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Table 3.

Association of premenopausal and postmenopausal weight change with breast cancer

Risk factor modelInitial intervalSubsequent intervalInitial weight change*Subsequent weight change*No. casesPerson-yearsIncidenceRR (95% CI)RR (95% CI)§
Age 30 y to menopause Menopause to baseline Gain Gain 710 132,929 530 1.00 (Reference) 1.00 (Reference) 
    No change 494 102,131 488 0.93 (0.83-1.04) 0.93 (0.82-1.04) 
    Loss 148 36,683 404 0.77 (0.64-0.92) 0.78 (0.65-0.94) 
   No change/loss Gain 325 73,973 437 0.83 (0.72-0.94) 0.82 (0.72-0.94) 
    No change 266 79,989 334 0.63 (0.55-0.73) 0.62 (0.54-0.72) 
    Loss 44 17,187 251 0.48 (0.35-0.65) 0.46 (0.34-0.64) 
Age 18-30 y Age 30 y to menopause Gain Gain 879 171,216 513 1.00 (Reference) 1.00 (Reference) 
    No change 272 67,562 400 0.78 (0.68-0.89) 0.76 (0.66-0.88) 
    Loss 55 17,737 310 0.61 (0.46-0.80) 0.62 (0.47-0.82) 
   No change/loss Gain 471 99,828 473 0.93 (0.83-1.03) 0.91 (0.81-1.03) 
    No change 289 76,825 376 0.73 (0.64-0.84) 0.71 (0.61-0.82) 
    Loss 15 8,581 176 0.36 (0.22-0.60) 0.35 (0.21-0.59) 
Risk factor modelInitial intervalSubsequent intervalInitial weight change*Subsequent weight change*No. casesPerson-yearsIncidenceRR (95% CI)RR (95% CI)§
Age 30 y to menopause Menopause to baseline Gain Gain 710 132,929 530 1.00 (Reference) 1.00 (Reference) 
    No change 494 102,131 488 0.93 (0.83-1.04) 0.93 (0.82-1.04) 
    Loss 148 36,683 404 0.77 (0.64-0.92) 0.78 (0.65-0.94) 
   No change/loss Gain 325 73,973 437 0.83 (0.72-0.94) 0.82 (0.72-0.94) 
    No change 266 79,989 334 0.63 (0.55-0.73) 0.62 (0.54-0.72) 
    Loss 44 17,187 251 0.48 (0.35-0.65) 0.46 (0.34-0.64) 
Age 18-30 y Age 30 y to menopause Gain Gain 879 171,216 513 1.00 (Reference) 1.00 (Reference) 
    No change 272 67,562 400 0.78 (0.68-0.89) 0.76 (0.66-0.88) 
    Loss 55 17,737 310 0.61 (0.46-0.80) 0.62 (0.47-0.82) 
   No change/loss Gain 471 99,828 473 0.93 (0.83-1.03) 0.91 (0.81-1.03) 
    No change 289 76,825 376 0.73 (0.64-0.84) 0.71 (0.61-0.82) 
    Loss 15 8,581 176 0.36 (0.22-0.60) 0.35 (0.21-0.59) 
*

Weight gain (loss) defined as increase (decrease) of at least 5% of body weight from beginning to end of interval.

Age-adjusted incidence per 100,000 person-years.

Accounting for age at baseline.

§

Accounting for age at baseline, BMI at age 18 years, age at menopause, education, age at menarche, oral contraceptive use, HRT, number of live births, age at first live birth, smoking status, and alcohol consumption.

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