Associations of hormone-related conditions with breast cancer by CCND1 genotype, the Shanghai Women's Breast Cancer Study*
| . | Quartile levels . | . | . | . | . | . | . | . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Q1 . | . | Q2 . | . | Q3 . | . | Q4 . | . | P for trend . | |||||||||
| . | Case/control . | OR (reference) . | Case/control . | OR (95% CI) . | Case/control . | OR(95% CI) . | Case/control . | OR (95% CI) . | . | |||||||||
| All subjects | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 42/61 | 1.0 | 62/63 | 1.4 (0.8-2.3) | 59/59 | 1.3 (0.8-2.3) | 50/67 | 1.0 (0.6-1.8) | 0.20 | |||||||||
| GA/AA | 195/237 | 1.0 | 207/236 | 1.0 (0.8-1.3) | 236/240 | 1.2 (0.9-1.5) | 277/232 | 1.4 (1.1-1.9) | 0.002 | |||||||||
| P for interaction = 0.26 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 51/58 | 1.0 | 53/55 | 1.1 (0.6-1.9) | 51/57 | 1.0 (0.6-1.7) | 58/80 | 0.8 (0.5-1.3) | 0.08 | |||||||||
| GA/AA | 173/242 | 1.0 | 220/252 | 1.2(0.9-1.6) | 247/234 | 1.5(1.1-1.9) | 275/217 | 1.8(1.4-2.4) | <0.001 | |||||||||
| P for interaction = 0.03 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 25/61 | 1.0 | 57/67 | 2.2 (1.1-4.3) | 51/48 | 3.0 (1.4-6.5) | 80/74 | 3.3 (1.5-7.2) | 0.002 | |||||||||
| GA/AA | 135/217 | 1.0 | 211/233 | 1.5 (1.0-2.1) | 228/207 | 2.1 (1.4-3.2) | 337/284 | 2.7 (1.8-4.1) | <0.001 | |||||||||
| P for interaction = 0.62 | ||||||||||||||||||
| Premenopausal women | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 27/39 | 1.0 | 30/40 | 1.0 (0.5-2.0) | 45/42 | 1.4 (0.7-2.7) | 35/36 | 1.2 (0.6-2.5) | 0.93 | |||||||||
| GA/AA | 134/151 | 1.0 | 135/148 | 1.0 (0.7-1.4) | 164/150 | 1.1 (0.8-1.6) | 185/155 | 1.2 (0.9-1.7) | 0.12 | |||||||||
| P for interaction = 0.91 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 32/35 | 1.0 | 30/41 | 0.8 (0.4-1.5) | 37/38 | 1.1 (0.6-2.1) | 38/43 | 0.9 (0.4-1.7) | 0.61 | |||||||||
| GA/AA | 108/161 | 1.0 | 149/141 | 1.6 (1.1-2.2) | 169/154 | 1.6 (1.1-2.2) | 192/148 | 1.9 (1.3-2.6) | <0.001 | |||||||||
| P for interaction = 0.20 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 16/31 | 1.0 | 26/41 | 1.2 (0.5-3.1) | 41/42 | 2.1 (0.7-6.7) | 54/43 | 3.2 (0.8-12.0) | 0.10 | |||||||||
| GA/AA | 86/139 | 1.0 | 97/123 | 1.4(0.9-2.2) | 199/162 | 2.7 (1.6-4.6) | 237/180 | 3.9 (2.1-7.3) | <0.001 | |||||||||
| P for interaction = 0.92 | ||||||||||||||||||
| Postmenopausal women | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 23/16 | 1.0 | 21/28 | 0.5 (0.2-1.2) | 10/18 | 0.3 (0.1-1.0) | 22/31 | 0.5 (0.2-1.2) | 0.10 | |||||||||
| GA/AA | 56/92 | 1.0 | 67/79 | 1.4 (0.9-2.2) | 74/89 | 1.4 (0.9-2.2) | 95/77 | 2.1 (1.3-3.2) | 0.002 | |||||||||
| P for interaction = 0.02 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 18/18 | 1.0 | 23/20 | 1.0 (0.4-2.6) | 16/22 | 0.6 (0.2-1.6) | 19/33 | 0.5 (0.2-1.3) | 0.023 | |||||||||
| GA/AA | 61/95 | 1.0 | 63/81 | 1.2 (0.8-2.0) | 74/88 | 1.3 (0.9-2.1) | 94/73 | 2.1 (1.3-3.3) | 0.006 | |||||||||
| P for interaction = 0.03 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 10/23 | 1.0 | 27/27 | 2.5 (1.0-6.7) | 14/19 | 2.2 (0.8-6.7) | 25/24 | 3.2 (1.2-8.8) | 0.01 | |||||||||
| GA/AA | 34/76 | 1.0 | 75/79 | 2.2(1.3-3.8) | 75/81 | 2.2(1.3-3.8) | 108/101 | 2.7(1.6-4.5) | <0.001 | |||||||||
| P for interaction = 0.97 | ||||||||||||||||||
| . | Quartile levels . | . | . | . | . | . | . | . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Q1 . | . | Q2 . | . | Q3 . | . | Q4 . | . | P for trend . | |||||||||
| . | Case/control . | OR (reference) . | Case/control . | OR (95% CI) . | Case/control . | OR(95% CI) . | Case/control . | OR (95% CI) . | . | |||||||||
| All subjects | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 42/61 | 1.0 | 62/63 | 1.4 (0.8-2.3) | 59/59 | 1.3 (0.8-2.3) | 50/67 | 1.0 (0.6-1.8) | 0.20 | |||||||||
| GA/AA | 195/237 | 1.0 | 207/236 | 1.0 (0.8-1.3) | 236/240 | 1.2 (0.9-1.5) | 277/232 | 1.4 (1.1-1.9) | 0.002 | |||||||||
| P for interaction = 0.26 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 51/58 | 1.0 | 53/55 | 1.1 (0.6-1.9) | 51/57 | 1.0 (0.6-1.7) | 58/80 | 0.8 (0.5-1.3) | 0.08 | |||||||||
| GA/AA | 173/242 | 1.0 | 220/252 | 1.2(0.9-1.6) | 247/234 | 1.5(1.1-1.9) | 275/217 | 1.8(1.4-2.4) | <0.001 | |||||||||
| P for interaction = 0.03 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 25/61 | 1.0 | 57/67 | 2.2 (1.1-4.3) | 51/48 | 3.0 (1.4-6.5) | 80/74 | 3.3 (1.5-7.2) | 0.002 | |||||||||
| GA/AA | 135/217 | 1.0 | 211/233 | 1.5 (1.0-2.1) | 228/207 | 2.1 (1.4-3.2) | 337/284 | 2.7 (1.8-4.1) | <0.001 | |||||||||
| P for interaction = 0.62 | ||||||||||||||||||
| Premenopausal women | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 27/39 | 1.0 | 30/40 | 1.0 (0.5-2.0) | 45/42 | 1.4 (0.7-2.7) | 35/36 | 1.2 (0.6-2.5) | 0.93 | |||||||||
| GA/AA | 134/151 | 1.0 | 135/148 | 1.0 (0.7-1.4) | 164/150 | 1.1 (0.8-1.6) | 185/155 | 1.2 (0.9-1.7) | 0.12 | |||||||||
| P for interaction = 0.91 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 32/35 | 1.0 | 30/41 | 0.8 (0.4-1.5) | 37/38 | 1.1 (0.6-2.1) | 38/43 | 0.9 (0.4-1.7) | 0.61 | |||||||||
| GA/AA | 108/161 | 1.0 | 149/141 | 1.6 (1.1-2.2) | 169/154 | 1.6 (1.1-2.2) | 192/148 | 1.9 (1.3-2.6) | <0.001 | |||||||||
| P for interaction = 0.20 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 16/31 | 1.0 | 26/41 | 1.2 (0.5-3.1) | 41/42 | 2.1 (0.7-6.7) | 54/43 | 3.2 (0.8-12.0) | 0.10 | |||||||||
| GA/AA | 86/139 | 1.0 | 97/123 | 1.4(0.9-2.2) | 199/162 | 2.7 (1.6-4.6) | 237/180 | 3.9 (2.1-7.3) | <0.001 | |||||||||
| P for interaction = 0.92 | ||||||||||||||||||
| Postmenopausal women | ||||||||||||||||||
| BMI | ||||||||||||||||||
| GG | 23/16 | 1.0 | 21/28 | 0.5 (0.2-1.2) | 10/18 | 0.3 (0.1-1.0) | 22/31 | 0.5 (0.2-1.2) | 0.10 | |||||||||
| GA/AA | 56/92 | 1.0 | 67/79 | 1.4 (0.9-2.2) | 74/89 | 1.4 (0.9-2.2) | 95/77 | 2.1 (1.3-3.2) | 0.002 | |||||||||
| P for interaction = 0.02 | ||||||||||||||||||
| WHR | ||||||||||||||||||
| GG | 18/18 | 1.0 | 23/20 | 1.0 (0.4-2.6) | 16/22 | 0.6 (0.2-1.6) | 19/33 | 0.5 (0.2-1.3) | 0.023 | |||||||||
| GA/AA | 61/95 | 1.0 | 63/81 | 1.2 (0.8-2.0) | 74/88 | 1.3 (0.9-2.1) | 94/73 | 2.1 (1.3-3.3) | 0.006 | |||||||||
| P for interaction = 0.03 | ||||||||||||||||||
| Years of menstruation | ||||||||||||||||||
| GG | 10/23 | 1.0 | 27/27 | 2.5 (1.0-6.7) | 14/19 | 2.2 (0.8-6.7) | 25/24 | 3.2 (1.2-8.8) | 0.01 | |||||||||
| GA/AA | 34/76 | 1.0 | 75/79 | 2.2(1.3-3.8) | 75/81 | 2.2(1.3-3.8) | 108/101 | 2.7(1.6-4.5) | <0.001 | |||||||||
| P for interaction = 0.97 | ||||||||||||||||||
Adjusted for age.