American Association for Cancer Research

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Table 1.

Per3 genotypes and breast cancer risk stratified by menopausal status

Genotypes*	Cases, N (%)	Controls, N (%)	OR^† (95% CI)
Overall
−/−	180 (46.2)	206 (47.7)	1.0
+/−	173 (44.5)	198 (45.8)	1.1 (0.8-1.4)
+/+	36 (9.3)	28 ( 6.5)	1.5 (0.9-2.5)
+/− and +/+	209 (53.8)	226 (52.3)	1.1 (0.8-1.5)
Premenopausal Women
−/−	33 (37.5)	76 (51.0)	1.0
+/−	47 (53.4)	64 (43.0)	1.7 (1.0-3.0)
+/+	8 (9.1)	9 ( 6.0)	1.8 (0.6-5.3)
+/− and +/+	55 (62.5)	73 (49.0)	1.7 (1.0-3.0)
Postmenopausal Women
−/−	147 (48.8)	130 (45.9)	1.0
+/−	126 (41.9)	134 (47.4)	0.9 (0.6-1.2)
+/+	28 (9.3)	19 (6.7)	1.4 (0.7-2.6)
+/− and +/+	154 (51.2)	153 (54.1)	0.9 (0.7-1.3)

Genotypes*	Cases, N (%)	Controls, N (%)	OR^† (95% CI)
Overall
−/−	180 (46.2)	206 (47.7)	1.0
+/−	173 (44.5)	198 (45.8)	1.1 (0.8-1.4)
+/+	36 (9.3)	28 ( 6.5)	1.5 (0.9-2.5)
+/− and +/+	209 (53.8)	226 (52.3)	1.1 (0.8-1.5)
Premenopausal Women
−/−	33 (37.5)	76 (51.0)	1.0
+/−	47 (53.4)	64 (43.0)	1.7 (1.0-3.0)
+/+	8 (9.1)	9 ( 6.0)	1.8 (0.6-5.3)
+/− and +/+	55 (62.5)	73 (49.0)	1.7 (1.0-3.0)
Postmenopausal Women
−/−	147 (48.8)	130 (45.9)	1.0
+/−	126 (41.9)	134 (47.4)	0.9 (0.6-1.2)
+/+	28 (9.3)	19 (6.7)	1.4 (0.7-2.6)
+/− and +/+	154 (51.2)	153 (54.1)	0.9 (0.7-1.3)

−/− Homozygous 4-repeat allele; +/− heterozygous alleles; +/+ homozygous 5-repeat allele.

Adjusted for age, family history of breast cancer, family income, body mass, age at menarche, age at first birth, and county.