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Table 1.

Risk factors for MBC

KnownSuggestiveInconclusive
BRCA2 Cowden syndrome AR gene 
Family history Cirrhosis CHECK2 
Klinefelter syndrome  Prostate cancer 
Obesity  Prostate cancer treatment 
Testicular disorders  Gynecomastia 
    Cryptorchidism  Occupational exposures 
    Mumps orchitis  EMFs 
    Orchiectomy  PAHs 
Radiation exposure  High temperatures 
Exogenous estrogen  Diet 
  Alcohol 
KnownSuggestiveInconclusive
BRCA2 Cowden syndrome AR gene 
Family history Cirrhosis CHECK2 
Klinefelter syndrome  Prostate cancer 
Obesity  Prostate cancer treatment 
Testicular disorders  Gynecomastia 
    Cryptorchidism  Occupational exposures 
    Mumps orchitis  EMFs 
    Orchiectomy  PAHs 
Radiation exposure  High temperatures 
Exogenous estrogen  Diet 
  Alcohol 
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