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Table 4.

Results of the base model (bold) and one-way sensitivity analyses for the offer of annual stool testing in combination with colonoscopic follow-up of positive test results (scheme A) exemplified by performance characteristics of Hemoccult II: proportion P (%) of early detected or prevented CRC cases, number of stool tests (No. tests), and number of colonoscopies (No. col.) per early detected or prevented CRC case

VariableValuesModel outcomes
P (%)No. testsNo. col.
Compliance rate with stool testing* 60% 22.6 1,022 22 
 50% 19.2 1,020 22 
 40% 15.6 1,019 22 
 30% 12.0 1,018 22 
 20%
 
8.1
 
1,017
 
22
 
Compliance rate with follow-up colonoscopy 100% 17.2 918 22 
 90% 15.6 1,019 22 
 80%
 
14.0
 
1,146
 
22
 
Target age range for screening 55-74 15.6 1,019 22 
 60-74
 
14.4
 
968
 
21
 
Annual decrease of risk reduction after colonoscopy 1% 16.2 986 21 
 2% 15.6 1,019 22 
 3% 15.1 1,055 22 
VariableValuesModel outcomes
P (%)No. testsNo. col.
Compliance rate with stool testing* 60% 22.6 1,022 22 
 50% 19.2 1,020 22 
 40% 15.6 1,019 22 
 30% 12.0 1,018 22 
 20%
 
8.1
 
1,017
 
22
 
Compliance rate with follow-up colonoscopy 100% 17.2 918 22 
 90% 15.6 1,019 22 
 80%
 
14.0
 
1,146
 
22
 
Target age range for screening 55-74 15.6 1,019 22 
 60-74
 
14.4
 
968
 
21
 
Annual decrease of risk reduction after colonoscopy 1% 16.2 986 21 
 2% 15.6 1,019 22 
 3% 15.1 1,055 22 
*

Compliance among subjects who are in principle willing to participate in screening (= 80% of subjects of the original cohort).

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