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Table 3.

Association between incident cancer events and inflammatory markers

Inflammatory markersHR* (95% CI) Number of events
All cancer events
Nonfatal cancer events
Cancer death
UnadjustedAdjustedNSAIDs users excludedAdjustedAdjustedNSAIDs users excluded
log(IL-6), pg/mL 1.18 (0.98-1.41) 273 1.13 (0.94-1.37) 273 1.10 (0.90-1.35) 229 0.95 (0.75-1.19) 189 1.63 (1.19-2.23) 84 1.65 (1.19-2.29) 80 
log(CRP), mg/L 1.17 (1.02-1.33) 291 1.25 (1.09-1.43) 291 1.23 (1.06-1.43) 243 1.17 (1.00-1.38) 201 1.41 (1.13-1.77) 90 1.51 (1.19-1.92) 85 
log(TNF-α), pg/mL 1.32 (1.00-1.76) 275 1.28 (0.96-1.70) 275 1.39 (1.02-1.90) 229 1.07 (0.76-1.52) 188 1.82 (1.14-2.92) 87 1.95 (1.20-3.15) 82 
Inflammatory markersHR* (95% CI) Number of events
All cancer events
Nonfatal cancer events
Cancer death
UnadjustedAdjustedNSAIDs users excludedAdjustedAdjustedNSAIDs users excluded
log(IL-6), pg/mL 1.18 (0.98-1.41) 273 1.13 (0.94-1.37) 273 1.10 (0.90-1.35) 229 0.95 (0.75-1.19) 189 1.63 (1.19-2.23) 84 1.65 (1.19-2.29) 80 
log(CRP), mg/L 1.17 (1.02-1.33) 291 1.25 (1.09-1.43) 291 1.23 (1.06-1.43) 243 1.17 (1.00-1.38) 201 1.41 (1.13-1.77) 90 1.51 (1.19-1.92) 85 
log(TNF-α), pg/mL 1.32 (1.00-1.76) 275 1.28 (0.96-1.70) 275 1.39 (1.02-1.90) 229 1.07 (0.76-1.52) 188 1.82 (1.14-2.92) 87 1.95 (1.20-3.15) 82 
*

Log-transformed variables: the HR present the associations with the inflammatory markers related to a unit change on the log scale.

HR adjusted for age, gender, race, and site.

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