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Table 2.

Genotype frequencies of MBD1 polymorphisms in lung cancer cases and controls

PolymorphismVariablesGenotype*
Polymorphic allele frequency
1/11/22/2
−634G>A Controls (1.6) 118 (27.3) 307 (71.1) 0.847 
 All cases 17 (3.9) 134 (31.0) 281 (65.0) 0.806 
 Squamous cell carcinoma 6 (2.9) 62 (29.5) 142 (67.6) 0.824 
 Adenocarcinoma 9 (6.4) 46 (32.6) 86 (61.0)§ 0.773 
 Large cell carcinoma 0 (0.0) 3 (37.5) 5 (62.5) 0.812 
 Small cell carcinoma 2 (2.7) 22 (30.1) 49 (67.1) 0.822 
−501delT Controls 26 (6.0) 171 (39.6) 235 (54.4) 0.742 
 All cases 33 (7.6) 186 (43.1) 213 (49.3) 0.708 
 Squamous cell carcinoma 11 (5.2) 95 (45.2) 104 (49.5) 0.721 
 Adenocarcinoma 16 (11.3) 55 (39.0) 70 (49.7) 0.691 
 Large cell carcinoma 0 (0.0) 4 (50.0) 4 (50.0) 0.750 
 Small cell carcinoma 6 (8.2) 32 (43.8) 35 (48.0) 0.699 
Pro401Ala (C→G) Controls 9 (2.1) 120 (27.8) 303 (70.1) 0.840 
 All cases 15 (3.5) 138 (31.9) 279 (64.6) 0.806 
 Squamous cell carcinoma 5 (2.4) 64 (30.5) 141 (67.1) 0.824 
 Adenocarcinoma 8 (5.7) 49 (34.7) 84 (59.6) 0.770 
 Large cell carcinoma 0 (0.0) 3 (37.5) 5 (62.5) 0.812 
 Small cell carcinoma 2 (2.7) 22 (30.1) 49 (67.1) 0.822 
PolymorphismVariablesGenotype*
Polymorphic allele frequency
1/11/22/2
−634G>A Controls (1.6) 118 (27.3) 307 (71.1) 0.847 
 All cases 17 (3.9) 134 (31.0) 281 (65.0) 0.806 
 Squamous cell carcinoma 6 (2.9) 62 (29.5) 142 (67.6) 0.824 
 Adenocarcinoma 9 (6.4) 46 (32.6) 86 (61.0)§ 0.773 
 Large cell carcinoma 0 (0.0) 3 (37.5) 5 (62.5) 0.812 
 Small cell carcinoma 2 (2.7) 22 (30.1) 49 (67.1) 0.822 
−501delT Controls 26 (6.0) 171 (39.6) 235 (54.4) 0.742 
 All cases 33 (7.6) 186 (43.1) 213 (49.3) 0.708 
 Squamous cell carcinoma 11 (5.2) 95 (45.2) 104 (49.5) 0.721 
 Adenocarcinoma 16 (11.3) 55 (39.0) 70 (49.7) 0.691 
 Large cell carcinoma 0 (0.0) 4 (50.0) 4 (50.0) 0.750 
 Small cell carcinoma 6 (8.2) 32 (43.8) 35 (48.0) 0.699 
Pro401Ala (C→G) Controls 9 (2.1) 120 (27.8) 303 (70.1) 0.840 
 All cases 15 (3.5) 138 (31.9) 279 (64.6) 0.806 
 Squamous cell carcinoma 5 (2.4) 64 (30.5) 141 (67.1) 0.824 
 Adenocarcinoma 8 (5.7) 49 (34.7) 84 (59.6) 0.770 
 Large cell carcinoma 0 (0.0) 3 (37.5) 5 (62.5) 0.812 
 Small cell carcinoma 2 (2.7) 22 (30.1) 49 (67.1) 0.822 
*

The wild-type allele (−634G, −501T, and 401Pro) is denoted by 1 and the polymorphic allele is denoted by 2.

Row percentage in brackets.

Difference from controls (P = 0.04).

§

Difference from controls (P = 0.001).

Difference from controls (P = 0.02).

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