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Table 4.

Distribution of MBD1 haplotypes, predicted by Bayesian algorithm, in controls and cases

Haplotype*Controls (n = 854)n (%)All cases (n = 849)
Histologic type of lung cancer
Squamous cell carcinoma (n = 414)
Adenocarcinoma (n = 275)
Small cell carcinoma (n = 145)
n (%)OR§ (95% CI)n (%)OR§ (95% CI)n (%)OR§ (95% CI)n (%)OR§ (95% CI)
222 631 (73.9) 597 (70.3) 1.0 297 (71.7) 1.0 188 (68.4) 1.0 101 (69.7) 1.0 
111 104 (12.2) 137 (16.1) 1.44 (1.08-1.91) 60 (14.5) 1.25 (0.87-1.79) 53 (19.3) 1.75 (1.20-2.56) 22 (15.2) 1.36 (0.81-2.28) 
212 70 (8.2) 68 (8.0) 1.00 (0.70-1.43) 35 (8.5) 1.04 (0.67-1.62) 18 (6.5) 0.82 (0.47-1.44) 14 (9.7) 1.18 (0.63-2.20) 
211 25 (2.9) 26 (3.1) 1.03 (0.58-1.83) 13 (3.1) 1.03 (0.50-2.13) 9 (3.3) 1.19 (0.54-2.66) 3 (2.1) 0.74 (0.21-2.60) 
112 24 (2.8) 21 (2.5) 0.98 (0.54-1.81) 9 (2.2) 0.83 (0.37-1.86) 7 (2.5) 1.03 (0.43-2.50) 5 (3.4) 1.43 (0.53-3.89) 
Haplotype*Controls (n = 854)n (%)All cases (n = 849)
Histologic type of lung cancer
Squamous cell carcinoma (n = 414)
Adenocarcinoma (n = 275)
Small cell carcinoma (n = 145)
n (%)OR§ (95% CI)n (%)OR§ (95% CI)n (%)OR§ (95% CI)n (%)OR§ (95% CI)
222 631 (73.9) 597 (70.3) 1.0 297 (71.7) 1.0 188 (68.4) 1.0 101 (69.7) 1.0 
111 104 (12.2) 137 (16.1) 1.44 (1.08-1.91) 60 (14.5) 1.25 (0.87-1.79) 53 (19.3) 1.75 (1.20-2.56) 22 (15.2) 1.36 (0.81-2.28) 
212 70 (8.2) 68 (8.0) 1.00 (0.70-1.43) 35 (8.5) 1.04 (0.67-1.62) 18 (6.5) 0.82 (0.47-1.44) 14 (9.7) 1.18 (0.63-2.20) 
211 25 (2.9) 26 (3.1) 1.03 (0.58-1.83) 13 (3.1) 1.03 (0.50-2.13) 9 (3.3) 1.19 (0.54-2.66) 3 (2.1) 0.74 (0.21-2.60) 
112 24 (2.8) 21 (2.5) 0.98 (0.54-1.81) 9 (2.2) 0.83 (0.37-1.86) 7 (2.5) 1.03 (0.43-2.50) 5 (3.4) 1.43 (0.53-3.89) 
*

The order of polymorphisms for the haplotypes is as follows: −634G>A, −501delT, and Pro401Ala. The wild-type allele (−634G, −501T, and 401Pro) is denoted by 1 and the polymorphic allele is denoted by 2.

Three haplotypes that had a frequency of <1 % were excluded from analysis; controls 10 and cases 15 (squamous cell carcinoma, n = 6; adenocarcinoma, n = 7; large cell carcinoma, n = 1; and small cell carcinoma, n = 1), respectively.

Eight large cell carcinoma cases were excluded from analysis.

§

Adjusted for age, sex, pack-years of smoking, and family history of lung cancer.

P = 0.012 and Pc = 0.048 (Bonferroni corrected P).

P = 0.004 and Pc = 0.016.

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