American Association for Cancer Research

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Table 3.

Association between incident cancer events and inflammatory markers

Inflammatory markers	HR* (95% CI) Number of events
		All cancer events					Nonfatal cancer events	Cancer death
		Unadjusted	Adjusted^†	NSAIDs users excluded^†	Adjusted^†	Adjusted^†	NSAIDs users excluded^†
log(IL-6), pg/mL	1.18 (0.98-1.41) 273	1.13 (0.94-1.37) 273	1.10 (0.90-1.35) 229	0.95 (0.75-1.19) 189	1.63 (1.19-2.23) 84	1.65 (1.19-2.29) 80
log(CRP), mg/L	1.17 (1.02-1.33) 291	1.25 (1.09-1.43) 291	1.23 (1.06-1.43) 243	1.17 (1.00-1.38) 201	1.41 (1.13-1.77) 90	1.51 (1.19-1.92) 85
log(TNF-α), pg/mL	1.32 (1.00-1.76) 275	1.28 (0.96-1.70) 275	1.39 (1.02-1.90) 229	1.07 (0.76-1.52) 188	1.82 (1.14-2.92) 87	1.95 (1.20-3.15) 82

Inflammatory markers	HR* (95% CI) Number of events
		All cancer events					Nonfatal cancer events	Cancer death
		Unadjusted	Adjusted^†	NSAIDs users excluded^†	Adjusted^†	Adjusted^†	NSAIDs users excluded^†
log(IL-6), pg/mL	1.18 (0.98-1.41) 273	1.13 (0.94-1.37) 273	1.10 (0.90-1.35) 229	0.95 (0.75-1.19) 189	1.63 (1.19-2.23) 84	1.65 (1.19-2.29) 80
log(CRP), mg/L	1.17 (1.02-1.33) 291	1.25 (1.09-1.43) 291	1.23 (1.06-1.43) 243	1.17 (1.00-1.38) 201	1.41 (1.13-1.77) 90	1.51 (1.19-1.92) 85
log(TNF-α), pg/mL	1.32 (1.00-1.76) 275	1.28 (0.96-1.70) 275	1.39 (1.02-1.90) 229	1.07 (0.76-1.52) 188	1.82 (1.14-2.92) 87	1.95 (1.20-3.15) 82

Log-transformed variables: the HR present the associations with the inflammatory markers related to a unit change on the log scale.

HR adjusted for age, gender, race, and site.