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Table 2.

Comparison of mean B(a)P-DNA adducts by treatment group, gender, and GSTM1

Unadjusted geometric mean B(a)P-DNA adducts
Adjusted by pretreatment B(a)P-DNA adducts and pretreatment cotinine
TreatmentPlaceboTreatment/placebo95% Confidence intervalPTreatmentPlaceboTreatment/placebo95% Confidence intervalP
All subjects with 15 months follow-up 0.39 (n = 83) 0.45 (n = 93) 0.86 0.69-1.08 0.20 0.39 0.45 0.86 0.69-1.08 0.19 
Women 0.32 (n = 37) 0.46 (n = 43) 0.70 0.51-0.97 0.04* 0.32 0.46 0.69 0.50-0.95 0.03 
Men 0.46 (n = 46) 0.45 (n = 50) 1.02 0.75-1.38 0.92 0.46 0.46 1.00 0.74-1.36 0.98 
GSTM normal 0.43 (n = 52) 0.50 (n = 62) 0.86 0.64-1.15 0.30 0.43 0.49 0.87 0.65-1.17 0.36 
GSTM null 0.34 (n = 31) 0.38 (n = 31) 0.90 0.65-1.25 0.54 0.35 0.37 0.94 0.66-1.32 0.71 
Women: GSTM normal 0.35 (n = 28) 0.47 (n = 29) 0.74 0.49-1.12 0.16 0.34 0.47 0.73 0.48-1.10 0.14 
Women: GSTM null 0.25 (n = 9) 0.43 (n = 14) 0.58 0.37-0.93 0.04* 0.25 0.44 0.57 0.35-0.94 0.04* 
Men: GSTM normal 0.54 (n = 24) 0.53 (n = 33) 1.03 0.69-1.55 0.88 0.56 0.52 1.07 0.72-1.61 0.73 
Men: GSTM null 0.38 (n = 22) 0.34 (n = 17) 1.14 0.73-1.78 0.57 0.40 0.32 1.23 0.76-2.00 0.40 
Unadjusted geometric mean B(a)P-DNA adducts
Adjusted by pretreatment B(a)P-DNA adducts and pretreatment cotinine
TreatmentPlaceboTreatment/placebo95% Confidence intervalPTreatmentPlaceboTreatment/placebo95% Confidence intervalP
All subjects with 15 months follow-up 0.39 (n = 83) 0.45 (n = 93) 0.86 0.69-1.08 0.20 0.39 0.45 0.86 0.69-1.08 0.19 
Women 0.32 (n = 37) 0.46 (n = 43) 0.70 0.51-0.97 0.04* 0.32 0.46 0.69 0.50-0.95 0.03 
Men 0.46 (n = 46) 0.45 (n = 50) 1.02 0.75-1.38 0.92 0.46 0.46 1.00 0.74-1.36 0.98 
GSTM normal 0.43 (n = 52) 0.50 (n = 62) 0.86 0.64-1.15 0.30 0.43 0.49 0.87 0.65-1.17 0.36 
GSTM null 0.34 (n = 31) 0.38 (n = 31) 0.90 0.65-1.25 0.54 0.35 0.37 0.94 0.66-1.32 0.71 
Women: GSTM normal 0.35 (n = 28) 0.47 (n = 29) 0.74 0.49-1.12 0.16 0.34 0.47 0.73 0.48-1.10 0.14 
Women: GSTM null 0.25 (n = 9) 0.43 (n = 14) 0.58 0.37-0.93 0.04* 0.25 0.44 0.57 0.35-0.94 0.04* 
Men: GSTM normal 0.54 (n = 24) 0.53 (n = 33) 1.03 0.69-1.55 0.88 0.56 0.52 1.07 0.72-1.61 0.73 
Men: GSTM null 0.38 (n = 22) 0.34 (n = 17) 1.14 0.73-1.78 0.57 0.40 0.32 1.23 0.76-2.00 0.40 
*

P < 0.05.

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