Crude OR (95% CI) . | Multivariate adjusted † OR (95% CI) . | Multivariate adjusted OR‡ (95% CI) . | |
|---|---|---|---|---|---|---|---|
| . | . | No. (%) . | No. (%) . | . | . | . | |
| ERCC1 | high | 17 (32) | 29 (50) | 2.12 (0.98-4.59) | 2.18 (0.91-5.24) | 0.78 (0.21-2.85) | |
| low | 36 (68) | 29 (50) | |||||
| XPA | high | 15 (28) | 30 (49) | 2.45 (1.12-5.35) | 2.99 (1.22-7.47) | 2.01 (0.57-7.14) | |
| low | 38 (72) | 31 (51) | |||||
| XPC | high | 13 (24) | 31 (50) | 3.15 (1.42-7.01) | 2.46 (1.04-5.87) | 1.17 (0.31-4.41) | |
| low | 41 (76) | 31 (50) | |||||
| XPD | high | 15 (29) | 29 (49) | 2.38 (1.09-5.24) | 3.02 (1.18-7.76) | 1.88 (0.50-7.01) | |
| low | 37 (71) | 30 (51) | |||||
| XPF | high | 13 (23) | 31 (50) | 3.31 (1.49-7.33) | 5.29 (2.01-13.9) | 11.5 (2.32-56.6) | |
| low | 43 (77) | 31 (50) | |||||
| XPG | high | 18 (33) | 30 (50) | 2.06 (0.96-4.38) | 1.56 (0.79-3.92) | 0.48 (0.13-1.74) | |
| low | 37 (67) | 30 (50) | |||||
| Expression level* . | . | Cases . | Controls . | Crude OR (95% CI) . | Multivariate adjusted † OR (95% CI) . | Multivariate adjusted OR‡ (95% CI) . | |
|---|---|---|---|---|---|---|---|
| . | . | No. (%) . | No. (%) . | . | . | . | |
| ERCC1 | high | 17 (32) | 29 (50) | 2.12 (0.98-4.59) | 2.18 (0.91-5.24) | 0.78 (0.21-2.85) | |
| low | 36 (68) | 29 (50) | |||||
| XPA | high | 15 (28) | 30 (49) | 2.45 (1.12-5.35) | 2.99 (1.22-7.47) | 2.01 (0.57-7.14) | |
| low | 38 (72) | 31 (51) | |||||
| XPC | high | 13 (24) | 31 (50) | 3.15 (1.42-7.01) | 2.46 (1.04-5.87) | 1.17 (0.31-4.41) | |
| low | 41 (76) | 31 (50) | |||||
| XPD | high | 15 (29) | 29 (49) | 2.38 (1.09-5.24) | 3.02 (1.18-7.76) | 1.88 (0.50-7.01) | |
| low | 37 (71) | 30 (51) | |||||
| XPF | high | 13 (23) | 31 (50) | 3.31 (1.49-7.33) | 5.29 (2.01-13.9) | 11.5 (2.32-56.6) | |
| low | 43 (77) | 31 (50) | |||||
| XPG | high | 18 (33) | 30 (50) | 2.06 (0.96-4.38) | 1.56 (0.79-3.92) | 0.48 (0.13-1.74) | |
| low | 37 (67) | 30 (50) | |||||
Dichotomized based on median values of control subjects.
Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, and lymphocyte storage time.
Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, lymphocytes.