Results of the base model (bold) and one-way sensitivity analyses for the offer of annual stool testing in combination with colonoscopic follow-up of positive test results (scheme A) exemplified by performance characteristics of Hemoccult II: proportion P (%) of early detected or prevented CRC cases, number of stool tests (No. tests), and number of colonoscopies (No. col.) per early detected or prevented CRC case
| Variable . | Values . | Model outcomes . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | P (%) . | No. tests . | No. col. . | ||
| Compliance rate with stool testing* | 60% | 22.6 | 1,022 | 22 | ||
| 50% | 19.2 | 1,020 | 22 | |||
| 40% | 15.6 | 1,019 | 22 | |||
| 30% | 12.0 | 1,018 | 22 | |||
| 20% | 8.1 | 1,017 | 22 | |||
| Compliance rate with follow-up colonoscopy | 100% | 17.2 | 918 | 22 | ||
| 90% | 15.6 | 1,019 | 22 | |||
| 80% | 14.0 | 1,146 | 22 | |||
| Target age range for screening | 55-74 | 15.6 | 1,019 | 22 | ||
| 60-74 | 14.4 | 968 | 21 | |||
| Annual decrease of risk reduction after colonoscopy | 1% | 16.2 | 986 | 21 | ||
| 2% | 15.6 | 1,019 | 22 | |||
| 3% | 15.1 | 1,055 | 22 | |||
| Variable . | Values . | Model outcomes . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | P (%) . | No. tests . | No. col. . | ||
| Compliance rate with stool testing* | 60% | 22.6 | 1,022 | 22 | ||
| 50% | 19.2 | 1,020 | 22 | |||
| 40% | 15.6 | 1,019 | 22 | |||
| 30% | 12.0 | 1,018 | 22 | |||
| 20% | 8.1 | 1,017 | 22 | |||
| Compliance rate with follow-up colonoscopy | 100% | 17.2 | 918 | 22 | ||
| 90% | 15.6 | 1,019 | 22 | |||
| 80% | 14.0 | 1,146 | 22 | |||
| Target age range for screening | 55-74 | 15.6 | 1,019 | 22 | ||
| 60-74 | 14.4 | 968 | 21 | |||
| Annual decrease of risk reduction after colonoscopy | 1% | 16.2 | 986 | 21 | ||
| 2% | 15.6 | 1,019 | 22 | |||
| 3% | 15.1 | 1,055 | 22 | |||
Compliance among subjects who are in principle willing to participate in screening (= 80% of subjects of the original cohort).