American Association for Cancer Research

Table 3.

Adjusted ORs and 95% CIs for associations between IGF1 (CA)₁₉ repeat and IGFBP3 −202 A/C genotypes in DVAMC prostate cancer cases and controls

	Overall*			Blacks*			Whites*
		No. cases/no. controls	OR^† (95% CI)	No. cases/no. controls	OR^† (95% CI)	No. cases/no. controls	OR^† (95% CI)
IGF1 (CA)₁₉ genotypes^‡
(CA)₁₉/(CA)₁₉	20/28	0.3 (0.1-0.7)	3/9	0.2 (0.0-0.8)	17/19	0.4 (0.1-1.6)
(CA)₁₉/x	39/33	0.6 (0.3-1.4)	19/17	0.7 (0.3-1.7)	20/16	0.7 (0.2-2.4)
x/x	35/20	1.0 (reference)	25/15	1.0 (reference)	10/5	1.0 (reference)
IGFBP3 -202 A/C genotypes
CC	26/26	1.3 (0.6-3.1)	11/11	1.5 (0.4-5.1)	15/15	1.0 (0.3-3.5)
AC	53/39	1.9 (0.9-4.1)	29/20	2.9 (1.0-8.6)	24/19	1.0 (0.3-3.3)
AA	18/23	1.0 (reference)	9/15	1.0 (reference)	9/8	1.0 (reference)
IGFBP3 -202 A/C genotypes
CC/AC	79/65	1.7 (0.8-3.4)	40/31	2.3 (0.8-6.2)	39/34	1.0 (0.3-3.1)
AA	18/23	1.0 (reference)	9/15	1.0 (reference)	9/8	1.0 (reference)

	Overall*			Blacks*			Whites*
		No. cases/no. controls	OR^† (95% CI)	No. cases/no. controls	OR^† (95% CI)	No. cases/no. controls	OR^† (95% CI)
IGF1 (CA)₁₉ genotypes^‡
(CA)₁₉/(CA)₁₉	20/28	0.3 (0.1-0.7)	3/9	0.2 (0.0-0.8)	17/19	0.4 (0.1-1.6)
(CA)₁₉/x	39/33	0.6 (0.3-1.4)	19/17	0.7 (0.3-1.7)	20/16	0.7 (0.2-2.4)
x/x	35/20	1.0 (reference)	25/15	1.0 (reference)	10/5	1.0 (reference)
IGFBP3 -202 A/C genotypes
CC	26/26	1.3 (0.6-3.1)	11/11	1.5 (0.4-5.1)	15/15	1.0 (0.3-3.5)
AC	53/39	1.9 (0.9-4.1)	29/20	2.9 (1.0-8.6)	24/19	1.0 (0.3-3.3)
AA	18/23	1.0 (reference)	9/15	1.0 (reference)	9/8	1.0 (reference)
IGFBP3 -202 A/C genotypes
CC/AC	79/65	1.7 (0.8-3.4)	40/31	2.3 (0.8-6.2)	39/34	1.0 (0.3-3.1)
AA	18/23	1.0 (reference)	9/15	1.0 (reference)	9/8	1.0 (reference)

Frequencies exclude subjects with missing values for any of the adjustment variables.

†

OR adjusted for age, body mass index, height, and diabetes (also race in the overall analyses).

‡

x, non-(CA)₁₉ allele.

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