American Association for Cancer Research

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Table 3.

Prevalence of HPV in HNSCCs by cancer site and geographic location

	No. studies	No. cases	Overall HPV prevalence (95% CI)	HPV16 prevalence (95% CI)
Oral cavity
Europe	15	744	16.0 (13.4-18.8)	10.8 (8.6-13.2)
North America	8	577	16.1 (13.2-19.4)	10.1 (7.7-12.8)
Asia	13	1,133	33.0 (30.3-35.8)	22.3 (20.3-25.2)
Other*	2	188	18.1 (12.9-24.3)	14.9 (10.1-20.8)
Oropharynx
Europe	17	529	28.2 (24.4-32.2)	23.8 (20.2-27.7)
North America	7	285	47.0 (41.1-53.0)	42.1 (36.3-48.1)
Asia	4	54	46.3 (32.6-60.4)	35.2 (22.7-49.4)
Other*	2	101	36.6 (27.3-46.8)	33.7 (24.6-43.8)
Larynx^†
Europe	19	799	21.3 (18.5-24.3)	13.8 (11.5-16.4)
North America	7	297	13.8 (10.1-18.3)	10.1 (7.0-14.1)
Asia	8	306	38.2 (32.8-43.9)	26.5 (21.6-31.8)
Other*	1	33	48.5 (30.8-66.5)	45.5 (28.1-63.6)

	No. studies	No. cases	Overall HPV prevalence (95% CI)	HPV16 prevalence (95% CI)
Oral cavity
Europe	15	744	16.0 (13.4-18.8)	10.8 (8.6-13.2)
North America	8	577	16.1 (13.2-19.4)	10.1 (7.7-12.8)
Asia	13	1,133	33.0 (30.3-35.8)	22.3 (20.3-25.2)
Other*	2	188	18.1 (12.9-24.3)	14.9 (10.1-20.8)
Oropharynx
Europe	17	529	28.2 (24.4-32.2)	23.8 (20.2-27.7)
North America	7	285	47.0 (41.1-53.0)	42.1 (36.3-48.1)
Asia	4	54	46.3 (32.6-60.4)	35.2 (22.7-49.4)
Other*	2	101	36.6 (27.3-46.8)	33.7 (24.6-43.8)
Larynx^†
Europe	19	799	21.3 (18.5-24.3)	13.8 (11.5-16.4)
North America	7	297	13.8 (10.1-18.3)	10.1 (7.0-14.1)
Asia	8	306	38.2 (32.8-43.9)	26.5 (21.6-31.8)
Other*	1	33	48.5 (30.8-66.5)	45.5 (28.1-63.6)

Includes Central and South America, Australia, and Africa.

Larynx includes cases of the hypopharynx.