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Table 4.

Estimation of SCCHN risk (OR and 95% CI) associated with expression levels of NER proteins

Expression level*Cases
Controls
Crude OR (95% CI)Multivariate adjusted OR (95% CI)Multivariate adjusted OR (95% CI)
No. (%)No. (%)
ERCC1 high 17 (32) 29 (50) 2.12 (0.98-4.59) 2.18 (0.91-5.24) 0.78 (0.21-2.85) 
 low 36 (68) 29 (50)    
XPA high 15 (28) 30 (49) 2.45 (1.12-5.35) 2.99 (1.22-7.47) 2.01 (0.57-7.14) 
 low 38 (72) 31 (51)    
XPC high 13 (24) 31 (50) 3.15 (1.42-7.01) 2.46 (1.04-5.87) 1.17 (0.31-4.41) 
 low 41 (76) 31 (50)    
XPD high 15 (29) 29 (49) 2.38 (1.09-5.24) 3.02 (1.18-7.76) 1.88 (0.50-7.01) 
 low 37 (71) 30 (51)    
XPF high 13 (23) 31 (50) 3.31 (1.49-7.33) 5.29 (2.01-13.9) 11.5 (2.32-56.6) 
 low 43 (77) 31 (50)    
XPG high 18 (33) 30 (50) 2.06 (0.96-4.38) 1.56 (0.79-3.92) 0.48 (0.13-1.74) 
 low 37 (67) 30 (50)    
Expression level*Cases
Controls
Crude OR (95% CI)Multivariate adjusted OR (95% CI)Multivariate adjusted OR (95% CI)
No. (%)No. (%)
ERCC1 high 17 (32) 29 (50) 2.12 (0.98-4.59) 2.18 (0.91-5.24) 0.78 (0.21-2.85) 
 low 36 (68) 29 (50)    
XPA high 15 (28) 30 (49) 2.45 (1.12-5.35) 2.99 (1.22-7.47) 2.01 (0.57-7.14) 
 low 38 (72) 31 (51)    
XPC high 13 (24) 31 (50) 3.15 (1.42-7.01) 2.46 (1.04-5.87) 1.17 (0.31-4.41) 
 low 41 (76) 31 (50)    
XPD high 15 (29) 29 (49) 2.38 (1.09-5.24) 3.02 (1.18-7.76) 1.88 (0.50-7.01) 
 low 37 (71) 30 (51)    
XPF high 13 (23) 31 (50) 3.31 (1.49-7.33) 5.29 (2.01-13.9) 11.5 (2.32-56.6) 
 low 43 (77) 31 (50)    
XPG high 18 (33) 30 (50) 2.06 (0.96-4.38) 1.56 (0.79-3.92) 0.48 (0.13-1.74) 
 low 37 (67) 30 (50)    
*

Dichotomized based on median values of control subjects.

Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, and lymphocyte storage time.

Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, lymphocytes.

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